DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and LIPM

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	XP_011538050.1	Gene:	LIPM / 340654	HGNCID:	23455	Length:	430	Species:	Homo sapiens

Alignment Length:	392	Identity:	138/392 - (35%)
Similarity:	221/392 - (56%)	Gaps:	28/392 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRIAR-------PGATP-VLLVHGLL 129
            |||    ::.:|...:|:..|||.|.:.:.|:|||||:::||.|       .|:.| |||.|||:
Human    41 VDP----EAFMNISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLV 101

  Fly   130 DSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPA 194
            ..::.|:...||..||::|.|.|:||||.|.|||.:||||...|....:||.|::.||.:.|:||
Human   102 GGASNWISNLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPA 166

  Fly   195 TMDYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAE 259
            .:::||..||..:::|:|:||||.:.:|..|..||...||.:...|||:|.:||.:||...||
Human   167 VINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATVKHAKSPGTKFL-- 229

  Fly   260 WHLSVSLVLK-LIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLN------ 317
              |...:::| |.|..|||.:..|:......:|.: .|..:||||::.|..||:...:|
Human   230 --LLPDMMIKGLFGKKEFLYQTRFLRQLVIYLCGQ-VILDQICSNIMLLLGGFNTNNMNMNTHGL 291

  Fly   318 -ETMLPVIVGHSPAGASTKQMQHFGQLNRSGGFRQYDHG-WLRNHWIYGTIDPPSYHLENVRAKV 380
             ::...|...|:.||.|.:.:.|:.|...||..|.:|.| ..:|........|..|.:.::....
Human   292 LQSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKCNQPTPVRYRVRDMTVPT 356

  Fly   381 ALYYGQNDWLAPPEDVEMLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIMRNHEN 445
            |::.|..|||:.||||:||..::.|::  |..:..|:.|:|||||:||...:::.::.:|:..|.
Human   357 AMWTGGQDWLSNPEDVKMLLSEVTNLI--YHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMQQEET 419

  Fly   446 SI 447
            ::
Human   420 NL 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	134/374 (36%)
		Abhydro_lipase	88..139	CDD:282003	23/58 (40%)
		Abhydrolase_5	121..>253	CDD:289465	59/132 (45%)
		Abhydrolase_5	<368..419	CDD:289465	16/50 (32%)
LIPM	XP_011538050.1	Abhydro_lipase	49..111	CDD:282003	23/61 (38%)
		Abhydrolase_1	92..399	CDD:278959	113/313 (36%)
		Abhydrolase_5	93..>231	CDD:289465	61/141 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H28267
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840