DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYH7

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_000248.2	Gene:	MYH7 / 4625	HGNCID:	7577	Length:	1935	Species:	Homo sapiens

Alignment Length:	1060	Identity:	322/1060 - (30%)
Similarity:	516/1060 - (48%)	Gaps:	154/1060 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..:|..:.....:.||:.|:.:..||||.|..||::|||:.:.:|.||.:..|:|::..|..
Human    87 IEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAP 151

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVT---------NAQGQNEI 129
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|.:.         .:.|:..:
Human   152 PHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTL 216

  Fly   130 ERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQP 194
            |   :.:||:|..||.||||||.||||||||||::.|.|..........|..||||||||:.|..
Human   217 E---DQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLK 278

  Fly   195 GERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFST 257
            .||::|.|||:|.......|....:......|.:::||...:  :.:..:...|.|||..|||::
Human   279 AERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVLGFTS 343

  Fly   258 DEVQTIWRTIAAVLHLGNVEF--QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGG 320
            :|..::::...|::|.||::|  :..|::......:....:|.|:.:...:|...|....:..|.
Human   344 EEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGN 408

  Fly   321 NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIF 385
            ..:.|..|..|..|...|||||:|:|:|.|:::|||..:     :|:......||||||.|||||
Human   409 EYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL-----ETKQPRQYFIGVLDIAGFEIF 468

  Fly   386 DSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHKGIIA 449
            |.|||||.|||:.||||||.|...:...|||||::||||||.|::..:...| ||:|:| .||::
Human   469 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKP-MGIMS 532

  Fly   450 IMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNING 513
            |::|.|: ..|.||.|....: |.:|.|..::.    ||.:.:.|....|.:.||||.|.|||.|
Human   533 ILEEECM-FPKATDMTFKAKLFDNHLGKSANFQ----KPRNIKGKPEAHFSLIHYAGIVDYNIIG 592

  Fly   514 FIEKNKDTLYQDFKRLLHNSKDANLSEMW----------PEGAQDIKKTTKRPLTAGTLFQRSMA 568
            :::||||.|.:....|...|....||.::          .:|....||.:... |...|.:.::.
Human   593 WLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQ-TVSALHRENLN 656

  Fly   569 DLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLR 633
            .|:..|....|.:||||.||:.||..|.|...|.||:|..|:||.:|:.|.||.:|..|..|..|
Human   657 KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 721

  Fly   634 YKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTLFALEHQRNEMIPHIV 697
            |::::....|..:....|.|...|:.......: .|:||||:|.:: ..|..||..|:|.:..|:
Human   722 YRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKA-GLLGLLEEMRDERLSRII 785

  Fly   698 TLLQKRVRGWIVRRNFKKM----KAAITI---VRAYKAYK----LRSY--VQELANRLRKAKQM- 748
            |.:|.:.||.:.|..:||:    .:.:.|   :||:...|    ::.|  ::.|.....:.|:|
Human   786 TRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMA 850

  Fly   749 ---RDYGKSIQWPQPPLAGRK-VEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRR 809
               .::.:..:..:...|.|| :|.|:..:.              .|...|:||:
Human   851 SMKEEFTRLKEALEKSEARRKELEEKMVSLL--------------QEKNDLQLQV---------- 891

  Fly   810 PYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFN---HFNKQA 871
                ||.:   |.||:::|..     :..|||            ::...:.||:.|   ...::.
Human   892 ----QAEQ---DNLADAEERC-----DQLIKN------------KIQLEAKVKEMNERLEDEEEM 932

  Fly   872 NRAFIVSDSTIHKLDGIKNKFKD----MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLE 932
            |.          :|...|.|.:|    :||.|...|||...|...:      |:::||  |.:|.
Human   933 NA----------ELTAKKRKLEDECSELKRDIDDLELTLAKVEKEK------HATENK--VKNLT 979

  Fly   933 SEYTPLKEDRIGEVVGIVCKK-----------YHDLTGTELRVNVTTNISCRLDGKARII--TVE 984
            .|...|     .|::..:.|:           ..||...|.:||..|....:|:.:...:  ::|
Human   980 EEMAGL-----DEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLE 1039

  Fly   985 AASNVEVPNFRPK---EGNI 1001
            ....|.:...|.|   ||::
Human  1040 QEKKVRMDLERAKRKLEGDL 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	249/706 (35%)
		MYSc_Myo1	21..677	CDD:276829	244/681 (36%)
		Myosin_TH1	801..983	CDD:283635	40/201 (20%)
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	322/1060 (30%)
		MYSc_Myh7	99..766	CDD:276881	244/681 (36%)
		Actin-binding	655..677		8/21 (38%)
		Actin-binding	757..771		6/14 (43%)
		SMC_prok_B	1173..1930	CDD:274008
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1907..1935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910