DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and LIPA

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_000226.2	Gene:	LIPA / 3988	HGNCID:	6617	Length:	399	Species:	Homo sapiens

Alignment Length:	381	Identity:	146/381 - (38%)
Similarity:	227/381 - (59%)	Gaps:	19/381 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRI-------ARPGATPVL-LVHGLL 129
            |||    ::::|...:|..:|:|:|.:.:||:|||||.|:||       :..|..||: |.||||
Human    29 VDP----ETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLL 89

  Fly   130 DSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPA 194
            ..|:.||....|..||::|.|.|:||||.|.||||:||||...|....:||.|::.||.|:|:||
Human    90 ADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPA 154

  Fly   195 TMDYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAE 259
            ::::|||.||..|::|:||||||.:.:|..|:.||...:|.:...|.|||.:..|.||:...
Human   155 SINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKL--- 216

  Fly   260 WHLSVSLVLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETMLPVI 324
            ..|...|:..|.|..||||::.|:......:|.. .|.||:|.|:.||..||::..||.:.:.|.
Human   217 GRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTH-VILKELCGNLCFLLCGFNERNLNMSRVDVY 280

  Fly   325 VGHSPAGASTKQMQHFGQLNRSGGFRQYDHG-WLRNHWIYGTIDPPSYHLENVRAKVALYYGQND 388
            ..|||||.|.:.|.|:.|..:...|:.:|.| ..:|::.|....||:|:::::....|::.|.:|
Human   281 TTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHD 345

  Fly   389 WLAPPEDVEMLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIMRNHE 444
            |||...||.:|..::.|:|  :.....|:.|||||||:||...|:::::.:||.::
Human   346 WLADVYDVNILLTQITNLV--FHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	142/366 (39%)
		Abhydro_lipase	88..139	CDD:282003	25/58 (43%)
		Abhydrolase_5	121..>253	CDD:289465	63/132 (48%)
		Abhydrolase_5	<368..419	CDD:289465	15/50 (30%)
LIPA	NP_000226.2	PLN02872	38..396	CDD:215470	140/363 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141854
Domainoid	1	1.000	45	1.000	Domainoid score	I12200
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840