Protein Alignment Myo31DF and MYO2

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_014971.1
• Gene: MYO2 / 854504
• SGDID: S000005853
• Length: 1574
• Species: Saccharomyces cerevisiae
• Alignment Length: 1045
• Identity: 317/1045 - (30%)
• Similarity: 521/1045 - (49%)
• Gaps: 179/1045 - (17%)

  Fly    10 QDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMN-IYGPETIRKYKGRELFENA 73
            :|...|..::....:..:::|:...:||||.|.|.::.||:.::: :|..:.|:.|.|:...|..
Yeast    73 EDLTSLSYLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRRGELE 137

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAV-----TNAQGQNEIERVK 133
            |||||||:.|||::|..:|:..|::|||||||||.::|.||:|.|:|     ...|.|.|:...:
Yeast   138 PHLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSATVQHQVEMSETE 202

  Fly   134 NVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERN 198
            ..::.:|.|:|.||||||.|||||||||||::|.||.....:|..|..||||:||:|.|.|.|||
Yeast   203 QKILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIERN 267

  Fly   199 FHSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEV 260
            :|.||||:.|.......:..| .:...|.|:|||   .::.:.:..:||.|.:|...:|.:.:..
Yeast   268 YHIFYQLMAGLPAQTKEELHL-TDASDYFYMNQGGDTKINGIDDAKEYKITVDALTLVGITKETQ 331

  Fly   261 QTIWRTIAAVLHLGNVEF-QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQ 324
            ..|::.:||:||:||:|. :|..|..:.:::.:||...:||.:.....:..:||:.|......:.
Yeast   332 HQIFKILAALLHIGNIEIKKTRNDASLSADEPNLKLACELLGIDAYNFAKWVTKKQIITRSEKIV 396

  Fly   325 KDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNS 389
            .:.|.:||...||::||.||..||.|::..||..:.  ......:.:|.||||||||||.|:.||
Yeast   397 SNLNYSQALVAKDSVAKFIYSALFDWLVENINTVLC--NPAVNDQISSFIGVLDIYGFEHFEKNS 459

  Fly   390 FEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMD-E 453
            ||||||||.||||||.|.:.|.|.|||||.:|.|||:.||:.:|:...||:|. ..||::::| |
Yeast   460 FEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCIDLIEN-KLGILSLLDEE 523

  Fly   454 ACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQL-KPTDKELKHREDFRITHYAGDVIYNINGFIEK 517
            :.|..|  :|::....:.:.|.|.|  |::.. ||...:.|    |.::|||.||.|::.|||||
Yeast   524 SRLPAG--SDESWTQKLYQTLDKSP--TNKVFSKPRFGQTK----FIVSHYALDVAYDVEGFIEK 580

  Fly   518 NKDTLYQDFKRLLHNSKD---ANLSEMWPEGAQDIK------------------KTTKRPLTAGT 561
            |:||:......:|..|.:   .|:.|...:.|:.::                  :|..|..|.|:
Yeast   581 NRDTVSDGHLEVLKASTNETLINILEGLEKAAKKLEEAKKLELEQAGSKKPGPIRTVNRKPTLGS 645

  Fly   562 LFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQR 626
            :|::|:.:|:.|:......|:||||||..|.:..||...|..|:|..|:||.:|:..|||..|..
Yeast   646 MFKQSLIELMNTINSTNVHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRWT 710

  Fly   627 YDKFLLRYK-MISQYTWP---NFRAGSDRDGVRV--LIEEKKFAQDVKY--GHTKIFIRSPRTLF 683
            :::|:|||. :|....|.   ..:..::.|.:.|  :|.:.......||  |:||||.::....:
Yeast   711 FEEFVLRYYILIPHEQWDLIFKKKETTEEDIISVVKMILDATVKDKSKYQIGNTKIFFKAGMLAY 775

  Fly   684 ALEHQRNEMIPHIVTLLQKRVR-----------------------GWIVRRNFK---KMKAAITI 722
             ||..|:..:.:.:.::||::|                       |:|:|:...   |:..|..:
Yeast   776 -LEKLRSNKMHNSIVMIQKKIRAKYYRKQYLQISQAIKYLQNNIKGFIIRQRVNDEMKVNCATLL 839

  Fly   723 VRAYKAYKLRSYV-------QELANRLRK------AKQMRDYGKSIQWPQPPLAGRKVEAKLHRM 774
            ..||:.:.:|:.|       ..|..::||      .||..:|..::          .:::|: |.
Yeast   840 QAAYRGHSIRANVFSVLRTITNLQKKIRKELKQRQLKQEHEYNAAV----------TIQSKV-RT 893

  Fly   775 FDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSI 839
            |:           |||.:.:.:...:...:|..||                        |....:
Yeast   894 FE-----------PRSRFLRTKKDTVVVQSLIRRR------------------------AAQRKL 923

  Fly   840 KNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKR-TIKIRE 903
            |.::   ||            .|..||..:.   ::.:.:..|.....:.:|.|:.|. |.:|:|
Yeast   924 KQLK---AD------------AKSVNHLKEV---SYKLENKVIELTQNLASKVKENKEMTERIKE 970

  Fly   904 LTSISVSPG-----------RDQLIVFHSSKNKDLVF------SLESEYTPLKEDRIGEVVGIVC 951
            | .:.|...           ::.||...:.|:||:..      :|:|....||:.:: |:..:|
Yeast   971 L-QVQVEESAKLQETLENMKKEHLIDIDNQKSKDMELQKTIENNLQSTEQTLKDAQL-ELEDMV- 1032

  Fly   952 KKYHD 956
             |.||
Yeast  1033 -KQHD 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	255/696 (37%)
		Myosin_TH1	801..977	CDD:461801	33/174 (19%)
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	317/1045 (30%)