DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo31DF and LOC556989

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_685035.4	Gene:	LOC556989 / 556989	-ID:	-	Length:	1124	Species:	Danio rerio

Alignment Length:	833	Identity:	277/833 - (33%)
Similarity:	424/833 - (50%)	Gaps:	84/833 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENAP 74
            :|...|.::..:..::.|..||....||||||::.|::||::.::||..|..::||..|.....|
Zfish    42 EDLANLSELDEKCLLEVLTGRFTQNLIYTYIGDILVAINPFKYLSIYEKEVSQRYKCHEKKSLPP 106

  Fly    75 HLFAIADSAYRVLKQR----QQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNV 135
            |:||:||.||:.:..|    .::.||:|||||||||||::|:::::|..:..|..|.|.:
Zfish   107 HIFAVADRAYQSMLGRLAMGPKNQCIVISGESGAGKTESTKLLLRHIMELCKANSQLEQQ----- 166

  Fly   136 LIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFH 200
            ::|.|.:||.||||:|..||||||||||:.:.|. .:...|..|..|||||||||.|..||:|||
Zfish   167 ILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRFQ-NSSVKGAKINEYLLEKSRVVHQDQGEQNFH 230

  Fly   201 SFYQLLRGANDNELRQYELQKETGKYHYLNQ--GSMDIL-TEKSDYKGTCNAFKTLGFSTDEVQT 262
            .||.:|.|.:..:...|.|...| .|.|||.  |..|:: |.:..|...|||...:||...|...
Zfish   231 IFYLMLAGISLEDKEIYGLLDPT-LYRYLNGRFGQEDVVQTWRVKYAEVCNAMDMVGFEEQEKVD 294

  Fly   263 IWRTIAAVLHLGNVEFQTIE-DELVIS--NKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQ 324
            :...:|.:|.|||:.|:|.: |.|.:|  ::..||:||....|.|.:|..:||.......|..:|
Zfish   295 MMTILAGILSLGNITFETTDSDALKVSEASRGWLKATAGQFGVQEEDLLKSLTCTTSMTRGEAIQ 359

  Fly   325 KDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFN---SVIGVLDIYGFEIFD 386
            :.||..|||..:|::||..|.|:|.||:|:||..:     ..:..|:   :.||:|||:|||.|.
Zfish   360 RLHNQQQAEDARDSIAKVAYGRVFGWIVSKINEQL-----APKVDFDVELNEIGILDIFGFENFA 419

  Fly   387 SNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIM 451
            .|.|||.|||..||:||..|...:...||:||:.|||.|..|.|.:||.|.||......||::::
Zfish   420 VNRFEQLCINLANEQLQYFFNHHIFLMEQKEYKEEGITWETITYKDNKPILDLFLMKPIGILSLL 484

  Fly   452 DEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIE 516
            ||.. :..:.||...:..::......|::        :....|...|.:.||||.|.||.:||:|
Zfish   485 DEQS-AFPQATDRDFVDKLNSKFKSAPNF--------EVVRNHTPLFTVVHYAGKVQYNASGFLE 540

  Fly   517 KNKDTLYQDFKRLLHNSKDANLSEMW-----------PEGAQ----DIKKTTKRPLTAGTLFQRS 566
            ||:||:....:.|..||....||.::           |..|:    |....:.|..:.|..|:.|
Zfish   541 KNRDTIPASIRELFINSVTPLLSVLFAATISRTGTLMPRKAKLQVSDDNFNSTRKQSVGAQFKHS 605

  Fly   567 MADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFL 631
            :|.|:..:....|.:|||||||..|.....|.:.|..|:||.||:|.:|:||.||..|..:.:|.
Zfish   606 LAVLMEKMFAASPHFVRCIKPNRSKQPDQLDSKLVLDQLRYNGLMETIRIRRDGFSWRPTFREFA 670

  Fly   632 LRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHI 696
            .||.::  ...|:.  .:|:.....::...:.: ..|.|.:::|       |.|.||     ..:
Zfish   671 ERYNIL--LLKPDL--PTDKSSCMSILNSTELS-GWKCGSSRLF-------FKLCHQ-----VEL 718

  Fly   697 VTLLQKRVR-GWIVRRNFKKMKAAITIVRAY-----KAYKLRSYVQELANRLRKAKQMRDYGKSI 755
            ..||.:..| ..::::||:    |.|..|.|     :..:.|...:|...|..:.::.::..|..
Zfish   719 ANLLDRLGRAALVIQKNFR----ARTCRRKYLCLLAELRRQRQAQREREEREEEERRRQEEEKRR 779

  Fly   756 QWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLR----LQIIAATA 804
            |..|.....|::|.:...:    |........||.:.|:.|    |..|:.||
Zfish   780 QQQQEAERKRRLEVEQENL----RPASPPVPLPRKKKPEPRPRSVLSSISKTA 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	251/707 (36%)
		MYSc_Myo1	21..677	CDD:276829	245/683 (36%)
		Myosin_TH1	801..983	CDD:283635	2/4 (50%)
LOC556989	XP_685035.4	MYSc	34..711	CDD:214580	247/701 (35%)
		MYSc_Myo28	53..711	CDD:276854	245/690 (36%)
		SH2	895..992	CDD:301589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910