DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrr47 and Lrr1

DIOPT Version :9

Sequence 1:	NP_001260355.1	Gene:	Lrr47 / 34449	FlyBaseID:	FBgn0010398	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001102953.1	Gene:	Lrr1 / 685860	RGDID:	1589026	Length:	422	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	130/432 - (30%)
Similarity:	211/432 - (48%)	Gaps:	57/432 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKILCEVQVVNRATQT---NKTPRPVKSTLAIGYKQSARDANGNTKKELE----MVLFSGQNKTG 58
            |::.|||:|.:....|   ....:.|::.:::....|..:.....:.|..    :::.:.:::.|
  Rat     1 MRLPCEVEVRSCHLPTLGLKSRGKGVRAVVSLCQAPSKNELQPGARTETSGCACLLVSTMKDRQG 65

  Fly    59 NRYKVKDNIHVVHTKFVLDGKTTIGFIQPP-DNLLIKCDPIQLKGFLQTLKLGMDGKDAINLRLN 122
            .||::::||..:.||||.:||.|:...:|| |..|.|.:|..||.||..::|...|.|     :|
  Rat    66 TRYRLRENIEQLFTKFVDEGKATVRLKEPPVDICLSKANPGNLKTFLSAMRLAHRGSD-----VN 125

  Fly   123 INAATAIPQKAQP----QVRMVISKRSEYPI-KGFPRTLKSLTINNSQLVKLSFEICTLRNLTKL 182
            ...:|..|.|...    :.:|:|:.:.:||: |.||.:|:.|..::.:|.::...:..|::||||
  Rat   126 TPLSTLKPVKTSEFEKFKTKMIITSKKDYPLSKNFPYSLEHLQASHCRLARVDMRMLCLKSLTKL 190

  Fly   183 DVSGNKLTKIPSELGRLP-LTSLHLGNNLLGTQNDWCWLRGTKLC-----QSLGELDLSGNGLTY 241
            |:|.|.:.|:|:.:|.|. |..|:|.:|.|.:.:       ..||     :||..||||.|.:..
  Rat   191 DLSHNCIKKLPATIGDLTHLQELNLSDNQLESFS-------VPLCKSTLQKSLQSLDLSKNKIKA 248

  Fly   242 FPPPLVKFESLVSLNLNNNLLSRLPFAIRRMKALRKLYVCSNELESLPSAVEDLRIDLLDVWGNC 306
            .|....:|..|.:||||:|.|..|||.|.|:..||.|....|:|.:||...:.|.::.||::||.
  Rat   249 LPVQFCQFRELTNLNLNDNELIHLPFKIGRLTNLRFLSAARNKLRNLPCEFKMLSLEYLDLFGNT 313

  Fly   307 FKEFNADAAQQMYLQKAASNSPQPLWLLGA--RAVDKYMLPLSAGSIPAVLIDLIREAPRCPCGE 369
            |::  .:....:.||       .||.||.|  :||..|.:|.....||..|...:..|..|.||.
  Rat   314 FEK--PEVLPIINLQ-------VPLTLLEACEQAVLSYRIPYGPDIIPYHLCQDLDTAKTCVCGR 369

  Fly   370 LCYAQRKEDLFQRVVQPKFITVKNLTYSREHQIYADVVLCDS 411
            .|        .|..:|.  .|..||     |.:...|||.|:
  Rat   370 FC--------LQSFIQG--TTTMNL-----HSLAHTVVLIDT 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrr47	NP_001260355.1	LRR_8	154..211	CDD:290566	19/57 (33%)
		LRR_4	156..194	CDD:289563	12/37 (32%)
		leucine-rich repeat	156..178	CDD:275380	4/21 (19%)
		leucine-rich repeat	179..199	CDD:275380	10/19 (53%)
		leucine-rich repeat	201..228	CDD:275380	7/31 (23%)
		leucine-rich repeat	229..274	CDD:275380	20/44 (45%)
		leucine-rich repeat	275..298	CDD:275380	8/22 (36%)
Lrr1	NP_001102953.1	LRR_RI	<162..314	CDD:238064	55/158 (35%)
		LRR_8	163..220	CDD:290566	19/56 (34%)
		leucine-rich repeat	164..186	CDD:275380	4/21 (19%)
		leucine-rich repeat	187..209	CDD:275380	11/21 (52%)
		LRR_8	208..269	CDD:290566	22/67 (33%)
		leucine-rich repeat	210..235	CDD:275380	7/31 (23%)
		leucine-rich repeat	236..258	CDD:275380	8/21 (38%)
		leucine-rich repeat	259..281	CDD:275380	12/21 (57%)
		leucine-rich repeat	282..303	CDD:275380	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9TQ
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32677
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4208
OMA	1	1.010	-	-		QHG48628
OrthoDB	1	1.010	-	-		D1397717at2759
OrthoFinder	1	1.000	-	-		FOG0007359
OrthoInspector	1	1.000	-	-		oto97926
orthoMCL	1	0.900	-	-		OOG6_108324
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.670