DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYO1G

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_149043.2	Gene:	MYO1G / 64005	HGNCID:	13880	Length:	1018	Species:	Homo sapiens

Alignment Length:	1023	Identity:	502/1023 - (49%)
Similarity:	686/1023 - (67%)	Gaps:	34/1023 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELF 70
            |.|..||||||||:||.||.||:.||:.|.||||||||.||:|||:::.:||||.|.:|:||||:
Human     8 EYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELY 72

  Fly    71 ENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNV 135
            |..|||:|:|::||:.:|.|.:||||:||||||||||||||.||:|||||||...:.|:||||:|
Human    73 ERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDV 137

  Fly   136 LIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFH 200
            |::|..:||.||||:||||.|||||||||||.||:|.||:||.|.:||||||||::|..||||||
Human   138 LLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFH 202

  Fly   201 SFYQLLRGANDNELRQYELQKETGKYHYLNQG---------SMDILTEKSDYKGTCNAFKTLGFS 256
            :|||||||:.|.:|.:..|::....|::.:||         ::|  :::..::....|.:.:|||
Human   203 AFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALD--SDEQSHQAVTEAMRVIGFS 265

  Fly   257 TDEVQTIWRTIAAVLHLGNVEFQTIE------DELVISNKQHLKSTAKLLQVTETELSTALTKRV 315
            .:||:::.|.:||:|||||:||...|      :.|.::.:..:...|:|.......:..:|..|.
Human   266 PEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLART 330

  Fly   316 IAAGG-NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRG-SKTQARFNSVIGVLD 378
            :|:|| .:::|.|.|.:|.|.:||.|||:|.|||.|:::|||..:..|| ...:...::||||||
Human   331 VASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVLD 395

  Fly   379 IYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQP 443
            |||||:|..||||||||||||||||||||:|:||||||||:||||.|.::|||||..|.||||:|
Human   396 IYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVERP 460

  Fly   444 HKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVI 508
            |:||:|::||||.|.|.:||...|..:|.:...|.|||||||.||||.::...||||.||||||.
Human   461 HRGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHYAGDVT 525

  Fly   509 YNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVT 573
            |::.|||:||:|.|:|||||||:||.|..|..|||:|.|||.:.|||||||||||:.||..||..
Human   526 YSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVEN 590

  Fly   574 LLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMIS 638
            |..||||||||||||:.|.:...||....|||.|||||||:|||||||..||.|.:|||||||..
Human   591 LASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYKMTC 655

  Fly   639 QYTWPNFRAGSDRDGVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKR 703
            :|||||...|||:..|..|:|:.....||.:||:|:||||||||..||..|..:||.||.||||.
Human   656 EYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKA 720

  Fly   704 VRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVE 768
            .||.:.|...::::|..||:|.::.:|:|:::.||..|.:.|:|...||:.:.||.||...:..:
Human   721 WRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPAVLQPFQ 785

  Fly   769 AKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQEN-SGY 832
            ...|.:|..|||..::...|.|:.||::.::.|..||.|.|..||..|.|..|||:::.:| :..
Human   786 DTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSATDNPTAS 850

  Fly   833 EAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKR 897
            ..:...:|.::    |.:.|..|||||.|:|.|.|:|..|||.:::|..::|||. ..:::.| |
Human   851 SLFAQRLKTLQ----DKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDP-DRQYRVM-R 909

  Fly   898 TIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRIGEVVGIV---CKKYHDLTG 959
            .:.:..:|.:||:.|.|||:|.|:....|||..|.....|| ::|:||:||::   |:.    .|
Human   910 AVPLEAVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPL-DNRVGELVGVLAAHCQG----EG 969

  Fly   960 TELRVNVTTNISCRLDGKARIITVEAASNVEVPNFRPKEGNIIFEVPA 1007
            ..|.|.|:..|.....|..|:|:||.......|:||...|:.....|:
Human   970 RTLEVRVSDCIPLSHRGVRRLISVEPRPEQPEPDFRCARGSFTLLWPS 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	393/700 (56%)
		MYSc_Myo1	21..677	CDD:276829	373/672 (56%)
		Myosin_TH1	801..983	CDD:283635	64/185 (35%)
MYO1G	NP_149043.2	MYSc	4..706	CDD:214580	393/699 (56%)
		MYSc_Myo1	23..694	CDD:276829	373/672 (56%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	584..606		15/21 (71%)
		Myosin_TH1	815..980	CDD:283635	60/175 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143544
Domainoid	1	1.000	831	1.000	Domainoid score	I61
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1069	1.000	Inparanoid score	I247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53790
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		otm41967
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2270
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770