DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrr47 and Lrrd1

DIOPT Version :9

Sequence 1:	NP_001260355.1	Gene:	Lrr47 / 34449	FlyBaseID:	FBgn0010398	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_216085.3	Gene:	Lrrd1 / 296836	RGDID:	1562785	Length:	855	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	91/403 - (22%)
Similarity:	169/403 - (41%)	Gaps:	79/403 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QSARDANGNTKKELEM------------VLFSGQNKTGNRYKVKDNIHVVHTKFVLDGKTTIGFI 85
            ::.|..:.|..|.::|            :.|||...|....::|:...:  |:..|:....:.|
  Rat   414 KNLRQLHANRNKMIKMAEEISHLSKIHSLEFSGNQITHVPIEIKNCKEI--TRVELNYNNIMYF- 475

  Fly    86 QPPDNL--LIKCDPIQLKG-FLQTLKLGMD-GKDAINLRLNINAATAIPQKAQPQVRMVISKRSE 146
              |..|  |...|.:...| ::..:.:.:. .|..::|.||.|..|...:.......:.....::
  Rat   476 --PVGLCALQSLDYLSFNGNYISEIPVDLSFSKQLLHLELNKNKITIFSEHLCSLTNLEYLDLAK 538

  Fly   147 YPIKGFPR------TLKSLTINNSQLVKLSFEICTLRNLTKLDVSGNKLTKIPSELGRL-PLTSL 204
            ..|:..|.      :|..|.:::::......|:|:|:||..||:|.|:|.|||||:.:| .:..|
  Rat   539 NQIRKIPHCISAMLSLHVLILSDNKFEIFPKELCSLKNLQLLDISENQLHKIPSEISKLKKIQKL 603

  Fly   205 HL-GNNLLGTQNDWCWLRGTKLCQSLGELD---LSGNGLTYFPPPLVKFESLVSLNLNNNLLSRL 265
            :| .||......:.|.|      |:|.:|:   :||..||..|..:.:...|.:||::||.:..:
  Rat   604 NLSNNNFTHFPAELCQL------QTLEDLNISQISGKKLTRLPEEVSRMTQLKALNISNNAIKEI 662

  Fly   266 PFAIRRMKALRKLYVCSNELESLPSAVEDLRI-DLLDVWGNCFKEFNADAAQQMYLQKAASNSPQ 329
            |..|..::.|...:..:|::.||||:...|.: ..||:.||...:.                 |.
  Rat   663 PRNIGELRNLITFHASNNQINSLPSSFLSLNVLQSLDLGGNNLTDL-----------------PS 710

  Fly   330 PLWLLGARAVDKYMLPLSAGSIPAVLID---LIREAPRCPCGE-----LCYAQRKEDLFQRVVQP 386
            .::.|              .|:..:..|   |:|.......|:     .||.||.:|..:::::.
  Rat   711 AIYKL--------------SSLKEINFDDNPLLRPPMEICKGKQMHTITCYLQRADDRDEKILEK 761

  Fly   387 KF-ITVKNLTYSR 398
            .| |...|:|.::
  Rat   762 IFHIVANNITETK 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrr47	NP_001260355.1	LRR_8	154..211	CDD:290566	22/64 (34%)
		LRR_4	156..194	CDD:289563	14/37 (38%)
		leucine-rich repeat	156..178	CDD:275380	5/21 (24%)
		leucine-rich repeat	179..199	CDD:275380	11/19 (58%)
		leucine-rich repeat	201..228	CDD:275380	6/27 (22%)
		leucine-rich repeat	229..274	CDD:275380	14/47 (30%)
		leucine-rich repeat	275..298	CDD:275380	7/23 (30%)
Lrrd1	XP_216085.3	leucine-rich repeat	162..185	CDD:275380
		LRR_8	185..242	CDD:290566
		leucine-rich repeat	186..208	CDD:275380
		leucine-rich repeat	209..231	CDD:275380
		leucine-rich repeat	232..254	CDD:275380
		LRR_RI	253..564	CDD:238064	27/154 (18%)
		LRR_8	253..311	CDD:290566
		leucine-rich repeat	255..277	CDD:275380
		leucine-rich repeat	278..300	CDD:275380
		LRR_8	299..357	CDD:290566
		leucine-rich repeat	301..323	CDD:275380
		leucine-rich repeat	324..346	CDD:275380
		leucine-rich repeat	347..392	CDD:275380
		leucine-rich repeat	439..461	CDD:275380	5/21 (24%)
		leucine-rich repeat	463..484	CDD:275380	6/23 (26%)
		leucine-rich repeat	487..507	CDD:275380	1/19 (5%)
		leucine-rich repeat	508..530	CDD:275380	5/21 (24%)
		leucine-rich repeat	531..553	CDD:275380	2/21 (10%)
		LRR_RI	537..>728	CDD:238064	56/227 (25%)
		LRR_8	553..610	CDD:290566	21/56 (38%)
		leucine-rich repeat	554..576	CDD:275380	5/21 (24%)
		leucine-rich repeat	577..599	CDD:275380	12/21 (57%)
		leucine-rich repeat	600..648	CDD:275380	14/53 (26%)
		leucine-rich repeat	649..671	CDD:275380	7/21 (33%)
		LRR_8	670..728	CDD:290566	15/88 (17%)
		leucine-rich repeat	672..694	CDD:275380	7/21 (33%)
		leucine-rich repeat	695..717	CDD:275380	6/52 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910