Protein Alignment Myo31DF and MYH7B

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: XP_047296292.1
• Gene: MYH7B / 57644
• HGNCID: 15906
• Length: 2033
• Species: Homo sapiens
• Alignment Length: 1084
• Identity: 309/1084 - (28%)
• Similarity: 505/1084 - (46%)
• Gaps: 208/1084 - (19%)

  Fly     3 MQREAGVQD-----FVLLDQVSM------EKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIY 56
            |.|||.:|.     |.||:.::|      ...:.|||:|:....||||.|..||::|||:.:.:|
Human   111 MVREAELQPMNPPRFDLLEDMAMMTHLNEASVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVY 175

  Fly    57 GPETIRKYKGRELFENAPHLFAIADSAYR-VLKQR-QQDTCILISGESGAGKTEASKII---MKY 116
            ....:..|||:...::.||::|:||:||. :|:.: :.|:......:.|.|:....:.:   .::
Human   176 TASVVAAYKGKRRSDSPPHIYAVADNAYNDMLRSKGRLDSSPTADPDLGPGRPLPRQPVHADHQF 240

  Fly   117 IAAVTNAQGQNEIERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITN 181
            :|..|....:::|       |::|..:|.||||||.||||||||||::.|.|..........|.:
Human   241 LATKTGGTLEDQI-------IEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDS 298

  Fly   182 YLLEKSRVVQQQPGERNFHSFYQLLRGANDNELRQYELQ------KETGKYHYLNQG--SMDILT 238
            ||||||||:.|.||||::|.:||:|.|      |:.|||      .....||:.:||  ::|.:.
Human   299 YLLEKSRVIFQLPGERSYHVYYQILSG------RKPELQDMLLLSMNPYDYHFCSQGVITVDNMN 357

  Fly   239 EKSDYKGTCNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEF--QTIEDELVISNKQHLKSTAKLLQ 301
            :..:...|.:|...||||.||....::.:.|:||.||::|  :..|::......:.....|.|:.
Human   358 DGEELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMG 422

  Fly   302 VTETELSTALTKRVIAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKT 366
            |:..:|...|....:..|...:.|..:..|..:...|||||.|||||.|::||||:.:   .:|.
Human   423 VSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTL---DTKL 484

  Fly   367 QARFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYF 431
            ..:|  .||||||.|||||:.|||||.|||:.||||||.|.:.:...|||||:||||:|..|::.
Human   485 PRQF--FIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFG 547

  Fly   432 NNKIIC-DLVEQ-----------PHK--------GIIAIMDEACLSVGKVTDDTLLGAM-DKNLS 475
            .:...| ||:|:           ||.        ||::|::|.|: ..|.:|.:....: |.:..
Human   548 LDLQPCIDLIEKVRRLRLSDVGGPHSYSFCSQPLGILSILEEECM-FPKASDASFRAKLYDNHAG 611

  Fly   476 KHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSE 540
            |.|::  :|.:| ||:.|::..|.:.||||.|.|:|.|::|||||.|.:....:...|::..|:.
Human   612 KSPNF--QQPRP-DKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLAT 673

  Fly   541 MW------------PEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSS 593
            ::            ..|.::.:|......|...|.:.::..|:..|...:|.:||||.||:.|:.
Human   674 LYENYAGSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTP 738

  Fly   594 TVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLI 658
            .|.|...|.||:|..|:||.:|:.|.||.:|..|..|..||::::....|:......|.....|:
Human   739 GVMDAFLVLHQLRCNGVLEGIRICRQGFPNRLLYTDFRQRYRILNPSAIPDDTFMDSRKATEKLL 803

  Fly   659 EEKKFAQ-DVKYGHTKI------------------FIR-----------SPRTLF------ALEH 687
            ....... ..::||||:                  |:|           .|:..|      .||.
Human   804 GSLDLDHTQYQFGHTKVGALWDQGWPWLWRSHWAGFMRMVGGYPGCLPLRPQVFFKAGLLGVLEE 868

  Fly   688 QRNEMIPHIVTLLQKRVRGWIVRRNFKKM----KAAITI---VRAYKAYKLRSYVQELANRLRKA 745
            .|::.:..::||||.|.||.::|..::::    .|..||   :||:.|.|..|:
Human   869 LRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSW----------- 922

  Fly   746 KQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRP 810
              |:.:.|.    :|.|...:.|.:|..:              |:|...||..:.||.|
Human   923 --MKLFFKM----KPLLRSAQAEEELAAL--------------RAELRGLRGALAAAEA------ 961

  Fly   811 YWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAF 875
               :.:.....:::.:||.:....   .::..:::.||.|....:|..|.|:
Human   962 ---KRQELEETHVSITQEKNDLAL---QLQAEQDNLADAEERCHLLIKSKVQ------------- 1007

  Fly   876 IVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKE 940
                        ::.|.|::...::..|..:..::..|.:               ||.|.|.||:
Human  1008 ------------LEGKVKELSERLEDEEEVNADLAARRRK---------------LEDECTELKK 1045

  Fly   941 DRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGKARIITVE 984
            | |.::...:.|...:...||.:|...|.....||.....:|.|
Human  1046 D-IDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKE 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	236/722 (33%)
		Myosin_TH1	801..977	CDD:461801	30/175 (17%)
MYH7B	XP_047296292.1	Myosin_N	72..117	CDD:460670	4/5 (80%)
		Motor_domain	140..820	CDD:473979	234/701 (33%)
		Myosin_tail_1	939..2016	CDD:460256	38/217 (18%)