DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and Lipo3

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001013792.2	Gene:	Lipo3 / 381236	MGIID:	2147592	Length:	399	Species:	Mus musculus

Alignment Length:	382	Identity:	137/382 - (35%)
Similarity:	220/382 - (57%)	Gaps:	16/382 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRIAR-----PGATPVLLV---HGLLDS 131
            |....::|:|...:||.:.||:|.:.:.|||||||.::||..     ..:.|.::|   ||||.:
Mouse    23 PKKNPEAHMNVSEIIKHWDYPSEEYEVVTDDGYILPINRIPHGKNNANSSAPKMVVFCQHGLLAT 87

  Fly   132 SATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPATM 196
            ...||...|...|.::|.|.||||||.:.||:|:::|||..:....:||||:|.:|.|:|:|||:
Mouse    88 PGAWVSNPPVNSLAFILADAGYDVWMGSSRGSTWAKKHVALNPDSKEFWDFSFDQMIKYDLPATI 152

  Fly   197 DYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAEWH 261
            ::||:.||..|::||||||||::.....:......:||.|...|||:..::|.:.  ::.||. :
Mouse   153 NFILDKTGQKQIYYIGHSQGTLLAIGAFATNQTLAEKIKLNILLAPIYSVQHSKG--ISHLAS-Y 214

  Fly   262 LSVSLVLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETMLPVIVG 326
            |:.:.:..|.|..||.|...| |.....:|:....| .||:.::....|:...|||::.|.|.|.
Mouse   215 LTPTTIKLLFGEKEFFPTVVF-SEVGACVCNINFFT-AICAAIMGSMGGYSPDQLNKSRLDVYVK 277

  Fly   327 HSPAGASTKQMQHFGQLNRSGGFRQYDHGW-LRNHWIYGTIDPPSYHLENVRAKVALYYGQNDWL 390
            .:.||.|.|.:.|:.|:.|||..:.||.|. ..|...|....||.|::|:::...|::.|..|:|
Mouse   278 LNLAGTSVKVLIHYNQVGRSGILQAYDWGSPSLNMQHYNQTTPPVYNVEDMKVPTAMFTGLKDFL 342

  Fly   391 APPEDVEMLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIMRNHENSI 447
            :.|||||:|..|:.|:.  ||....:|:|.|||.|::||:.:.:.:|.|:|.:|..:
Mouse   343 SDPEDVEILKPKIHNLT--YLKTIPDFSHFDFILGLNARKEVSEEILTILRKYEGDV 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	134/366 (37%)
		Abhydro_lipase	88..139	CDD:282003	22/58 (38%)
		Abhydrolase_5	121..>253	CDD:289465	55/134 (41%)
		Abhydrolase_5	<368..419	CDD:289465	19/50 (38%)
Lipo3	NP_001013792.2	PLN02872	34..391	CDD:215470	132/363 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2905
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8736
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810