Protein Alignment Myo31DF and MYO5C

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_061198.2
• Gene: MYO5C / 55930
• HGNCID: 7604
• Length: 1742
• Species: Homo sapiens
• Alignment Length: 1027
• Identity: 325/1027 - (31%)
• Similarity: 504/1027 - (49%)
• Gaps: 144/1027 - (14%)

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRF-QNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71
            |..|...|..:.....:.|||.|| ::..||||.|.:.|:||||:|:.|||...|..|.|:.:.:
Human    68 GENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGD 132

  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVL 136
            ..||:||:|:.||:.:.:..::..|::|||||||||.:::..|:|.|.|:.: |.|  ..|::.:
Human   133 MDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS-GSN--AHVEDKV 194

  Fly   137 IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHS 201
            :.||.|.|..|||||.|||||||||||.:|.||.:...:|..::.|||||||||.|...|||:|.
Human   195 LASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHI 259

  Fly   202 FYQLLRGANDNELRQYELQKETGKYHYLNQGSMDIL---TEKSDYKGTCNAFKTLGFSTDEVQTI 263
            ||||...|..:|.:..:| ....:::|...|...::   .::::...|...|..|||..|....:
Human   260 FYQLCASAQQSEFKHLKL-GSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDV 323

  Fly   264 WRTIAAVLHLGNVEFQTIEDE--LVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQKD 326
            ::.:||:||||||:...:.:|  .|..:..|||...:||.:....::..|..|.|......:.|.
Human   324 FKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKP 388

  Fly   327 HNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFE 391
            ....||...:|||||.||..||.:|:.|||:|:.|.|.:     ::.||||||||||.||.||||
Human   389 MTRPQAVNARDALAKKIYAHLFDFIVERINQALQFSGKQ-----HTFIGVLDIYGFETFDVNSFE 448

  Fly   392 QFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACL 456
            ||||||.||||||.|...|.|.|||||.:|.|.||.|::::|:.:.||:| ...||:.::||.||
Human   449 QFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIE-AKMGILELLDEECL 512

  Fly   457 SVGKVTDDTLLGAMDKN-LSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKD 520
             :...||:..|..:..| ::::|.:...::..|        .|.|.|:|..|.|...||:|||:|
Human   513 -LPHGTDENWLQKLYNNFVNRNPLFEKPRMSNT--------SFVIQHFADKVEYKCEGFLEKNRD 568

  Fly   521 TLYQDFKRLLHNSK--------DANLSEMWPEGAQDIKKTTKRPL---------TAGTLFQRSMA 568
            |:|.....:|..||        ..|.:...|.|:....|:.|:.:         |.|:.|:.|:.
Human   569 TVYDMLVEILRASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLY 633

  Fly   569 DLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLR 633
            .|:.||....|.|||||||||.|....||.:|:..|:|..|:||.:|:....:..|..|.:|..|
Human   634 LLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSR 698

  Fly   634 YKMISQYTWPNFRAGSDRDGV-RVLIEEKKFAQD---VKYGHTKIFIRSPRTLFALEHQRNEMIP 694
            |.::......:|   ||:..| :|::.  :..||   .::|.||||.|:.:..: ||..|.:.:.
Human   699 YGILMTKQELSF---SDKKEVCKVVLH--RLIQDSNQYQFGKTKIFFRAGQVAY-LEKLRLDKLR 757

  Fly   695 HIVTLLQKRVRGWIVRRNFKKMKAAITIVRAY-----------------------------KAYK 730
            ....::||.:|||:.|:.|.:.:.|..|::.|                             :.|.
Human   758 QSCVMVQKHMRGWLQRKKFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYL 822

  Fly   731 LRSYVQELANRLRKAK-QMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQ 794
            :||..|    .:|.|. .|:.|.:..      ||.|    :..:|.:..:| :||.||.|:...:
Human   823 VRSLYQ----LIRMATITMQAYSRGF------LARR----RYRKMLEEHKA-VILQKYARAWLAR 872

  Fly   795 LRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGY--------EAYNGSIKNI--------- 842
            .|.|.|....|..:..|  :.:|........::||.|.        ....|.::.|
Human   873 RRFQSIRRFVLNIQLTY--RVQRLQKKLEDQNKENHGLVEKLTSLAALRAGDVEKIQKLEAELEK 935

  Fly   843 -----RNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNK--------FKD 894
                 ||:...|:.::..:.....|...|.::...:...:......|.:.:|.|        |.|
Human   936 AATHRRNYEEKGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDD 1000

  Fly   895 MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDL---VFSLESEYTPLKEDRI 943
            :::..:.|.|...|           ...|.:|.   :.||:.|...||::::
Human  1001 VQKEERQRMLLEKS-----------FELKTQDYEKQIQSLKEEIKALKDEKM 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	259/683 (38%)
		Myosin_TH1	801..977	CDD:461801	28/176 (16%)
MYO5C	NP_061198.2	MYSc_Myo5	81..741	CDD:276831	259/683 (38%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	632..654		11/21 (52%)
		IQ	810..828	CDD:197470	3/17 (18%)
		IQ	831..851	CDD:459869	7/29 (24%)
		SMC_prok_B	<886..>1356	CDD:274008	27/169 (16%)
		Myo5c_CBD	1369..1736	CDD:271260