DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and lipl-6

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_504755.3	Gene:	lipl-6 / 179081	WormBaseID:	WBGene00021963	Length:	591	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	138/381 - (36%)
Similarity:	217/381 - (56%)	Gaps:	18/381 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRIAR--------PGATP---VLLVH 126
            :||    ::.::...:|..:|||.|.|.:.|.||||||||||..        ...||   |.|.|
Worm   174 IDP----EALMDVPEIITHWGYPVETHKVVTVDGYILTLHRIPHGKNETSKSASKTPKPVVFLQH 234

  Fly   127 GLLDSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHD 191
            |||.:|:.|::..|.:..||:..|||||||:.|:||||||::|.:.::...:||.|::.||.::|
Worm   235 GLLCTSSIWLLNLPRQSAGYIFADQGYDVWLGNMRGNTYSKEHTRMTSADRRFWKFSWEEMARYD 299

  Fly   192 IPATMDYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNF 256
            :||.::|.|.:|....|:|:|||||.:..:...||.||...||.....:||||.:.|.:....|
Worm   300 LPAMINYALKTTKRQNLYYVGHSQGALTMFAKMSEDPEMSKKIRKFFAMAPVARMSHVKGLFQN- 363

  Fly   257 LAEWHLSVSLVLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETML 321
            |.:.:...:||.::.|..|||..|.|..:...|.||: .:...:|.|.||..:|.:..|.|.:.:
Worm   364 LGQIYEQYNLVYQVFGDGEFLTNNIFTKLLTDIFCDQ-AVNNPLCENFIFAVSGPNSNQFNNSRI 427

  Fly   322 PVIVGHSPAGASTKQMQHFGQLNRSGGFRQYDHGWLRNHWIYGTIDPPSYHLENVRAKVALYYGQ 386
            .:.:.|:|||.|::.:.||.|:.:.....::|||...|..|||...||.|.:..:.:.:.|:|..
Worm   428 GIYLAHNPAGTSSRNILHFAQMVKKKRMSRFDHGKDLNLKIYGAPSPPEYDIRKINSSIYLFYSD 492

  Fly   387 NDWLAPPEDVE-MLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIMR 441
            .||||.|:||| .|...||:...|.....::|||.||:||:.||:.::|:::..::
Worm   493 FDWLANPKDVEGFLIPMLPSKTLKKATKLRDFNHNDFLWGMRARKEIYDKIINTIK 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	136/366 (37%)
		Abhydro_lipase	88..139	CDD:282003	27/61 (44%)
		Abhydrolase_5	121..>253	CDD:289465	56/134 (42%)
		Abhydrolase_5	<368..419	CDD:289465	18/51 (35%)
lipl-6	NP_504755.3	PLN02872	184..544	CDD:215470	136/361 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm4823
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.860