DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYO5C

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_061198.2	Gene:	MYO5C / 55930	HGNCID:	7604	Length:	1742	Species:	Homo sapiens

Alignment Length:	1027	Identity:	325/1027 - (31%)
Similarity:	504/1027 - (49%)	Gaps:	144/1027 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRF-QNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71
            |..|...|..:.....:.|||.|| ::..||||.|.:.|:||||:|:.|||...|..|.|:.:.:
Human    68 GENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGD 132

  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVL 136
            ..||:||:|:.||:.:.:..::..|::|||||||||.:::..|:|.|.|:.: |.|  ..|::.:
Human   133 MDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS-GSN--AHVEDKV 194

  Fly   137 IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHS 201
            :.||.|.|..|||||.|||||||||||.:|.||.:...:|..::.|||||||||.|...|||:|.
Human   195 LASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHI 259

  Fly   202 FYQLLRGANDNELRQYELQKETGKYHYLNQGSMDIL---TEKSDYKGTCNAFKTLGFSTDEVQTI 263
            ||||...|..:|.:..:| ....:::|...|...::   .::::...|...|..|||..|....:
Human   260 FYQLCASAQQSEFKHLKL-GSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDV 323

  Fly   264 WRTIAAVLHLGNVEFQTIEDE--LVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQKD 326
            ::.:||:||||||:...:.:|  .|..:..|||...:||.:....::..|..|.|......:.|.
Human   324 FKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKP 388

  Fly   327 HNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFE 391
            ....||...:|||||.||..||.:|:.|||:|:.|.|.:     ::.||||||||||.||.||||
Human   389 MTRPQAVNARDALAKKIYAHLFDFIVERINQALQFSGKQ-----HTFIGVLDIYGFETFDVNSFE 448

  Fly   392 QFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACL 456
            ||||||.||||||.|...|.|.|||||.:|.|.||.|::::|:.:.||:| ...||:.::||.||
Human   449 QFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIE-AKMGILELLDEECL 512

  Fly   457 SVGKVTDDTLLGAMDKN-LSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKD 520
             :...||:..|..:..| ::::|.:...::..|        .|.|.|:|..|.|...||:|||:|
Human   513 -LPHGTDENWLQKLYNNFVNRNPLFEKPRMSNT--------SFVIQHFADKVEYKCEGFLEKNRD 568

  Fly   521 TLYQDFKRLLHNSK--------DANLSEMWPEGAQDIKKTTKRPL---------TAGTLFQRSMA 568
            |:|.....:|..||        ..|.:...|.|:....|:.|:.:         |.|:.|:.|:.
Human   569 TVYDMLVEILRASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLY 633

  Fly   569 DLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLR 633
            .|:.||....|.|||||||||.|....||.:|:..|:|..|:||.:|:....:..|..|.:|..|
Human   634 LLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSR 698

  Fly   634 YKMISQYTWPNFRAGSDRDGV-RVLIEEKKFAQD---VKYGHTKIFIRSPRTLFALEHQRNEMIP 694
            |.::......:|   ||:..| :|::.  :..||   .::|.||||.|:.:..: ||..|.:.:.
Human   699 YGILMTKQELSF---SDKKEVCKVVLH--RLIQDSNQYQFGKTKIFFRAGQVAY-LEKLRLDKLR 757

  Fly   695 HIVTLLQKRVRGWIVRRNFKKMKAAITIVRAY-----------------------------KAYK 730
            ....::||.:|||:.|:.|.:.:.|..|::.|                             :.|.
Human   758 QSCVMVQKHMRGWLQRKKFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYL 822

  Fly   731 LRSYVQELANRLRKAK-QMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQ 794
            :||..|    .:|.|. .|:.|.:..      ||.|    :..:|.:..:| :||.||.|:...:
Human   823 VRSLYQ----LIRMATITMQAYSRGF------LARR----RYRKMLEEHKA-VILQKYARAWLAR 872

  Fly   795 LRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGY--------EAYNGSIKNI--------- 842
            .|.|.|....|..:..|  :.:|........::||.|.        ....|.::.|
Human   873 RRFQSIRRFVLNIQLTY--RVQRLQKKLEDQNKENHGLVEKLTSLAALRAGDVEKIQKLEAELEK 935

  Fly   843 -----RNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNK--------FKD 894
                 ||:...|:.::..:.....|...|.::...:...:......|.:.:|.|        |.|
Human   936 AATHRRNYEEKGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDD 1000

  Fly   895 MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDL---VFSLESEYTPLKEDRI 943
            :::..:.|.|...|           ...|.:|.   :.||:.|...||::::
Human  1001 VQKEERQRMLLEKS-----------FELKTQDYEKQIQSLKEEIKALKDEKM 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	265/709 (37%)
		MYSc_Myo1	21..677	CDD:276829	259/683 (38%)
		Myosin_TH1	801..983	CDD:283635	28/176 (16%)
MYO5C	NP_061198.2	Myosin_N	12..48	CDD:280832
		MYSc	62..752	CDD:214580	265/708 (37%)
		MYSc_Myo5	81..741	CDD:276831	259/683 (38%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	632..654		11/21 (52%)
		IQ	810..828	CDD:197470	3/17 (18%)
		COG1340	890..1150	CDD:224259	26/163 (16%)
		P-loop_NTPase	<910..>1163	CDD:304359	22/143 (15%)
		GBP_C	<927..1030	CDD:303769	16/113 (14%)
		coiled coil	997..1010	CDD:293879	3/12 (25%)
		coiled coil	1019..1030	CDD:293879	2/10 (20%)
		Rab5-bind	1020..1345	CDD:286404	6/22 (27%)
		DUF3585	1160..1326	CDD:304905
		Myo5c_CBD	1369..1736	CDD:271260
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910