DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo28B1

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	283/776 - (36%)
Similarity:	432/776 - (55%)	Gaps:	75/776 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMQREAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYK 65
            |.:..:..|:|.:.|..:.....:.||:.|:....||||.|.:.|::|||:.:.||....|:.|:
  Fly    61 MHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYR 125

  Fly    66 GRELFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIE 130
            .:.|.|..||:|||:|:|::.|::.:::.|::|||||||||||::|:|::|:||::.....
  Fly   126 NKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSW---- 186

  Fly   131 RVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPG 195
             ::..:|::|.|:|.||||||.|||||||||||::|.|..:....|..|..|||||||:|.|...
  Fly   187 -IEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRD 250

  Fly   196 ERNFHSFYQLLRGANDNELRQYELQKET-GKYHYLNQGSMDILTEKSDYKGTCN---AFKTLGFS 256
            |||:|.||.:|.|.:..|..:.:||::: .:||||.||....|..:.|.|...:   |.|.|.|.
  Fly   251 ERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFK 315

  Fly   257 TDEVQTIWRTIAAVLHLGNVEFQTIE----DELVISNKQHLKSTAKLLQVTETELSTALTKRVIA 317
            .:||.:|...:||:|||||:.|...|    ....|.:..:|:..|:||.:..:.|:.|||:|.|.
  Fly   316 PEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIF 380

  Fly   318 AGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGF 382
            ..|..:....:...|..|:||..|::||.:|..|:.|||..|   ..:.....|| ||||||:||
  Fly   381 VHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETI---NKQVDQPMNS-IGVLDIFGF 441

  Fly   383 EIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGI 447
            |.||:|||||.||||.||.|||.|:..:.|.||:|||.|.|.|.:||:.:|:.|.||:......:
  Fly   442 ENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNL 506

  Fly   448 IAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQL----KPTDKELKHREDFRITHYAGDVI 508
            ::::||.. ...|.||.|||..:      |..:.:|.:    |.|...|     |.|.||||.|:
  Fly   507 MSLIDEES-KFPKGTDQTLLEKL------HVQHGNRSIYVKGKTTQTSL-----FGIRHYAGVVM 559

  Fly   509 YNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWP-EGAQDIKKTTKRPLTAGTLFQRSMADLVV 572
            ||..||:|||:|:...|.:.|:..|.:..|.:::| |...|   |.|:..|....|:.|:..|:.
  Fly   560 YNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMD---TAKKQPTLCVKFRNSLDMLMR 621

  Fly   573 TLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMI 637
            ||.:..|:::||||||:.|....||:|....|:||.|::|..|:||||:..|..|..|:.||:::
  Fly   622 TLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLL 686

  Fly   638 SQYTWPNFRAGSDRDGVRVLIEE---KKFAQ-----------DVKYGHTKIFIRSPRTLFALEHQ 688
            .....|              :|:   :|.|:           |.:||.||:|:|..... :||.|
  Fly   687 VPPVGP--------------LEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDA-SLELQ 736

  Fly   689 RNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMR 749
            |::::...:..:|:.:|..:.||..|:.:.||..|:.|...:|:.         ||.:.||
  Fly   737 RSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQR---------RKYQVMR 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	267/710 (38%)
		MYSc_Myo1	21..677	CDD:276829	260/682 (38%)
		Myosin_TH1	801..983	CDD:283635
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	266/713 (37%)
		MYSc_Myo7	81..726	CDD:276832	260/682 (38%)
		IQ	765..785	CDD:197470	7/28 (25%)
		DUF4355	827..>887	CDD:290964
		MyTH4	1031..1239	CDD:295320
		B41	1248..1429	CDD:214604
		FERM_N	1248..>1288	CDD:286467
		FERM_B-lobe	1342..1429	CDD:271216
		PH-like	1454..1547	CDD:302622
		MyTH4	1674..1819	CDD:214535
		B41	1827..2032	CDD:214604
		FERM_N	1829..>1877	CDD:286467
		FERM_M	1936..2032	CDD:278785
		FERM_C2_MyoVII	2028..2121	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940