DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and myo1e.2

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001011082.1	Gene:	myo1e.2 / 496494	XenbaseID:	XB-GENE-5913944	Length:	1093	Species:	Xenopus tropicalis

Alignment Length:	1057	Identity:	359/1057 - (33%)
Similarity:	539/1057 - (50%)	Gaps:	208/1057 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            |::||.|.|||.:::.|..|:||:||:.:..|:||||.|.:|:||::|:..:....|..|:|...
Frog    15 RQSGVDDMVLLSKITEEAIMENLKKRYMDDYIFTYIGPVLISVNPFKQLPYFTDREIEMYQGAAQ 79

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            :||.||::|:||:.||.:....::.|::||||||||||.|:|.||.|::.|:.  |..:::.||:
Frog    80 YENPPHIYALADTMYRNMLIDGENQCVIISGESGAGKTVAAKYIMGYVSKVSG--GGPKVQHVKD 142

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
            ::::||.:||.||||||.||:||||||||.:|:|....:|.||.|:|:||||||||.|..|||:|
Frog   143 IILKSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNSGERSF 207

  Fly   200 HSFYQLLRGANDNELRQYELQKET------GKYHYLNQGS---MDILTEKSDYKGTCNAFKTLGF 255
            |.|||||.||:..:       ||.      ..|.||||.:   :|.:::|.::..|..|...:|.
Frog   208 HIFYQLLEGASAED-------KENLGVTSPDYYFYLNQSAVYHVDDVSDKKEFAETMLAMDVVGL 265

  Fly   256 STDEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA-- 318
            ..|...::.:.:|.:||||||.|....:..|:.::..|...|.||.:.:..|...||.|.:.:
Frog   266 GPDTQTSVLQIVAGILHLGNVAFTESGNHAVVESQDFLAFPAYLLGIDQARLQDKLTSRKMDSKW 330

  Fly   319 GG--NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYG 381
            ||  .|:....||.||.:.:||||||:|.|||.:::..||:|:    .|....:|  ||||||||
Frog   331 GGKSEVIDVTLNAEQACFTRDALAKALYTRLFDFLVEAINKAM----RKDTEEYN--IGVLDIYG 389

  Fly   382 FEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQ--PH 444
            ||||..|.|||||||:.||||||:||||.||.|||||.:|||.|..|||||||::|||:|.  ..
Frog   390 FEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIHWNPIEYFNNKVVCDLIESKVSP 454

  Fly   445 KGIIAIMDEACLSV---GKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGD 506
            .|:::|:|:.|.::   |:..|.|||..:...:..|.|:.|           ....|.|.||||.
Frog   455 PGVMSILDDVCATMHAKGEGADQTLLQKLQSAIGSHEHFNS-----------WNRGFIIHHYAGK 508

  Fly   507 VIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLV 571
            |.|:::||.|:|:|.|:.|...|:.:|:...:.|.:||.....||  .||.|||:..::...|||
Frog   509 VSYDVSGFCERNRDVLFVDLIELMQSSEIPFIRERFPENLNAEKK--GRPSTAGSKIKKQANDLV 571

  Fly   572 VTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKM 636
            .||:|..|.|:||||||:.|....:::.||:|||.||||.||:||||||:.:|:.:.|||.||.:
Frog   572 QTLMKCTPHYIRCIKPNETKKPRDWEDSRVKHQVEYLGLRENIRVRRAGYAYRRVFQKFLHRYAI 636

  Fly   637 ISQYTWPNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLL 700
            :::.|||.:| |.::.||..|:.......| .:.|.||:||::|.:||.||..|.....:...::
Frog   637 LTRETWPQWR-GDEKKGVMHLLRSVNMDSDQYQLGRTKVFIKAPESLFLLEEMRERKYDNYARVI 700

  Fly   701 QKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGR 765
            ||..|                     |...:|.|:           :||:...||...|...
Frog   701 QKAWR---------------------KHTAVRKYI-----------RMREEASSIVLNQKER--- 730

  Fly   766 KVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENS 830
                         |.|.|                               .|.:||||:.
Frog   731 -------------RRNSI-------------------------------NRNFVGDYIG------ 745

  Fly   831 GYEAYNGSIKNIRNHPADGE--------TFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIH---- 883
                            .||.        ..:::.|:..|.|::...|...|..:::...::
Frog   746 ----------------MDGRPELRQFVGRRERIDFADVVTKYDRRFKTLKRDLVLTPKFLYLIGR 794

  Fly   884 ---KLDGIKNKFKD-MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRIG 944
               |....|.:.|: :||.|::..:.|:|:|..:|..|:.|......   :||..:..
Frog   795 EKVKQGPDKGQIKEVLKRKIELENIQSVSLSKLQDDFIILHEGAYDS---ALEGVFKT------- 849

  Fly   945 EVVGIVCKKYHDLTGTEL--------------------------RVNVTTNIS----CRLDGKAR 979
            |.:.::.|:|.:.|..:|                          ::...|.|.    .:.:||..
Frog   850 EFLSLLYKRYEEKTHRKLPIKFGLQLEFKVKKEGWAPWGAAGTRQIQFQTGIGDMALTKANGKVL 914

  Fly   980 IITVEAASNVEVPNFRP 996
            |:|:....   .||.||
Frog   915 IVTIGPGL---PPNSRP 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	302/702 (43%)
		MYSc_Myo1	21..677	CDD:276829	290/674 (43%)
		Myosin_TH1	801..983	CDD:283635	36/227 (16%)
myo1e.2	NP_001011082.1	MYSc_Myo1	31..677	CDD:276829	290/674 (43%)
		Myosin_TH1	717..918	CDD:368706	43/279 (15%)
		SH3_MyoIe_If_like	1040..1092	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010