Protein Alignment Myo31DF and MYO5A

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_001369277.1
• Gene: MYO5A / 4644
• HGNCID: 7602
• Length: 1904
• Species: Homo sapiens
• Alignment Length: 1033
• Identity: 330/1033 - (31%)
• Similarity: 498/1033 - (48%)
• Gaps: 203/1033 - (19%)

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRFQNGS-IYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71
            |..|...|..:.....:.|||.||.:.. ||||.|.|.|::|||.|:.|||.:.|..|.|:.:.:
Human    94 GENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGD 158

  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVL 136
            ..||:||:|:.||:.:.:.:::..|::|||||||||.::|..|:|.|.|:.:..:..:|   ..:
Human   159 MDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVE---EKV 220

  Fly   137 IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHS 201
            :.||.|:|:.|||||.|||||||||||::|.||.:...:|..:..|||||||||.|...|||:|.
Human   221 LASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHI 285

  Fly   202 FYQLLRGANDNELRQYELQKETGKYHYLNQGSMDILTEKSDYK---GTCNAFKTLGFSTDEVQTI 263
            ||||...|...|.:...| .....::|..||...::....|.|   .|..|...||.|......|
Human   286 FYQLCASAKLPEFKMLRL-GNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGI 349

  Fly   264 WRTIAAVLHLGNVEFQTIE-DELVISNK-QHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQKD 326
            :|.:|.:||||||.|.:.: |...|..| :.|....:|:.|...|:...|..|.:|.......|.
Human   350 FRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIFCELMGVDYEEMCHWLCHRKLATATETYIKP 414

  Fly   327 HNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFE 391
            .:..||...:|||||.||.:||.||:..:|:|:     .:..:.:|.||||||||||.|:.||||
Human   415 ISKLQATNARDALAKHIYAKLFNWIVDNVNQAL-----HSAVKQHSFIGVLDIYGFETFEINSFE 474

  Fly   392 QFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACL 456
            ||||||.||||||.|...|.|.|||||.:|.|.||.|::::|:...:|:|. ..||:.::||.|
Human   475 QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIES-KLGILDLLDEEC- 537

  Fly   457 SVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKD 520
            .:.|.||||....: :.:|:|...:...:|.        .:.|.|.|:|..|.|...||:|||||
Human   538 KMPKGTDDTWAQKLYNTHLNKCALFEKPRLS--------NKAFIIQHFADKVEYQCEGFLEKNKD 594

  Fly   521 TLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTT-----KRPL---------------------TA 559
            |::::..::|.:||...|.|::.:..:.|..|:     :.||                     |.
Human   595 TVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTV 659

  Fly   560 GTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHR 624
            |..|:.|:..|:.||....|.|||||||||.|....|||:|...|:|..|:||.:|:..|||..|
Human   660 GHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSR 724

  Fly   625 QRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDV-----------KYGHTKIFIRS 678
            ..|.:|..||:::.:          .:|   ||.:.|:..::|           ::|.||||.|:
Human   725 WTYQEFFSRYRVLMK----------QKD---VLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRA 776

  Fly   679 PRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKM-KAAITIVRAYKAYKLRSYVQELANRL 742
            .:..: ||..|.:.:......:||.:|||::|:.:.:| |||||:.|..:.|:.|.|    |..|
Human   777 GQVAY-LEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCY----AKFL 836

  Fly   743 RKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAG 807
            |:.|......|                       :||..::..:|      ::|.   |||.:
Human   837 RRTKAATIIQK-----------------------YWRMYVVRRRY------KIRR---AATIV-- 867

  Fly   808 RRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKF---NHFNK 869
                       :..||      .|:.|.|...|.:|.|.|       |:....|:.:   .|: |
Human   868 -----------LQSYL------RGFLARNRYRKILREHKA-------VIIQKRVRGWLARTHY-K 907

  Fly   870 QANRAFI---------VSDSTIHKLD--------------GIKNKFKDMKRTIK---------IR 902
            ::..|.|         ::...:.||.              |::||...::|.:.         :.
Human   908 RSMHAIIYLQCCFRRMMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVE 972

  Fly   903 ELTSISVSPGRDQLIVFHSSKNK---DL----------------VFSLESEYTPLKED 941
            :||::..        :::|...|   ||                |.||:.|...|::|
Human   973 KLTNLEG--------IYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQEEIAKLRKD 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	262/699 (37%)
		Myosin_TH1	801..977	CDD:461801	36/195 (18%)
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	330/1033 (32%)
		MYSc_Myo5	107..775	CDD:276831	262/699 (37%)
		Myo5a_CBD	1530..1904	CDD:271262