DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYO5

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_013827.1	Gene:	MYO5 / 855136	SGDID:	S000004715	Length:	1219	Species:	Saccharomyces cerevisiae

Alignment Length:	1041	Identity:	366/1041 - (35%)
Similarity:	565/1041 - (54%)	Gaps:	186/1041 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QREAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRE 68
            ::|.||.|..||.::|.|...:||:|||.|.:||||||.|.:|:||:|.:.||....:.:|||:.
Yeast    33 KKEVGVSDLTLLSKISDEAINENLKKRFLNATIYTYIGHVLISVNPFRDLGIYTDAVMNEYKGKN 97

  Fly    69 LFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVK 133
            ..|..||:||||:|.|..:|...::.|::||||||||||||:|.||:||||.::...:: |.::|
Yeast    98 RLEVPPHVFAIAESMYYNMKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASSTHTES-IGKIK 161

  Fly   134 NVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERN 198
            ::::.:|.:||:||.|||.||:||||.|||::|:|:.:.:|..|.||||||||.|||.|...|||
Yeast   162 DMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNITNYLLEKQRVVSQIKNERN 226

  Fly   199 FHSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEV 260
            ||.|||..:||:|...:.:.:||.. :|.|....   |.:.:.:..||:.|..|.:.:|...:|.
Yeast   227 FHIFYQFTKGASDAYRQTFGVQKPE-QYVYTAAAGCISAETIDDLQDYQETLKAMRVIGLGQEEQ 290

  Fly   261 QTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKST------AKLLQVTETELSTALTKRVIAAG 319
            ..|:|.:||:|.:|||.|  ||:|   .....::.|      |.|||:....|..:|.:|::...
Yeast   291 DQIFRMLAAILWIGNVSF--IENE---EGNAQVRDTSVTDFVAYLLQIDSQLLIKSLVERIMETN 350

  Fly   320 -----GNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAI-LFRGSKTQARFNSVIGVLD 378
                 |:|.....|..||:..:||||||||:.||.||:||:|::: .|.|::..      ||:||
Yeast   351 HGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSLQAFPGAEKS------IGILD 409

  Fly   379 IYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVE-- 441
            |||||||:.|||||.||||.||||||:||:|.||.|||.|:||.|:||.|:||:||::|||:|
Yeast   410 IYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIKYFDNKVVCDLIEAR 474

  Fly   442 QPHKGIIAIMDEACLSVGKVTDDTLLGAMDK------NL-SKHPHYTSRQLKPTDKELKHREDFR 499
            :| .||.|.|::   ||.....|:  .|.|:      || :.:||:..|..|           |.
Yeast   475 RP-PGIFAAMND---SVATAHADS--NAADQAFAQRLNLFTTNPHFDLRSNK-----------FV 522

  Fly   500 ITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQ 564
            |.||||||.|:|:|..:||||.|.:|...|:..:.:..|:.::|:...  :::.:||.|||....
Yeast   523 IKHYAGDVTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPDTVD--RESKRRPPTAGDKII 585

  Fly   565 RSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDK 629
            :|..|||.||.|.:|.|:|.||||:.||...:|:.:|.||::||||.||:|:|||||.:||.::|
Yeast   586 KSANDLVETLSKAQPSYIRTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRRAGFAYRQVFEK 650

  Fly   630 FLLRYKMIS-------QYTWPNFRAGSDRDGVRVLIEEKKF-AQDVKYGHTKIFIRSPRTLFALE 686
            |:.|:.::|       .|||    .|...|.|:.::::... .|:.:.|.|.:||::|.||||||
Yeast   651 FVERFYLLSPHCSYAGDYTW----QGDTLDAVKYILQDSSIPQQEYQLGVTSVFIKTPETLFALE 711

  Fly   687 HQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDY 751
            |.|:....::...:|:..|.::.||    :.||..|.|..:..|          ...|.:::|||
Yeast   712 HMRDRYWHNMAARIQRAWRRFLQRR----IDAATKIQRTIRERK----------EGNKYEKLRDY 762

  Fly   752 GKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQAR 816
            |..:      |.|||.           |.:|.|..|                            |
Yeast   763 GTKV------LGGRKE-----------RRSMSLLGY----------------------------R 782

  Fly   817 RWVGDYLA--NSQENSGYEAYNGSIKNIRNHPADGETFQQVLFS----SFVKKFNHFNKQANRAF 875
            .::||||:  .|:....|.....|||            ::|:||    :...||....::..:.|
Yeast   783 AFMGDYLSCNESKSKGAYIKRQVSIK------------EKVIFSIHGEALHTKFGRSAQRLKKTF 835

  Fly   876 IVSDSTIHKLDG--IKNKF---KDMKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEY 935
            :::.:|::.:..  ::|..   :|.|  |.:|.:.::|::                   :|:.::
Yeast   836 LLTPTTLYIVGQTLVQNAMTYTQDYK--IDVRNIQAVSLT-------------------NLQDDW 879

  Fly   936 TPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGKARIITVEAASNVEVPNFRPKEGN 1000
            ..:|....|:.        ..|..|..:..:.|::. ||:.|   |.::..|.:|   ::.|.|.
Yeast   880 VAIKLASSGQP--------DPLINTYFKTELITHLK-RLNDK---IQIKIGSAIE---YQKKPGK 929

  Fly  1001 I 1001
            :
Yeast   930 L 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	306/715 (43%)
		MYSc_Myo1	21..677	CDD:276829	290/687 (42%)
		Myosin_TH1	801..983	CDD:283635	33/192 (17%)
MYO5	NP_013827.1	COG5022	1..1186	CDD:227355	366/1041 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	529	1.000	Domainoid score	I38
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	562	1.000	Inparanoid score	I159
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		mtm9169
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2201
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890