DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYH1

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_005954.3	Gene:	MYH1 / 4619	HGNCID:	7567	Length:	1939	Species:	Homo sapiens

Alignment Length:	1038	Identity:	306/1038 - (29%)
Similarity:	496/1038 - (47%)	Gaps:	164/1038 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..::..:.....:.||::|:....||||.|..||::|||:.:.:|..|.:..|:|::..|..
Human    88 IEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAP 152

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIA--AVTNAQGQNEIE------ 130
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|  |||..:.:.|:.
Human   153 PHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEVTSGKMQG 217

  Fly   131 RVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPG 195
            .:::.:|.:|.:||.||||||.||||||||||::.|.|..........|..||||||||..|...
Human   218 TLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKA 282

  Fly   196 ERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFSTD 258
            ||::|.|||::.....:.:....:......|.:::||.:.:  :.::.:...|.:|.:.|||::|
Human   283 ERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIEILGFTSD 347

  Fly   259 EVQTIWRTIAAVLHLGNVEF-------QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVI 316
            |..:|::...||:|.||::|       |...|...:::|     .|.|..:...:|..||....:
Human   348 ERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADK-----AAYLQNLNSADLLKALCYPRV 407

  Fly   317 AAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYG 381
            ..|...:.|.....|......|||||:||::|.|:::|||:.:     .|:......||||||.|
Human   408 KVGNEYVTKGQTVQQVYNAVGALAKAVYDKMFLWMVTRINQQL-----DTKQPRQYFIGVLDIAG 467

  Fly   382 FEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHK 445
            |||||.||.||.|||:.||||||.|...:...|||||::||||||.|::..:...| :|:|:| .
Human   468 FEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKP-M 531

  Fly   446 GIIAIMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIY 509
            ||.:|::|.|: ..|.||.:....: :::|.|..::.    ||...:.|....|.:.||||.|.|
Human   532 GIFSILEEECM-FPKATDTSFKNKLYEQHLGKSNNFQ----KPKPAKGKPEAHFSLIHYAGTVDY 591

  Fly   510 NINGFIEKNKDTLYQDFKRLLHNSKDANLSEMW----------PEGAQDIKKTTKRPLTAGTLFQ 564
            ||.|:::||||.|.:....|...|....|:.::          ..|.:..||......|...||:
Human   592 NIAGWLDKNKDPLNETVVGLYQKSAMKTLALLFVGATGAEAEAGGGKKGGKKKGSSFQTVSALFR 656

  Fly   565 RSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDK 629
            .::..|:..|....|.:||||.||:.|:....:.|.|.||:|..|:||.:|:.|.||..|..|..
Human   657 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYAD 721

  Fly   630 FLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDV-----------KYGHTKIFIRSPRTLF 683
            |..|||:::....|..:          .|:.||.::.:           |:||||:|.:: ..|.
Human   722 FKQRYKVLNASAIPEGQ----------FIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKA-GLLG 775

  Fly   684 ALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKM----KAAITI---VRAYKAYK----LRSY--V 735
            .||..|:|.:..::|..|...||::.|..::||    ::...|   |||:...|    ::.|  :
Human   776 LLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKI 840

  Fly   736 QELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQII 800
            :.|.......|:|.:..:..:..:..||  |.|||...:    ...|:.....:::   |:||:.
Human   841 KPLLKSAETEKEMANMKEEFEKTKEELA--KTEAKRKEL----EEKMVTLMQEKND---LQLQVQ 896

  Fly   801 AATALAGRRPYWGQARRWVGDYLANSQENSG--------YEAYNGSIKNIRNHPADGETFQQVLF 857
            |.                 .|.||:::|...        .||   .||.:.....|.|.....|.
Human   897 AE-----------------ADSLADAEERCDQLIKTKIQLEA---KIKEVTERAEDEEEINAELT 941

  Fly   858 SSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSS 922
            :                         |...::::..::|:.|...|||...|...:      |::
Human   942 A-------------------------KKRKLEDECSELKKDIDDLELTLAKVEKEK------HAT 975

  Fly   923 KNKDLVFSLESEYTPLKEDRIGEVVGIVCKK----------YHDLTGTELRVNVTTNISCRLD 975
            :||  |.:|..|...|.|    .:..:..:|          ..||...|.:||..|....:|:
Human   976 ENK--VKNLTEEMAGLDE----TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	243/720 (34%)
		MYSc_Myo1	21..677	CDD:276829	239/695 (34%)
		Myosin_TH1	801..983	CDD:283635	35/193 (18%)
MYH1	NP_005954.3	Myosin_N	36..73	CDD:280832
		Myosin_head	88..770	CDD:278492	240/707 (34%)
		MYSc_Myh1_mammals	100..770	CDD:276875	239/695 (34%)
		Actin-binding. /evidence=ECO:0000250	659..681		8/21 (38%)
		Actin-binding. /evidence=ECO:0000250	761..775		6/14 (43%)
		Myosin_tail_1	850..1927	CDD:279860	47/249 (19%)
		RILP-like	965..1098	CDD:304877	17/80 (21%)
		MIT_CorA-like	<1299..>1411	CDD:294313
		DUF342	<1506..1582	CDD:302792
		DUF342	<1670..1767	CDD:302792
		TMPIT	1744..>1853	CDD:285135
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910