Protein Alignment Myo31DF and MYO5B

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_001073936.1
• Gene: MYO5B / 4645
• HGNCID: 7603
• Length: 1848
• Species: Homo sapiens
• Alignment Length: 1055
• Identity: 326/1055 - (30%)
• Similarity: 503/1055 - (47%)
• Gaps: 165/1055 - (15%)

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRF-QNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71
            |..|...|..:.....:.||:.|| ::..||||.|.|.|::|||.|:.|||.:.|..|.|:.:.:
Human    70 GENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGD 134

  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVL 136
            ..||:||:|:.||:.:.:.:::..|::|||||||||.::|..|:|.|.|..:..:..||   ..:
Human   135 MDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIE---EKV 196

  Fly   137 IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHS 201
            :.|:.|:|..|||||.|||||||||||:.|.||.:...:|..:..|||||||||.|...|||:|.
Human   197 LASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHI 261

  Fly   202 FYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQTI 263
            ||||...|...|.::..| .....:.|.:||   |::.:.:..|::.|..||..||.......:|
Human   262 FYQLCAAAGLPEFKELAL-TSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSI 325

  Fly   264 WRTIAAVLHLGNVEFQTIE--DELVISNKQ-HLKSTAKLLQVTETELSTALTKRVIAAGGNVMQK 325
            ::.||::||||:|..|...  |...||.:. :|.:..:||.|..:::...|..|.:........|
Human   326 FKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVK 390

  Fly   326 DHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSF 390
            ..:..|....::||||.||.:||.||:..||:|:     .|..:.:|.||||||||||.|:.|||
Human   391 TMSLQQVINARNALAKHIYAQLFGWIVEHINKAL-----HTSLKQHSFIGVLDIYGFETFEVNSF 450

  Fly   391 EQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEAC 455
            |||||||.||||||.|...|.|.|||||.:|.|.||.|::::|:...||:| ...||:.::||.|
Human   451 EQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIE-AKLGILDLLDEEC 514

  Fly   456 LSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKD 520
             .|.|.||......:....|...|:...::..|        .|.|.|:|..|.|..:||:|||:|
Human   515 -KVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNT--------AFIIVHFADKVEYLSDGFLEKNRD 570

  Fly   521 TLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTT-------------KRP----------LTAGTL 562
            |:|::...:|..||...:::::.:....:..||             .||          .|.|..
Human   571 TVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQ 635

  Fly   563 FQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRY 627
            |:.|:..|:.||....|.|||||||||.|....||.:|...|:|..|:||.:|:..||:..|..|
Human   636 FRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAY 700

  Fly   628 DKFLLRYKMISQYTWPNFRAGSDRDGV-RVLIEEK-KFAQDVKYGHTKIFIRSPRTLFALEHQRN 690
            ..|..||:::.:   ....|.:|:..: |.::|.. |.....::|.||||.|:.:..: ||..|.
Human   701 HDFFNRYRVLVK---KRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAY-LEKLRA 761

  Fly   691 EMIPHIVTLLQKRVRGWIVRRNFKKMK-AAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKS 754
            :.......::||.||||:.:..:.::| |.:|:.|..:.:..|    .||..||:.:......|.
Human   762 DKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLAR----RLAEHLRRIRAAVVLQKH 822

  Fly   755 IQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWV 819
            .:..:...|.::|.          ||.:::..:.|              |:..||.|    |:.:
Human   823 YRMQRARQAYQRVR----------RAAVVIQAFTR--------------AMFVRRTY----RQVL 859

  Fly   820 GDYLANSQEN--SGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAF----IVS 878
            .::.|.:.:.  .|:.|        |.|      ||::..::.|.:......:|.|..    |.:
Human   860 MEHKATTIQKHVRGWMA--------RRH------FQRLRDAAIVIQCAFRMLKARRELKALRIEA 910

  Fly   879 DSTIH-----------------KLDGIKNKFKDMKRTIKI-------------RELTSISVSPGR 913
            .|..|                 |:|....:||.:...:.:             :||.....|||.
Human   911 RSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGE 975

  Fly   914 D--------------QLIVFHS---------SKNKD----LVFSLESEYTPLKEDRIGEVVGIVC 951
            |              :|...||         |:.||    .|..||.|...||:::......|:|
Human   976 DTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILC 1040

  Fly   952 KKYHDLTGTELRVNV 966
            :...:.....::.|:
Human  1041 QSKDEFAQNSVKENL 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	255/687 (37%)
		Myosin_TH1	801..977	CDD:461801	43/229 (19%)
MYO5B	NP_001073936.1	Requires for interaction with LIMA1. /evidence=ECO:0000269|PubMed:29880681	21..40
		MYSc_Myo5	83..749	CDD:276831	255/687 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..630		4/33 (12%)
		Actin-binding. /evidence=ECO:0000255	640..662		11/21 (52%)
		IQ	811..833	CDD:197470	3/21 (14%)
		IQ	860..881	CDD:197470	5/34 (15%)
		SMC_prok_B	897..>1463	CDD:274008	30/159 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1093..1123
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1166..1192
		Myo5b_CBD	1474..1845	CDD:271261