DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and ATM1

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001154628.2	Gene:	ATM1 / 821534	AraportID:	AT3G19960	Length:	1176	Species:	Arabidopsis thaliana

Alignment Length:	992	Identity:	285/992 - (28%)
Similarity:	467/992 - (47%)	Gaps:	186/992 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFEN 72
            ||.|.:.|..::....:.||..|:....|||..|.|.|::||::::.:||...|..|  |:....
plant   166 GVDDLMQLSYLNEPSVLYNLNYRYNQDMIYTKAGPVLVAVNPFKEVPLYGNRYIEAY--RKKSNE 228

  Fly    73 APHLFAIADSAYRVLKQRQQDTCILI----------------SGESGAGKTEASKIIMKYIAAVT 121
            :||::||||:|.|.:.:.:.:..|:|                ||||||||||.:||.|:|:||:.
plant   229 SPHVYAIADTAIREMIRDEVNQSIIIRCICIHESMTYSISSSSGESGAGKTETAKIAMQYLAALG 293

  Fly   122 NAQGQNEIERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEK 186
            ...|      ::..::::|.|||.||||||.||||||||||.::|.|.......|..|..:||||
plant   294 GGSG------IEYEILKTNPILEAFGNAKTLRNDNSSRFGKLIEIHFSESGKISGAQIQTFLLEK 352

  Fly   187 SRVVQQQPGERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCN 248
            |||||...|||::|.||||..||:. .||:........:|.||.|.   |::.:.:...:.....
plant   353 SRVVQCAEGERSYHIFYQLCAGASP-ALREKLNLTSAHEYKYLGQSNCYSINGVDDAERFHTVKE 416

  Fly   249 AFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQTIEDELVISN----------------KQH----- 292
            |...:..|.::.::::..:||||.||||.|..|::|..:..                ||.
plant   417 ALDIVHVSKEDQESVFAMLAAVLWLGNVSFTVIDNENHVEPVADESFLFHSLGSWCWKQECLLHN 481

  Fly   293 --LKSTAKLLQVTETELSTALTKRVIAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRI 355
              |.:.|||:.....||:..|:||.:....:.:.:.....||...:|||||:||..||.|::.:|
plant   482 MCLSTVAKLIGCNINELTLTLSKRNMRVRNDTIVQKLTLPQAIDARDALAKSIYSCLFDWLVEQI 546

  Fly   356 NRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQR 420
            |:::.. |.:...|   .|.:|||||||.||.||||||||||.||:|||.|...:.|.|||||.:
plant   547 NKSLAV-GKRRTGR---SISILDIYGFESFDKNSFEQFCINYANERLQQHFNRHLFKLEQEEYIQ 607

  Fly   421 EGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQL 485
            :||:||.:::.:|:....|.|:...|:::::||.. :....||.||...:.::|..:..:...:.
plant   608 DGIDWTRVDFEDNQNCLSLFEKKPLGLLSLLDEES-TFPNGTDLTLANKLKQHLQSNSCFRGDKG 671

  Fly   486 KPTDKELKHREDFRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHN----------------SK 534
            |.          |.:.||||:|.|...||:|||:|.|:.|..:||.:                |:
plant   672 KL----------FTVVHYAGEVTYETTGFLEKNRDLLHSDSIQLLSSCSCLLPQAFASSMLIQSE 726

  Fly   535 DANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEE 599
            ...:..::..|..|.::     |:..|.|:..:..|:..|....|.::||||||:::|..|:::.
plant   727 KPVVGPLYKAGGADSQR-----LSVATKFKSQLFQLMQRLGNTTPHFIRCIKPNNIQSPGVYEQG 786

  Fly   600 RVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFA 664
            .|..|:|..|:||.|        .:..|.:|.:                     :.:|.:.....
plant   787 LVLQQLRCCGVLEVL--------CKGPYKRFFI---------------------IAILHQFNILP 822

  Fly   665 QDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAY-KA 728
            :..:.|:||:|.|:.: :..||..||..: |.:..:|...||:..|...|::|..|:|:::: :.
plant   823 EMYQVGYTKLFFRTGQ-IGVLEDTRNRTL-HGILRVQSSFRGYQARCLLKELKRGISILQSFVRG 885

  Fly   729 YKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWP 793
            .|:|....||..|.:.|..::...||                               |..|.::.
plant   886 EKIRKEFAELRRRHKAAATIQSQVKS-------------------------------KIARIQYK 919

  Fly   794 QLR-LQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLF 857
            .:. ..::..:|:.|    | ..||..||.        |:....|:..|        |..:.::.
plant   920 GIADASVVIQSAIRG----W-LVRRCSGDI--------GWLKSGGAKTN--------ELGEVLVK 963

  Fly   858 SSFVKKFNHFNKQANRAF----IVSDSTIHKLDGIKNKFKDMKRTIK---------IRELTSISV 909
            :|.:.:......:|..|.    ..:|....:|...:|::.:.:..:|         :|.|.| |:
plant   964 ASVLSELQRRVLKAEAALREKEEENDILQQRLQQYENRWSEYETKMKSMEEIWQKQMRSLQS-SL 1027

  Fly   910 SPGRDQLIVFHSSKNKD 926
            |..:..|.|..|::|.|
plant  1028 SIAKKSLAVEDSARNSD 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	236/739 (32%)
		MYSc_Myo1	21..677	CDD:276829	229/713 (32%)
		Myosin_TH1	801..983	CDD:283635	28/139 (20%)
ATM1	NP_001154628.2	MYSc	160..847	CDD:214580	236/739 (32%)
ATM1	NP_001154628.2	MYSc_Myo8	179..835	CDD:276834	229/713 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910