DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYO4

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_009373.1	Gene:	MYO4 / 851204	SGDID:	S000000027	Length:	1471	Species:	Saccharomyces cerevisiae

Alignment Length:	1109	Identity:	341/1109 - (30%)
Similarity:	541/1109 - (48%)	Gaps:	162/1109 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQM-NIYGPETIRKYKGRELFENAP 74
            |...|..::....:..::||:.||.||||.|.|.::.||:.:: ::|..|.|:.|..:...|..|
Yeast    75 DLTTLSYLNEPAVLHAIKKRYMNGQIYTYSGIVLIAANPFDKVDHLYSREMIQNYSSKRKDELEP 139

  Fly    75 HLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAV---TNAQGQNEIERVKNVL 136
            ||||||:.|||.:...:.:..:::|||||||||.::|.||:|.|:|   .|.:|:.|:.::::.:
Yeast   140 HLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNREGEVEMSQIESQI 204

  Fly   137 IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHS 201
            :.:|.|:|.||||||.|||||||||||:.|.||......|..|..|||||||:|.|...|||:|.
Yeast   205 LATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQPETERNYHI 269

  Fly   202 FYQLLRGANDNELRQYELQKETGK-YHYLNQGSMDILT---EKSDYKGTCNAFKTLGFSTDEVQT 262
            |||:|.|..: .::| ||...:.| |||.|||....:.   |..:||.|.:|...:|.:.:....
Yeast   270 FYQILEGLPE-PVKQ-ELHLSSPKDYHYTNQGGQPNIAGIDEAREYKITTDALSLVGINHETQLG 332

  Fly   263 IWRTIAAVLHLGNVEFQ-TIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQKD 326
            |::.:|.:||:||:|.: |..|..:.|.:|:|:...:||.:.....:..:.|:.|......:..:
Yeast   333 IFKILAGLLHIGNIEMKMTRNDASLSSEEQNLQIACELLGIDPFNFAKWIVKKQIVTRSEKIVTN 397

  Fly   327 HNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFE 391
            .|..||...:|::||.||..||.|::..||:.:.......|....|.||:|||||||.|:.||||
Yeast   398 LNYNQALIARDSVAKFIYSTLFDWLVDNINKTLYDPELDQQDHVFSFIGILDIYGFEHFEKNSFE 462

  Fly   392 QFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMD-EAC 455
            ||||||.||||||.|.:.|.|.|||||.:|.|||:.||:.:|:...||:|. ..||::::| |:.
Yeast   463 QFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFSDNQPCIDLIEN-KLGILSLLDEESR 526

  Fly   456 LSVGKVTDDTLLGAMDKNLSKHPHYTSRQL--KPTDKELKHREDFRITHYAGDVIYNINGFIEKN 518
            |..|  :|::....:....:|.|   |.::  ||...:.|    |.::|||.||.|.:.||||||
Yeast   527 LPSG--SDESWASKLYSAFNKPP---SNEVFSKPRFGQTK----FIVSHYAVDVEYEVEGFIEKN 582

  Fly   519 KDTL---YQD---------FKRLLHN----SKDANLSEMWPEGAQDIKK-------TTKRPLTAG 560
            :|::   :.|         ||::|.|    |.||      ||.....||       :.|:| |.|
Yeast   583 RDSVSLGHLDVFKATTNPIFKQILDNRELRSDDA------PEEQNTEKKIMIPARLSQKKP-TLG 640

  Fly   561 TLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQ 625
            ::|::|:.:|:..:......|:||||||..|....||...|..|:|..|:||.:|:..|||..|.
Yeast   641 SMFKKSLGELMAIINSTNVHYIRCIKPNSEKKPWEFDNLMVLSQLRACGVLETIRISCAGFPSRW 705

  Fly   626 RYDKFLLRYKMISQYT-WPNFRAGSDRDGVRVL-----IEEKKFAQDVKY--GHTKIFIRSPRTL 682
            .:|:|:.||.:::.|: |.......|.....::     |.:...:...||  |:||||.::....
Yeast   706 TFDEFVQRYFLLTDYSLWSGILYNPDLPKEAIVNFCQSILDATISDSAKYQIGNTKIFFKAGMLA 770

  Fly   683 FALEHQRNEMIPHIVTLLQKRVRGWIVR-------RNFKKMKAAI--TIVRAYKAYKLRSYVQEL 738
            | ||..|...:..|..::||::|....|       .:.||.::.|  .:||....::|::....|
Yeast   771 F-LEKLRTNKMNEICIIIQKKIRARYYRLQYLQTMESIKKCQSQIRSLLVRTRVDHELKTRAAIL 834

  Fly   739 ANRLRKAKQMRDY-----GKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRS-----EWP 793
            .....:|...|:|     |:.|:. |.....:.:...::|.| ...|.:|:..|.||     ::.
Yeast   835 LQTNIRALWKREYYRAAIGQIIKL-QCTCKRKLILDSVNRKF-MLMAAVIIQSYIRSYGHKTDYR 897

  Fly   794 QL-RLQIIAATAL---AGRRPY---------------WG-----QARRWVGDYLAN--------- 825
            .| |..|:..:|:   ..||.|               :|     :|..:...::.|
Yeast   898 TLKRSSILVQSAMRMQLARRRYIVLQKEVEERNIRASYGIGLLEEAIEFKNSFILNLEMLNDSYT 962

  Fly   826 --------------SQENSGYE----AYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQAN 872
                          |::...||    .||..|..::       |.|..:.::..|| |...::..
Yeast   963 RLTQLLQGDLSNIPSKQRQEYETIVNGYNDKISKLK-------TLQVEIMNTLNKK-NALKERKK 1019

  Fly   873 RAFIVSDSTIHKLDGIK----NKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLES 933
            :...:..|.:..|..||    ::..|..:::| :||..|.....:|....:.::|| |.|..|..
Yeast  1020 KQSSLIQSHMQSLAAIKGNKPSRLSDEVKSMK-QELAFIENVIAQDFTTTYSANKN-DKVKGLGI 1082

  Fly   934 EYTPLK-------------EDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGKARIITVEA 985
            ....:|             .|.:..::.:.|.......|...:||||......:.|...:||...
Yeast  1083 AGQQVKPKLVNVIRRESGNPDLLELLMDLNCYTLEVTEGYLKKVNVTEVNGDNVLGPIHVITTVV 1147

  Fly   986 ASNV 989
            :|.|
Yeast  1148 SSLV 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	266/721 (37%)
		MYSc_Myo1	21..677	CDD:276829	261/698 (37%)
		Myosin_TH1	801..983	CDD:283635	43/248 (17%)
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	341/1109 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910