DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrr47 and Lrr1

DIOPT Version :9

Sequence 1:	NP_001260355.1	Gene:	Lrr47 / 34449	FlyBaseID:	FBgn0010398	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001074875.1	Gene:	Lrr1 / 69706	MGIID:	1916956	Length:	422	Species:	Mus musculus

Alignment Length:	432	Identity:	136/432 - (31%)
Similarity:	205/432 - (47%)	Gaps:	57/432 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKILCEVQVVNRATQT------NKTPRPVKSTL-AIGYKQSARDANGNTKKELEMVLFSGQNKTG 58
            |::.|||:|.:....|      .|..|.|.|.. |.|..:...:|.........:::.:.:::.|
Mouse     1 MRLPCEVEVRSCHLPTLGLKSRGKGVRAVVSLCQAPGRNELQPEARAEPGGHACLLVSTMKDRQG 65

  Fly    59 NRYKVKDNIHVVHTKFVLDGKTTIGFIQPP-DNLLIKCDPIQLKGFLQTLKLGMDGKDAINLRLN 122
            ..||:::||..:.||||.:||.|:...:|| |..|.|.:|..||..|..::|...|.|     :|
Mouse    66 TSYKLRENIEQLFTKFVDEGKATVRLKEPPVDICLSKANPGNLKTLLSAMRLAHRGCD-----VN 125

  Fly   123 INAATAIPQKAQP----QVRMVISKRSEYPI-KGFPRTLKSLTINNSQLVKLSFEICTLRNLTKL 182
            ...:|..|.|...    :.:|||:.:.:||: |.||..|:.|..:...|.::...:..|:|||||
Mouse   126 TPLSTLKPVKTSEFEKYKTKMVITSKKDYPLSKNFPYFLEHLQASYCSLARVDMRMLCLKNLTKL 190

  Fly   183 DVSGNKLTKIPSELGRLP-LTSLHLGNNLLGTQNDWCWLRGTKLC-----QSLGELDLSGNGLTY 241
            |:|.|.:.|:|:.:|.|. |..|:|.:|.|.|.:       ..||     :||..||||.|.:..
Mouse   191 DLSHNCIKKLPATIGDLTHLQELNLNDNQLETFS-------VPLCTSTLQKSLHSLDLSKNKIKA 248

  Fly   242 FPPPLVKFESLVSLNLNNNLLSRLPFAIRRMKALRKLYVCSNELESLPSAVEDLRIDLLDVWGNC 306
            .|....:|..|.:||||:|.|..|||.|.::..||.|....|:|.:|||..:.|.::.||::||.
Mouse   249 LPVQFCQFRELTNLNLNDNELIHLPFKIGQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGNT 313

  Fly   307 FKEFNADAAQQMYLQKAASNSPQPLWLLGA--RAVDKYMLPLSAGSIPAVLIDLIREAPRCPCGE 369
            |::  .:....:.||       .||.||.:  :||..|.:|.....||..|...:..|..|.||.
Mouse   314 FEK--PEVIPIIKLQ-------VPLTLLESCEQAVLFYRIPYGPDIIPYHLCQDLDTAKTCVCGR 369

  Fly   370 LCYAQRKEDLFQRVVQPKFITVKNLTYSREHQIYADVVLCDS 411
            .|        .|..:|.  .|..||     |.:...|||.||
Mouse   370 FC--------LQSFIQG--TTTMNL-----HSVAHTVVLVDS 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrr47	NP_001260355.1	LRR_8	154..211	CDD:290566	20/57 (35%)
		LRR_4	156..194	CDD:289563	13/37 (35%)
		leucine-rich repeat	156..178	CDD:275380	4/21 (19%)
		leucine-rich repeat	179..199	CDD:275380	10/19 (53%)
		leucine-rich repeat	201..228	CDD:275380	8/31 (26%)
		leucine-rich repeat	229..274	CDD:275380	19/44 (43%)
		leucine-rich repeat	275..298	CDD:275380	9/22 (41%)
Lrr1	NP_001074875.1	leucine-rich repeat	164..186	CDD:275380	4/21 (19%)
		LRR_RI	<184..269	CDD:238064	36/91 (40%)
		LRR_8	185..246	CDD:290566	27/67 (40%)
		leucine-rich repeat	187..209	CDD:275380	11/21 (52%)
		leucine-rich repeat	210..235	CDD:275380	8/31 (26%)
		LRR_8	234..292	CDD:290566	24/57 (42%)
		leucine-rich repeat	236..258	CDD:275380	8/21 (38%)
		leucine-rich repeat	259..281	CDD:275380	11/21 (52%)
		leucine-rich repeat	282..303	CDD:275380	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845936
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9TQ
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32677
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4357
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48628
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007359
OrthoInspector	1	1.000	-	-		oto94411
orthoMCL	1	0.900	-	-		OOG6_108324
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3791
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.690