DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and SPBC16A3.12c

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_596777.1	Gene:	SPBC16A3.12c / 2539875	PomBaseID:	SPBC16A3.12c	Length:	443	Species:	Schizosaccharomyces pombe

Alignment Length:	383	Identity:	109/383 - (28%)
Similarity:	181/383 - (47%)	Gaps:	51/383 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NTYSLIKKYGYPAENHTLETDDGYILTLHRIARPGATP-----VLLVHGLLDSSATWVMMGPN-K 142
            |.|.:.:.:||..|.|.:.|.|.:||.||||..|..:.     |...|||:.:|..||.:..: :
pombe    74 NIYEICEAFGYRVEEHLVRTQDNFILCLHRITHPKQSQHKREVVYCHHGLMTNSELWVAVNESER 138

  Fly   143 GLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPATMDYILNSTGVSQ 207
            .|.::|.:.|||||:.|.|||.|||||:.|.....:||:|:..:|...|||.|:||||..||..:
pombe   139 SLPFVLIESGYDVWLGNNRGNKYSRKHITYKPKDEEFWNFSLDDMAMFDIPDTVDYILRETGREK 203

  Fly   208 LHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAEWHLSVSLVLKLIG 272
            |:|||.||||.......|..|:..||:.:..||||.    :......|:..::.:.|:
pombe   204 LNYIGFSQGTAQAMAALSINPDLNDKVNIFIGLAPA----YAPKGFSNYFVDYIVKVN------- 257

  Fly   273 VHEFLPKNEFISMFNRIICDETTITKEICSNVIFL-----------TTGFDKLQLNETMLPVIVG 326
                 ||..:.....|.:....|..:.||...||:           ......:.||:.:..  ..
pombe   258 -----PKIMYHLFGRRCLLPSVTFWQNICYPPIFVKIVDVSLKILFNWDLSNISLNQKLCG--YA 315

  Fly   327 HSPAGASTKQMQHFGQLNRSGGFRQYDH------GWLRNHWIYGTIDPPSYHLENVRAKVALYYG 385
            |..:.:|.|.:.|:.|:.::..|:.||.      |:...|:     ..|.:...|::..:.:.:|
pombe   316 HLYSFSSVKSVVHWLQIIKNCTFQLYDDDMALLAGYGSRHY-----QVPLFPTNNIKCPMLILWG 375

  Fly   386 QNDWLAPPEDVEMLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIMRNH 443
            ..|.|.   ::|::...||...::  |....:.||||:||.|.:|.::..:::.:::|
pombe   376 GKDTLI---NMEVMRTALPPHAKE--VSIAHYEHLDFLWGQDVKEEVFPVVIDALKHH 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	107/379 (28%)
		Abhydro_lipase	88..139	CDD:282003	20/55 (36%)
		Abhydrolase_5	121..>253	CDD:289465	54/137 (39%)
		Abhydrolase_5	<368..419	CDD:289465	9/50 (18%)
SPBC16A3.12c	NP_596777.1	Abhydro_lipase	75..131	CDD:282003	19/55 (35%)
		Abhydrolase_1	116..410	CDD:278959	89/321 (28%)
		Abhydrolase	<171..>242	CDD:304388	30/74 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	133	1.000	Domainoid score	I1290
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1188
OMA	1	1.010	-	-		QHG55134
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm9260
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
TreeFam	0	0.000	Not matched by this tool.
	11	10.800