Protein Alignment Myo31DF and MYO3

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_012793.2
• Gene: MYO3 / 853729
• SGDID: S000001612
• Length: 1272
• Species: Saccharomyces cerevisiae
• Alignment Length: 1047
• Identity: 376/1047 - (35%)
• Similarity: 571/1047 - (54%)
• Gaps: 181/1047 - (17%)

  Fly     4 QREAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRE 68
            ::|.|:.|..||.::|.|...:||:|||:||.||||||.|.:|:||:|.:.||....:..|||:.
Yeast    33 KKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKN 97

  Fly    69 LFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVK 133
            ..|..||:||||:|.|..||...::.|::||||||||||||:|.||:||||.:|:..:: |.::|
Yeast    98 RLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSES-IGKIK 161

  Fly   134 NVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERN 198
            ::::.:|.:||:||.|||.||:||||.|||::|:|:.:.:|..|.||||||||.|||.|...|||
Yeast   162 DMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERN 226

  Fly   199 FHSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEV 260
            ||.|||..:||:|...:.:.:|... :|.|....   :.|.:.:..||:||..|.:|:|...:|.
Yeast   227 FHIFYQFTKGASDTYKQMFGVQMPE-QYIYTAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQ 290

  Fly   261 QTIWRTIAAVLHLGNVEFQTIEDE---LVISNKQHLKSTAKLLQVTETELSTALTKRVIAAG--- 319
            ..|:|.:||:|.:||:.|  ||:|   ..:.:.......|.||||..:.|...|.:|::...
Yeast   291 DQIFRMLAAILWIGNISF--IENEEGNAQVGDTSVTDFVAYLLQVDASLLVKCLVERIMQTSHGM 353

  Fly   320 --GNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAI-LFRGSKTQARFNSVIGVLDIYG 381
              |:|.....|..||...:||||||||:.||.||:.|:|.:: .|.|:      :..||:|||||
Yeast   354 KRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGA------DKSIGILDIYG 412

  Fly   382 FEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPH-K 445
            ||||:.|||||.||||.||||||:||:|.||.|||.|:||.|:||.|:||:||::|||:|..: .
Yeast   413 FEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPP 477

  Fly   446 GIIAIMDEACLSVGKVTDDTLLGAMDK------NL-SKHPHYTSRQLKPTDKELKHREDFRITHY 503
            ||:|.|::   |:.....|:  .|.|:      || :.:|::..|..|           |.|.||
Yeast   478 GILAAMND---SIATAHADS--NAADQAFAQRLNLFNSNPYFELRANK-----------FVIKHY 526

  Fly   504 AGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTK-RPLTAGTLFQRSM 567
            ||||.|:|||..:||||.|.:|...|:..:.:..||.::|:   |:.|.:| ||.|||....:|.
Yeast   527 AGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPD---DVDKDSKRRPPTAGDKIIKSA 588

  Fly   568 ADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLL 632
            .:||.||.|.||.|:|.||||..||...:|:.:|.|||:||||.||:|:|||||.:||.::||:.
Yeast   589 NELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVE 653

  Fly   633 RYKMIS-------QYTWPNFRAGSDRDGVRV-----LIEEKKFAQDVKYGHTKIFIRSPRTLFAL 685
            |:.::|       .|||.    |...:.|::     :|.||:|    :.|.|.:||::|.:||||
Yeast   654 RFYLLSPDCSYAGDYTWD----GDTLEAVKLILRDAMIPEKEF----QLGVTSVFIKTPESLFAL 710

  Fly   686 EHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYK-LRSYVQELANRLRKAKQMR 749
            |..|::...::...:|:..|.::.||    :.|||.|.|..:..| ...||           ::|
Yeast   711 EDMRDKYWYNMAARIQRAWRRFLQRR----IDAAIKIQRTIREKKGGNKYV-----------KLR 760

  Fly   750 DYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQ 814
            |||..:      |||:|.           |.:|.|..|
Yeast   761 DYGTKL------LAGKKE-----------RRSMSLLGY--------------------------- 781

  Fly   815 ARRWVGDYLA--NSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVK------KFNHFNKQA 871
             |.::||||:  .|:....|......||:            :|:||  :|      ||....::.
Yeast   782 -RAFMGDYLSCNESKTKGSYIRRQVGIKD------------KVVFS--IKGECLHSKFGRSAQRL 831

  Fly   872 NRAFIVSDSTIHKLDGIKNKFKDMKRT----IKIRELTSISVSPGRDQ---LIVFHSSKNKDLVF 929
            .:.||::..|.: :.|...:...||.|    |.:.::..:|::..:|.   :|:.:|:::..|:
Yeast   832 KKVFILTKKTFY-IIGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGVILVNSTQSDPLI- 894

  Fly   930 SLESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGKARIITVEAASNVEVPNF 994
                 .||.|.:.:..:     ||.::    ::.:.|...|....... ::.||.:    ::.:.
Yeast   895 -----NTPFKTELMTRL-----KKLNE----KIMIKVGPTIEYHKQPN-KLHTVRS----KISDS 940

  Fly   995 RPKEGNI 1001
            .||.|:|
Yeast   941 APKYGDI 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	297/688 (43%)
		Myosin_TH1	801..977	CDD:461801	35/190 (18%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	376/1047 (36%)