DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYH2

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001093582.1	Gene:	MYH2 / 4620	HGNCID:	7572	Length:	1941	Species:	Homo sapiens

Alignment Length:	1045	Identity:	310/1045 - (29%)
Similarity:	497/1045 - (47%)	Gaps:	176/1045 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..::..:.....:.||::|:....||||.|..||::|||:.:.:|.||.:..|:|::..|..
Human    88 IEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAP 152

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIA--AVTNAQGQNEIE------ 130
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|  |||..:.:.||.
Human   153 PHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQG 217

  Fly   131 RVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPG 195
            .:::.:|.:|.:||.||||||.||||||||||::.|.|..........|..|||||||||.|...
Human   218 TLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVFQLKA 282

  Fly   196 ERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFSTD 258
            ||::|.|||:........:....:......|.:::||.:.:  :.::.:...|.:|...|||:.:
Human   283 ERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILGFTNE 347

  Fly   259 EVQTIWRTIAAVLHLGNVEF-------QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVI 316
            |..:|::...||:|.||::|       |...|...:::|     .|.|..:...:|..||....:
Human   348 EKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADK-----AAYLQSLNSADLLKALCYPRV 407

  Fly   317 AAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYG 381
            ..|...:.|.....|......|||||:|:::|.|:::|||:.:     .|:......||||||.|
Human   408 KVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQL-----DTKQPRQYFIGVLDIAG 467

  Fly   382 FEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHK 445
            |||||.||.||.|||:.||||||.|...:...|||||::||||||.|::..:...| :|:|:| .
Human   468 FEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKP-M 531

  Fly   446 GIIAIMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIY 509
            ||.:|::|.|: ..|.||.:....: |::|.|..::.    ||...:.|....|.:.||||.|.|
Human   532 GIFSILEEECM-FPKATDTSFKNKLYDQHLGKSANFQ----KPKVVKGKAEAHFALIHYAGVVDY 591

  Fly   510 NINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQ---------DIKKTTKRP----LTAGT 561
            ||.|::|||||.|.:....|...|....|:::: .|||         ..||..|:.    .|...
Human   592 NITGWLEKNKDPLNETVVGLYQKSAMKTLAQLF-SGAQTAEGEGAGGGAKKGGKKKGSSFQTVSA 655

  Fly   562 LFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQR 626
            ||:.::..|:..|....|.:||||.||:.|:....:.|.|.||:|..|:||.:|:.|.||..|..
Human   656 LFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRIL 720

  Fly   627 YDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDV-----------KYGHTKIFIRSPR 680
            |..|..|||:::....|..:          .|:.||.::.:           |:||||:|.:: .
Human   721 YADFKQRYKVLNASAIPEGQ----------FIDSKKASEKLLASIDIDHTQYKFGHTKVFFKA-G 774

  Fly   681 TLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKM---KAAITIVRAYKAYKLRSY-------- 734
            .|..||..|::.:..::|..|.|.||::.|..:::|   :.||..::    |.:||:
Human   775 LLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQ----YNIRSFMNVKHWPW 835

  Fly   735 ------VQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWP 793
                  ::.|.......|:|....:..|..:..||  |.|||...:    ...|:.....:::
Human   836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELA--KSEAKRKEL----EEKMVTLLKEKND-- 892

  Fly   794 QLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSG--------YEAYNGSIKNIRNHPADGE 850
             |:||:.|.                 .:.||:::|...        .||   .||.:.....|.|
Human   893 -LQLQVQAE-----------------AEGLADAEERCDQLIKTKIQLEA---KIKEVTERAEDEE 936

  Fly   851 TFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQ 915
            .....|.:                         |...::::..::|:.|...|||...|...:
Human   937 EINAELTA-------------------------KKRKLEDECSELKKDIDDLELTLAKVEKEK-- 974

  Fly   916 LIVFHSSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKK----------YHDLTGTELRVNVTTNI 970
                |:::||  |.:|..|...|.|    .:..:..:|          ..||...|.:||..|..
Human   975 ----HATENK--VKNLTEEMAGLDE----TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029

  Fly   971 SCRLD 975
            ..:|:
Human  1030 KIKLE 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	249/723 (34%)
		MYSc_Myo1	21..677	CDD:276829	245/698 (35%)
		Myosin_TH1	801..983	CDD:283635	34/193 (18%)
MYH2	NP_001093582.1	Myosin_N	36..73	CDD:280832
		Myosin_head	88..772	CDD:278492	246/710 (35%)
		MYSc_Myh2_mammals	100..772	CDD:276877	245/698 (35%)
		Actin-binding. /evidence=ECO:0000250	661..683		8/21 (38%)
		Actin-binding. /evidence=ECO:0000250	763..777		6/14 (43%)
		Myosin_tail_1	852..1929	CDD:279860	47/249 (19%)
		RILP-like	967..1100	CDD:304877	17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1155..1174
		DUF342	<1672..1769	CDD:302792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910