DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYH8

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_002463.2	Gene:	MYH8 / 4626	HGNCID:	7578	Length:	1937	Species:	Homo sapiens

Alignment Length:	1029	Identity:	306/1029 - (29%)
Similarity:	496/1029 - (48%)	Gaps:	149/1029 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..::..:.....:.||::|:....||||.|..||::|||:.:.:|.||.:..|:|::..|..
Human    90 IEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAP 154

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIA--AVTNAQGQNEIERVKNVL 136
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|  |||..:.::|..:::..|
Human   155 PHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKDESGKMQGTL 219

  Fly   137 ----IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGER 197
                |.:|.:||.||||||.||||||||||::.|.|..........|..||||||||..|...||
Human   220 EDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAER 284

  Fly   198 NFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFSTDEV 260
            ::|.|||:......:.:....:......|.:::||.:.:  :.::.:...|.:|...|||:.:|.
Human   285 SYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILGFTPEEK 349

  Fly   261 QTIWRTIAAVLHLGNVEF-------QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA 318
            .:|::...||:|.||::|       |...|...:::|     .|.|..:...:|..||....:..
Human   350 VSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADK-----AAYLQSLNSADLLKALCYPRVKV 409

  Fly   319 GGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFE 383
            |...:.|.....|......|||||:|:::|.|:::|||:.:     .|:......||||||.|||
Human   410 GNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQL-----DTKQPRQYFIGVLDIAGFE 469

  Fly   384 IFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHKGI 447
            |||.||.||.|||:.||||||.|...:...|||||::||||||.|::..:...| :|:|:| .||
Human   470 IFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKP-LGI 533

  Fly   448 IAIMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNI 511
            .:|::|.|: ..|.||.:....: |::|.|..::.    ||...:.|....|.:.||||.|.|||
Human   534 FSILEEECM-FPKATDTSFKNKLYDQHLGKSANFQ----KPKVVKGKAEAHFSLIHYAGTVDYNI 593

  Fly   512 NGFIEKNKDTLYQDFKRLLHNSKDANLSEMW-----PEGAQDIKKTTKRP----LTAGTLFQRSM 567
            .|:::||||.|......|...|....|:.::     .|.....||..|:.    .|...||:.::
Human   594 TGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADSSAKKGAKKKGSSFQTVSALFRENL 658

  Fly   568 ADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLL 632
            ..|:..|....|.:||||.||:.|:....:.|.|.||:|..|:||.:|:.|.||..|..|..|..
Human   659 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQ 723

  Fly   633 RYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDV-----------KYGHTKIFIRSPRTLFALE 686
            |||:::....|..:          .|:.||.::.:           |:||||:|.:: ..|..||
Human   724 RYKVLNASAIPEGQ----------FIDSKKASEKLLASIDIDHTQYKFGHTKVFFKA-GLLGLLE 777

  Fly   687 HQRNEMIPHIVTLLQKRVRGWIVRRNFKKM----KAAITI---VRAYKA------YKLRSYVQEL 738
            ..|:|.:..|:|..|...||:::|..::||    :|...|   |||:..      .||...::.|
Human   778 EMRDEKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPL 842

  Fly   739 ANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAAT 803
            .......|:|....:..|..:..||  |.|||...:    ...|:.....:::   |:||:.:.
Human   843 LKSAETEKEMATMKEEFQKTKDELA--KSEAKRKEL----EEKMVTLLKEKND---LQLQVQSE- 897

  Fly   804 ALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFN 868
                            .|.||:::|..     ...|||            ::...:.:|:   ..
Human   898 ----------------ADSLADAEERC-----EQLIKN------------KIQLEAKIKE---VT 926

  Fly   869 KQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSKNK-------- 925
            ::|.....::.....|...::::..::|:.|...|||...|...:      |:::||
Human   927 ERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK------HATENKVKNLTEEM 985

  Fly   926 ----DLVFSLESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLD 975
                :.:..|..|...|:|..        .:...||...|.:||:.|....:|:
Human   986 AGLDETIAKLSKEKKALQETH--------QQTLDDLQAEEDKVNILTKAKTKLE 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	245/717 (34%)
		MYSc_Myo1	21..677	CDD:276829	241/692 (35%)
		Myosin_TH1	801..983	CDD:283635	30/187 (16%)
MYH8	NP_002463.2	Myosin_N	38..75	CDD:280832
		Myosin_head	90..769	CDD:278492	242/704 (34%)
		MYSc_Myh8	102..769	CDD:276882	241/692 (35%)
		Actin-binding	658..680		8/21 (38%)
		Actin-binding	760..774		6/14 (43%)
		Myosin_tail_1	849..1926	CDD:279860	43/243 (18%)
		eIF-4B	<1042..1099	CDD:283846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1146
		COG6	1375..>1510	CDD:303003
		DUF342	<1505..1581	CDD:302792
		TMPIT	1741..>1828	CDD:285135
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910