Protein Alignment Myo31DF and Myo3a

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_680779.4
• Gene: Myo3a / 667663
• MGIID: 2183924
• Length: 1613
• Species: Mus musculus
• Alignment Length: 1034
• Identity: 298/1034 - (28%)
• Similarity: 489/1034 - (47%)
• Gaps: 176/1034 - (17%)

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            |.|...||.:......::|.|.:....||.|:|::.:::||::.:.||..:..|.|.|.:...|.
Mouse   340 VDDLATLDVLDENTVSEHLEKCYSRDQIYIYVGDILIALNPFQSLGIYSTKLSRLYIGAKRTANP 404

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLIQ 138
            ||:||:||..|:.:.....|.||:|||||||||||::.::::.:..:..|..:...|::    :|
Mouse   405 PHIFAMADLGYQSMVTYNADQCIVISGESGAGKTESAHLLVQQLTVLGKANNRTLQEKI----LQ 465

  Fly   139 SNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSFY 203
            .|.::|.||||.|..||||||||||::::|......||..|:.||||||||:.|..||:|||.||
Mouse   466 MNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHIFY 530

  Fly   204 QLLRG-ANDNELRQYELQKETGKYHYLNQGSM----DILTE---KSDYKGTCNAFKTLGFSTDEV 260
            .:..| |...:|..|:| .|.....||...::    |::..   ||.|:.....||.:||:.:::
Mouse   531 YIYAGLAEKKKLALYKL-PENKPPRYLQNDNLRTVQDMMNNSFYKSQYELIEQCFKVIGFTMEQL 594

  Fly   261 QTIWRTIAAVLHLGNVEFQTIE-----DELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGG 320
            .:::..:||:|::||:||.::.     |:..|.|...|:::|.||.:...||..|||...:...|
Mouse   595 GSVYSVLAAILNVGNIEFSSVATEYQMDKSYICNHTALENSASLLCIQADELQEALTSHCVVTRG 659

  Fly   321 NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIF 385
            ..:.:.:...:|...:||:||.:|.|||:||::.|| ::|...:.........||:|||:|||.|
Mouse   660 ETIIRPNTVEKAADVRDAMAKTLYGRLFSWIVNCIN-SLLKHDTSPSGDEELNIGILDIFGFENF 723

  Fly   386 DSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAI 450
            ..|||||.|||..||::|..|.:.|...||.||..|.::...|||.:|:.:.|:..|...|::::
Mouse   724 KRNSFEQLCINIANEQIQYYFNQHVFAWEQNEYLNEDVDARVIEYEDNRPLLDMFLQKPMGLLSL 788

  Fly   451 MDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFI 515
            :||.. ...|.||.||:...:.||.....:     :|...||    .|.|.||||.|:|:.:||:
Mouse   789 LDEES-RFPKATDQTLIEKFEDNLKSQYFW-----RPKRMEL----SFGIHHYAGKVLYSASGFL 843

  Fly   516 EKNKDTLYQDFKRLLHNS--------------KDANLS----------EMW-PEGAQDIKK---- 551
            .||:||...|...||.:|              |..||.          :|| .|.:.::.|
Mouse   844 AKNRDTFPTDIVLLLRSSENSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMWNSEKSTNLTKGETR 908

  Fly   552 ---------TTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRY 607
                     |..:..|..:.|:.|:.||:..::..:|.:|||||||:.:.:..:|:|:|..|:|.
Mouse   909 DVTCHACETTNVKTQTVSSYFRYSLMDLLSKMVVGQPHFVRCIKPNNERQARKYDKEKVLLQLRC 973

  Fly   608 LGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVR----VLIEEKKFAQDVK 668
            .|:||..|:||.|:.||..:..|:.||.::..       ..|:...|.    ..|.||....:..
Mouse   974 TGILETARIRRLGYSHRILFANFIKRYYILCY-------KSSEEPPVSPDTCAAILEKAGLDNWA 1031

  Fly   669 YGHTKIFIRSPRTLFALEH---QRNEMIPHIVTLLQKRVRGWIVRRNF-----KKMKAAITIVRA 725
            .|.||:|::    .:.:|.   .|.|....:| |:|..||.::..|.:     |:..:|:.|..|
Mouse  1032 LGKTKVFLK----YYHVEQLNLMRKEATNKLV-LIQASVRAFLGARRYQELQQKRKSSAVIIQSA 1091

  Fly   726 YKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRS 790
            .:.:.||.:.:|.:| ::.|                 |||.:.|| .:.||: :.|.
Mouse  1092 ARRHLLRKHGKETSN-VKSA-----------------AGRSIRAK-DQEFDY-KKNF-------- 1128

  Fly   791 EWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENS-GYEAYNGSIKNIRNHPADGETFQQ 854
                                   :.:|  ..::....||: .....|.|..|.:..|:.|:|
Mouse  1129 -----------------------ETKR--ESFVKKQTENAVPTNESNTSTPNNKESPSAGKT--- 1165

  Fly   855 VLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKD-MKRTIKIRELTSISVSPGRDQLIV 918
               :.|..:....|.::|      :...|....:.|.:.: ..:.:.|.|.|...|||
Mouse  1166 ---APFRAESKATNVESN------NRRYHTQKKMSNVYAEGQNQELYIVEDTWAEVSP------- 1214

  Fly   919 FHSSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGK 977
                 .:..|..||......||::...|:...|:.|.:.:..|     .:..:| |:|:
Mouse  1215 -----RQKYVQDLEESRKMRKEEKGDAVIQSYCQWYTEGSNFE-----ESKATC-LEGR 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	236/710 (33%)
		Myosin_TH1	801..977	CDD:461801	31/177 (18%)
Myo3a	NP_680779.4	Protein Kinases, catalytic domain	2..287	CDD:473864
		MYSc_Myo3	352..1040	CDD:276830	236/710 (33%)
		MBD_Myo3a	1407..1454	CDD:439318