DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo31DF and MYO6

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001355794.1	Gene:	MYO6 / 4646	HGNCID:	7605	Length:	1294	Species:	Homo sapiens

Alignment Length:	798	Identity:	267/798 - (33%)
Similarity:	425/798 - (53%)	Gaps:	88/798 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQM-NIYGPETIRKYKGRELFEN 72
            |:|...|..::....:.|::.|:....||||:..:.:::|||..: .||..|.|:.|:|:.|...
Human    59 VEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTR 123

  Fly    73 APHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLI 137
            .||:|||||.|:|.:|..:....|::||||||||||.:|.:::|:.. :...||:..:|:    :
Human   124 PPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTE-SYGTGQDIDDRI----V 183

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202
            ::|.:||.||||||.||:|||||||:::|.|:.|:..|||.:::|||||||:..|...|||:|.|
Human   184 EANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIF 248

  Fly   203 YQLLRGANDNELRQ-------------------YELQKETGKY--------HYLNQGSM--DILT 238
            |:|..||:: ::|:                   |...|||.|.        .||..|||  .:|.
Human   249 YRLCAGASE-DIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLD 312

  Fly   239 EKSDYKGTCNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQ---TIEDELVISNK--QHLKSTAK 298
            :..|:...|.|.|.:|...:|...::|.:|.||||||::|:   :......:.||  |.|:..|:
Human   313 DHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAQSLEYCAE 377

  Fly   299 LLQVTETELSTALTKRVI---AAG--GNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRA 358
            ||.:.:.:|..:||.||:   |.|  |.|::......||...:|||||.:|..||..:::|:|:.
Human   378 LLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQC 442

  Fly   359 ILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGI 423
            ..|   :|.:.|   ||||||.|||.|:.|||||||||||||||||.|.|.:||:|||.||:||:
Human   443 FPF---ETSSYF---IGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGL 501

  Fly   424 EWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLS-----KHPHYTSR 483
            ....:.|.:|:...||:|....||:.|:||         ::.|....|::.:     ||..:...
Human   502 GVNEVHYVDNQDCIDLIEAKLVGILDILDE---------ENRLPQPSDQHFTSAVHQKHKDHFRL 557

  Fly   484 QLKPTDKELKHR-----EDFRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWP 543
            .:....|...||     |.|.|.|:||.|.|....|:|||.|.|:...:.|:..|:|..:.|::.
Human   558 TIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFE 622

  Fly   544 EGAQDIKKTTKRP-----LTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEH 603
            ....:.|.|.::.     ::.|..|:..:..|:..|......::||||||...:|..|:..::..
Human   623 SSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILS 687

  Fly   604 QVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSD-RDGVRVLIEEKKFAQ-D 666
            |::..|::..|.:.:.|:..|..:.:.   |.|..:| .|:..|..| |...:.|.:.....: |
Human   688 QLQCSGMVSVLDLMQGGYPSRASFHEL---YNMYKKY-MPDKLARLDPRLFCKALFKALGLNEND 748

  Fly   667 VKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMK-AAITIVRAYKAYK 730
            .|:|.||:|.|..:  ||...|..:..|..:..|.|||..|:....:||:: .::::::.....|
Human   749 YKFGLTKVFFRPGK--FAEFDQIMKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIK 811

  Fly   731 LRSYVQELANRLRKAKQM 748
            .|:   |...:::|..:|
Human   812 YRA---EACIKMQKTIRM 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	254/737 (34%)
		MYSc_Myo1	21..677	CDD:276829	247/712 (35%)
		Myosin_TH1	801..983	CDD:283635
MYO6	NP_001355794.1	MYSc_Myo6	71..759	CDD:276833	247/712 (35%)
		Responsible for slow ATPase activity. /evidence=ECO:0000250\|UniProtKB:Q29122	273..317		11/43 (26%)
		Actin-binding. /evidence=ECO:0000255	665..672		4/6 (67%)
		Required for binding calmodulin. /evidence=ECO:0000250\|UniProtKB:Q29122	782..810		6/27 (22%)
		SMC_prok_B	<800..>1039	CDD:274008	5/30 (17%)
		Three-helix bundle. /evidence=ECO:0000250\|UniProtKB:Q29122	835..916
		SAH. /evidence=ECO:0000269\|PubMed:18511944	917..984
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	934..955
		Interaction with OPTN. /evidence=ECO:0000250\|UniProtKB:Q9I8D1	1116..1118
		Myosin-VI_CBD	1177..1267	CDD:339762
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920