Protein Alignment Myo31DF and MYO1

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1113
• Identity: 317/1113 - (28%)
• Similarity: 523/1113 - (46%)
• Gaps: 231/1113 - (20%)

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGR------ 67
            |::...|..::....:.||.||:....||||.|...|::|||..:|:|..:.|..|..:
Yeast    77 VENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSK 141

  Fly    68 -ELFENA-----PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTN---- 122
             .|.||:     ||:||||:.||..|....:|..||::|||||||||.:|.|::|:|::|:
Yeast   142 SRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPS 206

  Fly   123 ----AQGQNEIERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYL 183
                ..|.:.:|..:..::|||.|||:||||:|.||:|||||||::.|||:......|..|..||
Yeast   207 NIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYL 271

  Fly   184 LEKSRVVQQQPGERNFHSFYQLLRGANDNELRQYELQKETGK-YHYLNQGSMDI---LTEKSDYK 244
            |||||:|.|...|||:|.|||||.|.:|:||:...|:....| |..|:..:.||   :.:..::|
Yeast   272 LEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFK 336

  Fly   245 GTCNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELST 309
            ...:|...:|||.|:::.|::.:|.:|.:||:||.:...|.. |.|..:.:....|.|.|.:..|
Yeast   337 ELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDRAEQA-SFKNDVSAICSNLGVDEKDFQT 400

  Fly   310 ALTKRVIAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVI 374
            |:.:....||...:.:..|:.||::..:||::.:|:|||.:|:..||:. |..||.|.    :.|
Yeast   401 AILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKN-LDHGSATL----NYI 460

  Fly   375 GVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNN-KIICD 438
            |:|||.|||||::|||||.||||.||||||.|...:...||.||.:|.|:|..|:|..: ::..|
Yeast   461 GLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTID 525

  Fly   439 LVEQ--PHKGIIAIMDEACLSVGKVTDDT----LLGAMDKNLSKHPHYTSRQLKPTDKELKHRED 497
            |:|.  |..|::.::||..: :.|.||::    |:...|:|.||.            |..:.:..
Yeast   526 LIESKGPPTGVLPLLDEEAV-LPKSTDESFYSKLISTWDQNSSKF------------KRSRLKNG 577

  Fly   498 FRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMW-PEGA-------------QD 548
            |.:.||||||.|.:.|::.||||.|..:...||.:|::..:|::: |||.             |:
Yeast   578 FILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQE 642

  Fly   549 IKKTTKRPL--TAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLL 611
            :||:.:...  |..:..:.....|:..|....|.:||||.||::|....|:...:..|:|..|:|
Yeast   643 VKKSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVL 707

  Fly   612 ENLRVRRAGFVHRQRYDKFLLRYKMI-----SQYTWPNFRAGSDRDGVRVLIEEKKFAQDV-KYG 670
            |.:|:.|.|:.:|..:.:|..||:::     :..|:.:....|.:.....|:...:....| |.|
Yeast   708 EGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIG 772

  Fly   671 HTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYV 735
            :||:|.:: ..|..||.|::..:.:|:..|...:||:.||:
Yeast   773 NTKLFFKA-GVLADLEKQKDVKLNNIMIKLTATIRGYTVRK------------------------ 812

  Fly   736 QELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQII 800
             |:...|:|.|:.|..|.:.                 |::     |.::.:.|   |..|.::|
Yeast   813 -EITYHLQKLKKTRVIGNTF-----------------RLY-----NRLVKEDP---WFNLFIRI- 850

  Fly   801 AATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFN 865
                    :|           .|.:|.:.:..:.:|..|..::|...:.|:.::.|.....|..|
Yeast   851 --------KP-----------LLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVN 896

  Fly   866 HF------------NKQANRAFI----VSDSTIHK----------------------LDGIKNKF 892
            ..            |.:.|.:.:    .|..|:.|                      |:....|.
Yeast   897 ELENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQKI 961

  Fly   893 KDMKRTIKIRELTSISVSPGRDQLIVFHSSKN-------------KDLVFSLESEYTPL------ 938
            :.::.||:.||.|...:....::||...|..|             |:....||:|...|
Yeast   962 QGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINS 1026

  Fly   939 KEDRIGEVVGIVCKKYHD-LTGTELRVNVTTNISCRLDGKARIITVEAASNV----------EVP 992
            ||:.|        |.::| |:.:|..:::            :::|:|...|:          |..
Yeast  1027 KEEEI--------KSFNDKLSSSEEDLDI------------KLVTLEKNCNIAMSRLQSLVTENS 1071

  Fly   993 NFRPKEGN 1000
            :.|.|..|
Yeast  1072 DLRSKNEN 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	248/708 (35%)
		Myosin_TH1	801..977	CDD:461801	38/233 (16%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	317/1113 (28%)
		Smc	1607..>1901	CDD:440809