DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and myo1d

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_688008.5	Gene:	myo1d / 559562	ZFINID:	ZDB-GENE-130531-15	Length:	1004	Species:	Danio rerio

Alignment Length:	1004	Identity:	523/1004 - (52%)
Similarity:	703/1004 - (70%)	Gaps:	12/1004 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELF 70
            |.|..||||||.||:|:||.||:.||:.|.||:|||||.||:||||.|||||.:.|.:||||||:
Zfish     8 EFGKADFVLLDNVSLEEFMANLKLRFEKGRIYSYIGEVVVSVNPYRAMNIYGRDVIEQYKGRELY 72

  Fly    71 ENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNV 135
            |..||||||||:||:.:|:|.:||||:||||||||||||||.||:||||:||...:.|:|||||:
Zfish    73 ERPPHLFAIADAAYKAMKRRNKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNM 137

  Fly   136 LIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFH 200
            |::||.:||.|||||||||||||||||||||.||:|.||:||.|.|||||||||:.||.|||:||
Zfish   138 LLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIFQQEGERSFH 202

  Fly   201 SFYQLLRGANDNELRQYELQKETGKYHYLNQGSM--DILTEKSDYKGTCNAFKTLGFSTDEVQTI 263
            |||||::||.|.:||...:|::...|:|:..|..  ..:.:.:::|...:|.|.:||:|:|:||:
Zfish   203 SFYQLVKGAPDAQLRSLHIQRDPTAYNYIKVGGQLKSSINDSAEFKAVADAMKVIGFTTEEIQTV 267

  Fly   264 WRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQKDHN 328
            ::.:|.:|||||::|.|..|..:|.|.:.:.....||...|..:..|:..|.:|.|.:|:.|.|.
Zfish   268 YKILATILHLGNLKFGTDGDVTLIENSKLVSVLGDLLSTKEENVEKAMLYRTVATGRDVIDKQHT 332

  Fly   329 ATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQAR-FNSVIGVLDIYGFEIFDSNSFEQ 392
            ..:|.||:||||||||:|||.||:.|||..|..:....:.. .|:|||||||||||||.:|||||
Zfish   333 HQEASYGRDALAKAIYERLFCWIVGRINDIIEVKNYDARVHGKNTVIGVLDIYGFEIFQNNSFEQ 397

  Fly   393 FCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLS 457
            |||||||||||||||:|||||||||||||||.|.:|:||||:||.|||||.||||.|::||||::
Zfish   398 FCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIFAVLDEACMN 462

  Fly   458 VGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKDTL 522
            ||||||:..|.|::..|:||.|||||:|.||||.|:...||||.||||||.|::.|||:||||||
Zfish   463 VGKVTDEMFLQALNGKLAKHAHYTSRKLSPTDKNLEFERDFRIRHYAGDVTYSVVGFIDKNKDTL 527

  Fly   523 YQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRCIKP 587
            :|||||||:||.:..|..|||||...|.:.|||||||.|||:.||..||..|..|||:|||||||
Zfish   528 FQDFKRLLYNSSNPVLKAMWPEGKLSITEVTKRPLTAATLFKNSMISLVEKLASKEPYYVRCIKP 592

  Fly   588 NDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRD 652
            ||:||..:|:.||.:|||.|||||||:|||||||.:||.|.:||.||||||::||||....||::
Zfish   593 NDVKSPLLFEHERCKHQVEYLGLLENVRVRRAGFANRQTYPRFLQRYKMISEFTWPNHDLSSDKE 657

  Fly   653 GVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMK 717
            .|:.|::...|..||.||.||:|||:|||:|:||.||.||:..||..|||..||.:.|..:::|:
Zfish   658 AVKRLLQGCGFEHDVAYGKTKVFIRTPRTIFSLEEQRAEMVKRIVLFLQKVWRGTLARMRYRRMR 722

  Fly   718 AAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANM 782
            ||:.|:|||:.||::||::|:..|.:..:.|:|:||.::||.||...||.|..|..:::.|.|..
Zfish   723 AALIIIRAYRRYKVKSYIREVIRRFKNVRDMKDHGKHVKWPTPPKVLRKFEEALRSIYNRWWAWT 787

  Fly   783 ILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPA 847
            ::......:..|:|.::.....|.|:|...|..|.|.|:||......:.     .|...:.:...
Zfish   788 LIKPLSPEKTVQIRAKVATLECLKGQRADLGLQRAWEGNYLKKDSPGTA-----SSFTLVSSDLQ 847

  Fly   848 DGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPG 912
            ..:.|.:|||||.|:|.|.|||..:||.:::|..::|:|.:| ::|.|| :|.:..:|.:|:|||
Zfish   848 RKDKFMRVLFSSNVRKINRFNKAEDRALLITDRHLYKMDPLK-QYKPMK-SIPLYNVTGVSISPG 910

  Fly   913 RDQLIVFHSSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGK 977
            :|||:|||:..|:||:..|:. ..|..:.||||:||.:...:.. ...:|:||..:.|.|.::|:
Zfish   911 KDQLVVFHTKDNRDLIVCLQG-MVPAGDSRIGELVGTLLSHFKS-EKRKLQVNTVSPIHCSMNGR 973

  Fly   978 ARIITVEAASNVEVPNFRPKEGNIIFEVP 1006
            ...:.||...:...|:|.......|..||
Zfish   974 KCTVVVETKISQSQPDFTKSRSGYILSVP 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	416/686 (61%)
		MYSc_Myo1	21..677	CDD:276829	397/658 (60%)
		Myosin_TH1	801..983	CDD:283635	60/181 (33%)
myo1d	XP_688008.5	MYSc_Myo1	23..682	CDD:276829	397/658 (60%)
myo1d	XP_688008.5	Myosin_TH1	803..994	CDD:336273	64/199 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	837	1.000	Domainoid score	I62
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45576
Inparanoid	1	1.050	1053	1.000	Inparanoid score	I252
OMA	1	1.010	-	-		QHG53790
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		otm26325
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2201
SonicParanoid	1	1.000	-	-		X2270
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870