DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrr47 and lrr1

DIOPT Version :9

Sequence 1:	NP_001260355.1	Gene:	Lrr47 / 34449	FlyBaseID:	FBgn0010398	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_996968.1	Gene:	lrr1 / 404617	ZFINID:	ZDB-GENE-040426-2337	Length:	436	Species:	Danio rerio

Alignment Length:	452	Identity:	139/452 - (30%)
Similarity:	212/452 - (46%)	Gaps:	64/452 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKILCEVQVVNRATQT---NKTPRPVKSTLAIGYKQSARDA-----NGNTK-----KELEMVLFS 52
            ||:.|:|:|:||...:   ....|..::.|:||..:..|.|     ||:|.     ..|.:::.:
Zfish     1 MKLQCDVEVINRMLPSCGLKSKGRSSRAVLSIGRPERERAAPSTGSNGSTSTGSSGSGLHLLICT 65

  Fly    53 GQNKTGNRYKVKDNIHVVHTKFVLDGKTTIGFIQPP-DNLLIKCDPIQLKGFLQTLKLGMDGKDA 116
            .::::|.:||:|:|:....|.||.:||.|:...:|. |..|.|.|...||.||..::|...|..|
Zfish    66 SRDRSGAKYKLKENVEKFFTWFVEEGKATVRLKEPAIDICLSKADVTSLKSFLSAVRLAQRGAAA 130

  Fly   117 INLRLNINAATAIPQKA----QPQVRMVISKRSEYPI-KGFPRTLKSLTINNSQLVKLSFEICTL 176
            ..   .:..:...|.:|    :|:.::.:..|.:||: :.||..|:.|.::..||.::...:.:|
Zfish   131 AG---GVPLSALCPVRAREVEKPKQKLTVLSRRDYPLTRSFPPALQQLQVSYCQLSRVDLRVLSL 192

  Fly   177 RNLTKLDVSGNKLTKIPSELGRL-PLTSLHLGNNLLGTQNDWCWLRGTKLC-----QSLGELDLS 235
            |.|.:||:|.|::..:|:.||.| .|..|.|.||.|....|       :||     .||..||||
Zfish   193 RALRRLDLSNNRIRALPAGLGDLRALAELVLHNNQLERFGD-------ELCCSGLQTSLRLLDLS 250

  Fly   236 GNGLTYFPPPLVKFESLVSLNLNNNLLSRLPFAIRRMKALRKLYVCSNELESLPSAVEDLRIDLL 300
            .|.|...|....:...||:|.|::|.|.||||.:.|:.|||.|....|:|..||.....||:|.|
Zfish   251 HNLLPALPARFCQLRQLVTLRLDHNRLQRLPFHLGRLSALRFLSAAHNQLPVLPDGFRSLRLDTL 315

  Fly   301 DVWGNCFKEFNADAAQQMYLQ-KAASNSPQPLWLLGARAVDKYMLPLSAGSIPAVLIDLIRE--- 361
            |::||.|       |:...|| :.....|..|..|.||.|..:.:|.|...:|   :.|.||
Zfish   316 DLFGNPF-------ARAHTLQPRMLITLPLTLQELAARTVLDHRVPHSPQLLP---LHLCRELDF 370

  Fly   362 APRCPCGELCYAQRKEDLFQRVVQPKFITVKNLTYSREHQIYADVVLCDSRCSASAELKLLF 423
            :..|.||.:|.    ....|..|.      .||     ||:...|||.|:.....|.:...|
Zfish   371 SSVCVCGRVCV----NAFIQTAVS------FNL-----HQVAHTVVLVDNMGGTEAPVHTHF 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrr47	NP_001260355.1	LRR_8	154..211	CDD:290566	20/57 (35%)
		LRR_4	156..194	CDD:289563	11/37 (30%)
		leucine-rich repeat	156..178	CDD:275380	5/21 (24%)
		leucine-rich repeat	179..199	CDD:275380	8/19 (42%)
		leucine-rich repeat	201..228	CDD:275380	9/31 (29%)
		leucine-rich repeat	229..274	CDD:275380	19/44 (43%)
		leucine-rich repeat	275..298	CDD:275380	9/22 (41%)
lrr1	NP_996968.1	LRR_RI	<166..>267	CDD:238064	35/107 (33%)
		leucine-rich repeat	172..194	CDD:275380	5/21 (24%)
		LRR_8	193..254	CDD:290566	26/67 (39%)
		leucine-rich repeat	195..217	CDD:275380	9/21 (43%)
		leucine-rich repeat	218..243	CDD:275380	9/31 (29%)
		leucine-rich repeat	244..266	CDD:275380	8/21 (38%)
		LRR_8	265..322	CDD:290566	26/56 (46%)
		leucine-rich repeat	267..289	CDD:275380	11/21 (52%)
		leucine-rich repeat	290..310	CDD:275380	7/19 (37%)
		leucine-rich repeat	312..339	CDD:275380	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32677
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4746
OMA	1	1.010	-	-		QHG48628
OrthoDB	1	1.010	-	-		D1397717at2759
OrthoFinder	1	1.000	-	-		FOG0007359
OrthoInspector	1	1.000	-	-		oto40216
orthoMCL	1	0.900	-	-		OOG6_108324
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.810