DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lip4 and lipa

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001015847.2	Gene:	lipa / 548564	XenbaseID:	XB-GENE-952977	Length:	409	Species:	Xenopus tropicalis

Alignment Length:	397	Identity:	153/397 - (38%)
Similarity:	225/397 - (56%)	Gaps:	25/397 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PTFLGRSVAVDSNVRLENDVDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRI---- 114
            |:.:...||.|    |....||    ::.:|...||:..|||:|.:.:.|:|||||:::||
Frog    26 PSRIRHGVAGD----LLYSADP----EATMNISELIRYRGYPSEEYEVLTEDGYILSVNRIPHGV 82

  Fly   115 --ARPGATPVL-LVHGLLDSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHH 176
              |..|..||: |.||||...:.||....|..||::|.|.|||||:.|.||||:||||...|...
Frog    83 KYASEGPKPVVFLQHGLLADGSNWVTNLENNSLGFILADAGYDVWIGNSRGNTWSRKHKSLSPDQ 147

  Fly   177 AKFWDFTFHEMGKHDIPATMDYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLA 241
            .:||.|::.|:.|.|:||.:|:|...||..|:.|:||||||.:.:|..|..|:...||.:..|||
Frog   148 EEFWAFSYDELAKKDLPAVVDFITKKTGQEQIFYVGHSQGTTIAFIAFSSLPQLAKKIKMYFGLA 212

  Fly   242 PVAFLKHCRSPV--VNFLAEWHLSVSLVLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNV 304
            |||.:|..:||:  :..|.|:     |:.:|.|..||||:...|:......|.. .|..|:|.|:
Frog   213 PVATVKFSKSPLAKLGVLPEF-----LIEELFGKGEFLPQTYLITWLATHFCTH-AIADELCGNI 271

  Fly   305 IFLTTGFDKLQLNETMLPVIVGHSPAGASTKQMQHFGQLNRSGGFRQYDHGWLRNHWIYGTIDPP 369
            .||.:||::..||.:.:.|...|.|||.|.:.|.|:.|..|||..:.:|.|...|...|....||
Frog   272 FFLLSGFNEKNLNMSRVNVYSSHCPAGTSVQNMLHWRQGVRSGELKAFDFGTKGNMIHYNQTTPP 336

  Fly   370 SYHLENVRAKVALYYGQNDWLAPPEDVEMLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWD 434
            .||:.::....||:.|.|||||..:||.:|..::.|:|  |..:..::.|||||||:||.|.:::
Frog   337 FYHVRDMTVPTALWTGGNDWLADRKDVALLLTQVSNLV--YHKEIPDWEHLDFIWGLDAPERMYN 399

  Fly   435 RMLEIMR 441
            .::.:|:
Frog   400 EIIAMMK 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	145/363 (40%)
		Abhydro_lipase	88..139	CDD:282003	25/57 (44%)
		Abhydrolase_5	121..>253	CDD:289465	62/132 (47%)
		Abhydrolase_5	<368..419	CDD:289465	18/50 (36%)
lipa	NP_001015847.2	Abhydro_lipase	49..110	CDD:282003	25/60 (42%)
		PLN02872	50..409	CDD:215470	145/365 (40%)
		Abhydrolase_5	91..>229	CDD:289465	63/137 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12011
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2899
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		otm47739
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080