DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYO7A

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_011543348.2	Gene:	MYO7A / 4647	HGNCID:	7606	Length:	2258	Species:	Homo sapiens

Alignment Length:	825	Identity:	297/825 - (36%)
Similarity:	465/825 - (56%)	Gaps:	60/825 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFEN 72
            ||:|.:.|..::....:.||..|:::..||||.|.:.|::|||:.::||.||.||:|..:::.|.
Human    96 GVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEM 160

  Fly    73 APHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLI 137
            .||:|||||:.|..:|:..:|.|.:|||||||||||::|:|::::||::   ||:  ..::..::
Human   161 PPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAIS---GQH--SWIEQQVL 220

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202
            ::..|||.||||||.|||||||||||:||.|:.:....|..|..||||||||.:|...|||:|.|
Human   221 EATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVF 285

  Fly   203 YQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQTIW 264
            |.:|.|.::::.::..| .:...|:||..|   :.:...:..:|....:|.|.|.|:..|...|.
Human   286 YCMLEGMSEDQKKKLGL-GQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEIS 349

  Fly   265 RTIAAVLHLGNVEFQ--TIED----ELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVM 323
            :.:||:|||||::::  |.|:    |::.|  ..|.:.|.||:|...:|.:.||.|.:...|..:
Human   350 KLLAAILHLGNLQYEARTFENLDACEVLFS--PSLATAASLLEVNPPDLMSCLTSRTLITRGETV 412

  Fly   324 QKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSN 388
            ....:..||...:||..|.||.|||.||:.:||.||....|:........||:|||:|||.|..|
Human   413 STPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVN 477

  Fly   389 SFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDE 453
            ||||.|||:.||.|||.|:..|.|.|||||..|.|:|.:||:.:|:...|::......||:::||
Human   478 SFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDE 542

  Fly   454 ACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKN 518
            .. ...|.||.|:|..::.....:.:|    :.|.:   .|...|.|.|:||.|.|...||:|||
Human   543 ES-KFPKGTDTTMLHKLNSQHKLNANY----IPPKN---NHETQFGINHFAGIVYYETQGFLEKN 599

  Fly   519 KDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVR 583
            :|||:.|..:|:|:|::..:.:::........:|.||..|..:.|:||:..|:.||...:||:||
Human   600 RDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVR 664

  Fly   584 CIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAG 648
            |||||:.|...:||......|:||.|::|.:|:||||:..|..:.:|:.||:::.....|.::.|
Human   665 CIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQG 729

  Fly   649 SDRDGVRVLIEEKKFA-QDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRN 712
            ..|...:.:.|..... .|.:.|.||||::....:. ||.:|::.|...|.||||.:||:..|.|
Human   730 DLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDML-LEVERDKAITDRVILLQKVIRGFKDRSN 793

  Fly   713 FKKMKAAITIV-RAYKAYKLR-SY---------VQELANRLRKAKQMRDYGKSIQWPQPPLAGRK 766
            |.|:|.|.|:: |.::.:..| :|         :|.| :|.||..|           |..||.::
Human   794 FLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQAL-HRSRKLHQ-----------QYRLARQR 846

  Fly   767 V---EAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGR 808
            :   :|:.       ||.::...:....|..|.:|..|...:|.|
Human   847 IIQFQARC-------RAYLVRKAFRHRLWAVLTVQAYARGMIARR 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	260/691 (38%)
		MYSc_Myo1	21..677	CDD:276829	254/665 (38%)
		Myosin_TH1	801..983	CDD:283635	3/8 (38%)
MYO7A	XP_011543348.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910