DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and SPBC14C8.15

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_595918.1	Gene:	SPBC14C8.15 / 2539842	PomBaseID:	SPBC14C8.15	Length:	460	Species:	Schizosaccharomyces pombe

Alignment Length:	406	Identity:	111/406 - (27%)
Similarity:	187/406 - (46%)	Gaps:	69/406 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PNIQEDSHLN-------TYSLIKKYGYPAENHTLETDDGYILTLHRIARPG---------ATPVL 123
            |.:..|.:.|       |..|...:||..|.|.:.|.|||:|.|||:.:..         ..|||
pombe    58 PELLVDDNANKLTDARDTIDLCALHGYDLEEHFVRTTDGYLLGLHRVYKKKKGKIEELNYLPPVL 122

  Fly   124 LVHGLLDSSATWVM-MGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEM 187
            .:|||:.:|.:||. :.....:.:.|.:||||||:.|:|||.||.|::|:|:.:.|||||:...:
pombe   123 FIHGLMMNSESWVCNLKKEDAIPFALVEQGYDVWLGNLRGNKYSIKNIKFSSQNPKFWDFSLDSI 187

  Fly   188 GKHDIPATMDYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAP-VAFLKHCRS 251
            ...|||:.:.|||:......:..:|.|||.::.:...|...|..:.:.....||| :|..|:...
pombe   188 AIFDIPSIVKYILSVNSFDSISLVGFSQGAILAFAALSIDTELRNSVRAFIALAPAIAPKKYSGR 252

  Fly   252 PVVNFLAEWHLSVSLVLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVI------FLT-T 309
            .|.:.:   |.:..|:..:.|      :|   ||....:..:..:...:.:.::      ||: |
pombe   253 TVKSII---HANSQLLYLMFG------RN---SMLGSAVFWQAVLYPPVFAKIVDLFLRFFLSWT 305

  Fly   310 GFDKLQLNETMLPVIVGHSPAGASTKQMQHFGQLNRSGGFRQYDH--GWLRNHWIYGTIDPPSYH 372
            |   ..::||...|...|..:..|.|...|:.|:.|....:.||.  |:           .|||:
pombe   306 G---KNISETQKIVAYSHLYSFTSVKCFVHWAQITRRKVLQMYDDSPGF-----------KPSYY 356

  Fly   373 ----------LENVRAKVALYYGQNDWLAPPEDVEMLNRKLPNVVEKYLVDDKEFNHLDFIWGID 427
                      :||:|..:.|.||.||.:.   |:|.|..:||.:.:  .:....:.|||.|.|..
pombe   357 TNLNRIARYPIENIRLPITLVYGSNDNMV---DIETLKTQLPPLSQ--CIQIPNYEHLDIIMGDT 416

  Fly   428 ARELLWDRMLEIMRNH 443
            .::::..:::|.: ||
pombe   417 KKDIVIQQVVEQL-NH 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	107/386 (28%)
		Abhydro_lipase	88..139	CDD:282003	22/60 (37%)
		Abhydrolase_5	121..>253	CDD:289465	47/133 (35%)
		Abhydrolase_5	<368..419	CDD:289465	16/60 (27%)
SPBC14C8.15	NP_595918.1	Abhydro_lipase	75..138	CDD:282003	23/62 (37%)
		Abhydrolase_1	119..412	CDD:278959	89/323 (28%)
		Abhydrolase_5	120..>260	CDD:289465	48/142 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	133	1.000	Domainoid score	I1290
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1188
OMA	1	1.010	-	-		QHG55134
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm9260
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
TreeFam	0	0.000	Not matched by this tool.
	10	9.770