Protein Alignment Myo31DF and MYO10

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_036466.2
• Gene: MYO10 / 4651
• HGNCID: 7593
• Length: 2058
• Species: Homo sapiens
• Alignment Length: 1052
• Identity: 328/1052 - (31%)
• Similarity: 514/1052 - (48%)
• Gaps: 164/1052 - (15%)

  Fly     6 EAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQM-NIYGPETIRKYKGREL 69
            |.||.|...|.::.....|.||.:|::...||||||.:..|:|||:.: .:|.|.|:.:|..|.|
Human    62 EEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPATMEQYSRRHL 126

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIER--- 131
            .|..||:||||:..||.|.:|..:.||||||||||||||::|:|:|:::.::....:..::.
Human   127 GELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVISQQSLELSLKEKTS 191

  Fly   132 -VKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPG 195
             |:..:::|:.|:|.||||||..|:|||||||::.:....|.:..||.|.:|||||:|||:|.||
Human   192 CVERAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPG 256

  Fly   196 ERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQ-GSMD--ILTEKSDYKGTCNAFKTLGFST 257
            |||:|.||.||.|....|..::.|.... .|||||| |.::  .::::..::....|...:.||.
Human   257 ERNYHIFYALLAGLEHEEREEFYLSTPE-NYHYLNQSGCVEDKTISDQESFREVITAMDVMQFSK 320

  Fly   258 DEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNV 322
            :||:.:.|.:|.:|||||:||.|.....| |.|..|..:|:||.:..|:|:.|||:|.:...|..
Human   321 EEVREVSRLLAGILHLGNIEFITAGGAQV-SFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEE 384

  Fly   323 MQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDS 387
            :....|..||...:|:||.|:|...|.|:|.:||..|     |....|.| ||:|||:|||.|:.
Human   385 ILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRI-----KGNEDFKS-IGILDIFGFENFEV 443

  Fly   388 NSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMD 452
            |.||||.|||.|||||:.|.:.:...||.||.|||:.|.:|::.:|....||:|: ..|::|:::
Human   444 NHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIEK-KLGLLALIN 507

  Fly   453 EACLSVGKVTDDTLLGAMDKNLSKHP--HYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFI 515
            |.. ...:.||.|||   :|..|:|.  |:   .:||....    .:|.:.||||:|.|::.|.:
Human   508 EES-HFPQATDSTLL---EKLHSQHANNHF---YVKPRVAV----NNFGVKHYAGEVQYDVRGIL 561

  Fly   516 EKNKDTLYQDFKRLLHNSKDANLSEMW----PEGAQDIKK---TTKRPLTAGTLFQRSMADLVVT 573
            |||:||...|...||..|:...:.:::    ....||..|   ..:|| |..:.|:.|:..|:.|
Human   562 EKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRP-TVSSQFKDSLHSLMAT 625

  Fly   574 LLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMIS 638
            |....||:|||||||..|....||:..|.:|:||.|:||.:|:|:||:..|:.:..|..|||::.
Human   626 LSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLM 690

  Fly   639 QYTWPNFRAGSDRDGVRVLIEEKKFAQDVKY--GHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQ 701
            :    |.....|..|....:.:...|.:.::  |.||:|:|..... .||.:|.|.:.|...:::
Human   691 R----NLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQ-KLEKRREEEVSHAAMVIR 750

  Fly   702 KRVRGWIVRRNFKKMKAAITIV-RAYKAYKLRS------------------------YVQELANR 741
            ..|.|::.|:.::|:...:.|: :.|:|:.||.                        |.|.||.:
Human   751 AHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEK 815

  Fly   742 L---RKAKQMRDYGKS--------------------------IQWPQPPLAGRKVEAKLHRMFDF 777
            .   .|.||..:..|.                          .|.....|...:.||:|.|..:.
Human   816 REQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEK 880

  Fly   778 WRANMILHKYPR-----------SEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQ---E 828
            .:.|..:.:..|           .|..:|.|...:...|..||..  :.||...:....:|   |
Human   881 QKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQ--ELRRLEEEACRAAQEFLE 943

  Fly   829 NSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFN-------KQANRAFIVSDSTIHKLD 886
            :..::..:..::||....:.|..|...|..|..::..:||       ::.:..|...|
Human   944 SLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDEGFEADD------- 1001

  Fly   887 GIKNKFKDM----------KRTIKIREL------------TSISVSPGRDQLIV----------F 919
               :.|||.          :||..||..            |.:..||..|..::          .
Human  1002 ---DAFKDSPNPSEHGHSDQRTSGIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSL 1063

  Fly   920 HSSKNKDLVFSL 931
            |:|.:.:..:.:
Human  1064 HNSSSGESTYCM 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	259/674 (38%)
		Myosin_TH1	801..977	CDD:461801	30/173 (17%)
MYO10	NP_036466.2	SH3_19	7..58	CDD:465815
		MYSc_Myo10	77..727	CDD:276840	259/674 (38%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	619..641		11/21 (52%)
		SMC_N	727..>958	CDD:481474	42/233 (18%)
		SAH. /evidence=ECO:0000269|PubMed:23012428	814..883		10/68 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..840		4/20 (20%)
		PTZ00108	<846..1161	CDD:240271	41/242 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	847..866		1/18 (6%)
		DUF5401	<848..967	CDD:375164	21/120 (18%)
		MYO10_CC	883..933	CDD:465249	10/51 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1090		21/122 (17%)
		PH-like	1181..>1223	CDD:473070
		PH2_MyoX	1215..1316	CDD:270108
		PH3_MyoX-like	1381..1506	CDD:270109
		MyTH4	1549..1695	CDD:214535
		FERM_F1_Myosin-X	1697..1792	CDD:340726
		B41	1704..1958	CDD:214604
		FERM_C_MyoX	1954..2042	CDD:270023