DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and myo1f

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001243600.1	Gene:	myo1f / 565345	ZFINID:	ZDB-GENE-081104-506	Length:	1095	Species:	Danio rerio

Alignment Length:	1025	Identity:	359/1025 - (35%)
Similarity:	527/1025 - (51%)	Gaps:	189/1025 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            :::||.|.|||.:::.:..::||:|||.:..|:||||.|.:|:||::||..:....|..|:|...
Zfish    13 KQSGVDDMVLLSKITEDAIVENLKKRFLDDYIFTYIGPVLISVNPFKQMPYFTDREIELYQGAAQ 77

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            :||.||::|:.|:.||.:....::.|::||||||||||.|:|.||.||:.|:.  |.::::.||:
Zfish    78 YENPPHIYALTDNMYRNMMIDSENQCVIISGESGAGKTVAAKYIMGYISKVSG--GGSKVQHVKD 140

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
            :::|||.:||.||||||.||:||||||||.:|:|....:|.||.|:|:||||||||.|...||||
Zfish   141 IILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNENERNF 205

  Fly   200 HSFYQLLRGANDNELRQYELQKE------TGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGF 255
            |.||||:.|....       |||      ...|:||||.   .:|...:..|::.|..|.:.:|.
Zfish   206 HIFYQLIDGCTPQ-------QKEGLGIMTPDYYYYLNQSGTYKVDGTNDSKDFQETMEAMQVIGI 263

  Fly   256 STDEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKST------AKLLQVTETELSTALTKR 314
            .........:.:|.:||||::.|      :.:.|...::||      |.||.:.:..|...||.|
Zfish   264 PEMHQTLALQIVAGILHLGSINF------IEVGNYGQVESTDLLAFPAYLLGIDQNRLQEKLTSR 322

  Fly   315 VI----AAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSV-I 374
            ::    |.....:....|..||.:.:||||||:|.|||.:::..||:|:       |.....: :
Zfish   323 IMDSKWAGKTESINVTLNLEQARHTRDALAKALYTRLFDYLVEEINKAM-------QKPIEELSV 380

  Fly   375 GVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDL 439
            |||||||||||..|.|||||||:.||||||:||||.||.|||||.:|||:||.||||||||:|||
Zfish   381 GVLDIYGFEIFQRNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIKWTPIEYFNNKIVCDL 445

  Fly   440 VEQ--PHKGIIAIMDEACLSVGKVTDD---TLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFR 499
            :|.  ...||::::|:.|.::....|.   |||..:...:..|.|:.|           ....|.
Zfish   446 IENKLSPPGIMSVLDDVCATMHATKDGADMTLLQKLQNAVGTHDHFNS-----------WNSGFI 499

  Fly   500 ITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQ 564
            |.||||.|.|:||||.|:|:|.|:.|...|:.:|:...:..::||.....||  .||.|||:..:
Zfish   500 IHHYAGKVSYDINGFCERNRDVLFPDLIELMQSSQYDFIQSLFPENLNTDKK--GRPTTAGSKIK 562

  Fly   565 RSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDK 629
            |...:||.||:|..|.|:||||||:.|....::|.|..|||.||||.||:|||||||.:|:.:.|
Zfish   563 RQANELVSTLMKCTPHYIRCIKPNETKRPKDWEESRARHQVEYLGLRENIRVRRAGFAYRRIFPK 627

  Fly   630 FLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTLFALEHQRNEMI 693
            ||.||.:::..|||.:| |:::.||..|:.......| .:.|.:||||::|.:||.||..|....
Zfish   628 FLHRYAILTAETWPCWR-GAEQQGVLHLLRTVNMETDQYQMGRSKIFIKNPESLFLLEEMRERKF 691

  Fly   694 PHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWP 758
            ......:||..|.:|.||.:::|:                  :|.::.|..:|:.
Zfish   692 DTFARTIQKAWRKYIARRKYEQMR------------------EEASDILYNSKER---------- 728

  Fly   759 QPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYL 823
                                |.|.|                               .|.:|||||
Zfish   729 --------------------RRNSI-------------------------------NRNFVGDYL 742

  Fly   824 ANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIH----- 883
            .....           ..:|...|..|   :|.|:..|.||:...|...|..|:|..:|:
Zfish   743 GMEDR-----------PELRQFMAKRE---RVDFADSVNKFDRRFKSIKRDLILSPKSIYLIGRE 793

  Fly   884 --KLDGIKNKFKD-MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRI-G 944
              |....|.:.|: :||.:.|..:.|:|:|..:|...:.|           |:||..|.|... .
Zfish   794 KIKKGPEKGQIKEVLKRRLDISGIRSVSLSTRQDDFFILH-----------ETEYDSLLESMFKT 847

  Fly   945 EVVGIVCKKYHDLTGTELRVNVTTNISCRLD----------GKARIITVE 984
            |.:.::||:|.:.|    |..:|.:.|.||.          |..|::..:
Zfish   848 EFLTLLCKRYEEQT----RSKLTLSFSDRLQFNVKKEGWGGGSTRMVVFQ 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	298/709 (42%)
		MYSc_Myo1	21..677	CDD:276829	286/681 (42%)
		Myosin_TH1	801..983	CDD:283635	47/200 (24%)
myo1f	NP_001243600.1	MYSc	10..688	CDD:214580	298/710 (42%)
		MYSc_Myo1	29..675	CDD:276829	286/681 (42%)
		Myosin_TH1	715..897	CDD:283635	53/287 (18%)
		SH3_MyoIe_If_like	1042..1094	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2201
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850