DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and myo1ha

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_009299653.1	Gene:	myo1ha / 556606	ZFINID:	ZDB-GENE-060531-78	Length:	1059	Species:	Danio rerio

Alignment Length:	1031	Identity:	401/1031 - (38%)
Similarity:	583/1031 - (56%)	Gaps:	112/1031 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVQDFVLLDQVSME-KFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71
            |:|||||||..:.| .|:|||:|||....||||||.:.:|:|||::::||..:.:..|.|...||
Zfish    47 GIQDFVLLDAHNSETAFLDNLKKRFTEDLIYTYIGTLLISVNPYKELDIYTKKQMDLYMGVNFFE 111

  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVL 136
            ..||::|:||:||..:.....:..||||||||||||||||.|::|.|  .:......::.|::.:
Zfish   112 LPPHIYALADNAYHTMLSEANNHFILISGESGAGKTEASKKILQYYA--VSCPSSTLLDTVRDRM 174

  Fly   137 IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHS 201
            :.||.:||.||||||.:|||||||||||||:||.:.|.|||.|.:|||||||||.|..||||||.
Zfish   175 LMSNPVLEAFGNAKTMKNDNSSRFGKYMDIQFDIQGDAVGGHILSYLLEKSRVVHQNHGERNFHI 239

  Fly   202 FYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQTI 263
            ||||:.|..::.|||..|:::|.:|.||.||   ::..:.:|:|:|...||...:.|...:.:.:
Zfish   240 FYQLVEGGEEDLLRQLGLERDTKRYCYLVQGECSNVSSINDKNDWKTVKNALSVIDFDASDTEHL 304

  Fly   264 WRTIAAVLHLGNVEF-QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQKDH 327
            :..|::|||||||.| :..:...::::...|:..:|||.|....|..|||.|.|.|....:...:
Zfish   305 FGIISSVLHLGNVHFDRDTKGYAILNSNAALRWVSKLLGVHVQVLHGALTFRKIEAKSEEVLSPY 369

  Fly   328 NATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQ 392
            ....|.|.:||||||||||.|||:::|||.::..:.|:.:    :|||:|||||||:|.:|||||
Zfish   370 TVDHAIYARDALAKAIYDRAFTWLVNRINESLENKDSERK----TVIGLLDIYGFEVFTANSFEQ 430

  Fly   393 FCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLS 457
            |||||||||||||||:|.||.|||||:.|||.|..:::|||||||||||:.|:|||:::||.|:.
Zfish   431 FCINYCNEKLQQLFIQLTLKAEQEEYEAEGIGWEPVQFFNNKIICDLVEEKHRGIISVLDEECVR 495

  Fly   458 VGKVTDDTLLGAMDKNLSKHPHYTSRQL--KPTDKELKHREDFRITHYAGDVIYNINGFIEKNKD 520
            .|..||.|.|..:::.:..|||:.:.:|  |.|.|.|: |.|||:.||||:|.|.:.|||:||.|
Zfish   496 PGDATDLTFLEKLEEKMGNHPHFVTHKLADKKTRKSLE-RGDFRLLHYAGEVTYCVVGFIDKNND 559

  Fly   521 TLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRCI 585
            .||::.|.::..||:..:.:.:|....:   :.:||.|..|.|:.|:..|...|..||.:||||:
Zfish   560 LLYKNIKDMMRLSKNPIIQQCFPATKAE---SRRRPETVATQFKNSLLRLTEILTAKEAWYVRCL 621

  Fly   586 KPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSD 650
            |.||.|....|||..|.|||:||||:|:||||||||.:|::|:.||.|||.:...|||::| |..
Zfish   622 KSNDNKQQGKFDEVLVRHQVKYLGLMEHLRVRRAGFAYRRKYEVFLKRYKPLCPATWPHWR-GVP 685

  Fly   651 RDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTLFALEHQRNEMIPH-IVTLLQKRVRGWIVRRNF 713
            .:||..|::...:..| .|.|.||||||..|||||.| ...|:..| :.|.||.:.:|:.|:..|
Zfish   686 SEGVEKLVQHLGYQPDEYKMGRTKIFIRYARTLFATE-DAFEICKHELATKLQAKYKGYKVKGEF 749

  Fly   714 KKMKAAITIV---------------RAYKAYKLRSYV----------------------QELANR 741
            :|.|.|.|.:               ||:....::.::                      |...||
Zfish   750 RKQKEAATKIETCWRGVQARKERDRRAWAVKVIKKFIKGYLTRREAKTTDNSEYLAFVRQSYLNR 814

  Fly   742 LRKAKQMRDYGKSIQWPQPP---LAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQ----I 799
            | ||...:.......|..||   ....::..|||       ..|::.||.|...||.:.|    :
Zfish   815 L-KANLPKTVLDKTTWLTPPPVMTETSEILRKLH-------TRMMVRKYVRGITPQKKAQMQQKV 871

  Fly   800 IAATALAGRRPYWGQ--ARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVK 862
            :.:....|::..:..  |..:| |...|.|:      .|..:.....|       :::.:|..|.
Zfish   872 VTSAIFKGKKDSYPSSIAVPFV-DTRINEQD------INMRVLQTIRH-------ERIKYSVPVV 922

  Fly   863 KF--NHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSKNK 925
            |:  |.| |...|..|::.:..|.::..|     :|:.:....|...|||...|.:::.|.:.|.
Zfish   923 KYDRNGF-KPRQRQLILTQAAAHLVEEAK-----IKQRVDYVSLKGASVSNLGDSVMILHVAFND 981

  Fly   926 -----DLVFSLESEYTPL--------KEDRIGEVVGIVCKKYHDLTGTELRVNVTT 968
                 |||...:..:..|        |::.|..|.|.:  |:....|.:..|:.:|
Zfish   982 PKQKGDLVLQCDHLFEALTKLAMIANKQNNITVVQGSI--KFEIQAGKQNAVDFST 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	330/689 (48%)
		MYSc_Myo1	21..677	CDD:276829	314/663 (47%)
		Myosin_TH1	801..983	CDD:283635	38/185 (21%)
myo1ha	XP_009299653.1	MYSc	43..724	CDD:214580	330/688 (48%)
		MYSc_Myo1	62..713	CDD:276829	313/661 (47%)
		Myosin_TH1	870..1037	CDD:283635	38/188 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720