DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lip4 and Lipk

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001192278.1	Gene:	Lipk / 240633	MGIID:	2679259	Length:	403	Species:	Mus musculus

Alignment Length:	436	Identity:	148/436 - (33%)
Similarity:	220/436 - (50%)	Gaps:	59/436 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LIALSLCLLQSGIVEGISLSLGDITLFNVNFKTPTFLGRSVAVDSNVRLENDVDPNIQEDSHLNT 85
            |:|.:.|:|.||.::|                              .:.|:..:|    ::::|.
Mouse     4 LLATTCCVLLSGPIDG------------------------------YKQESITNP----EANMNI 34

  Fly    86 Y-----SLIKKYGYPAENHTLETDDGYILTLHRI---------ARPGATPVLLVHGLLDSSATWV 136
            .     .||..:|||.|.|.:.|:|||||..:||         ..|.|. |.|.|||:.|:..|:
Mouse    35 VCVFQSELISYWGYPYEKHDVITEDGYILGTYRIPHGKGCSRKTAPKAV-VYLQHGLIASANNWI 98

  Fly   137 MMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPATMDYILN 201
            ...||..|.:||.|.|||||:.|.||||:||.|::.|....::|.|::.||.|:|:|||::.||.
Mouse    99 CNLPNNSLAFLLADSGYDVWLGNSRGNTWSRNHLRLSPKSPQYWAFSWDEMAKYDLPATVNLILE 163

  Fly   202 STGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAEWHLSVSL 266
            .:|..||.|:||||||.:.:|..|..||...||.|...|||||.:|:.|||:.....   ||...
Mouse   164 KSGQKQLFYVGHSQGTTIAFIAFSTNPELAKKIRLFFALAPVATVKYTRSPMKKLTT---LSRKA 225

  Fly   267 VLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETMLPVIVGHSPAG 331
            |..|.|...|.....|.......:|:. .:..::|||.:|..:|||...||.:.|.|.:..||||
Mouse   226 VKVLFGDKMFSTHTWFEQFIATKVCNR-KLFHQLCSNFLFSLSGFDPQNLNMSRLDVYLSQSPAG 289

  Fly   332 ASTKQMQHFGQLNRSGGFRQYDHGWL-RNHWIYGTIDPPSYHLENVRAKVALYYGQNDWLAPPED 395
            .|.:.|.|:.|...||..:.:|.|.. :|...:..:.||.|::..:|...|::.|..|.:|..:|
Mouse   290 TSVQNMLHWAQAVNSGQLQAFDWGNPDQNMMHFNQLTPPVYNISKMRVPTAMWSGGQDVVADAKD 354

  Fly   396 VEMLNRKLPNVVEKYLVDDKEFNHLDFIWGIDA-RELLWD--RMLE 438
            .:.|..|:.|::  |..:...:||:||..|.|| :|:..|  ||:|
Mouse   355 TKNLLPKIANLI--YYKEIPHYNHMDFYLGQDAPQEVYGDLIRMIE 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	138/364 (38%)
		Abhydro_lipase	88..139	CDD:282003	24/59 (41%)
		Abhydrolase_5	121..>253	CDD:289465	63/131 (48%)
		Abhydrolase_5	<368..419	CDD:289465	13/50 (26%)
Lipk	NP_001192278.1	Abhydro_lipase	40..101	CDD:282003	24/61 (39%)
		Abhydrolase_5	82..>210	CDD:289465	61/128 (48%)
		Abhydrolase_1	83..382	CDD:278959	113/305 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2905
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8736
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.840