DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and MYO1F

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_011526326.1	Gene:	MYO1F / 4542	HGNCID:	7600	Length:	1119	Species:	Homo sapiens

Alignment Length:	1032	Identity:	342/1032 - (33%)
Similarity:	509/1032 - (49%)	Gaps:	186/1032 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            :::||.|.|||.|::.:....||||||.:..|:||||.|.:|:||::||..:....|..|:|...
Human    15 KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQ 79

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            :||.||::|:.|:.||.:....::.|::||||||||||.|:|.||.||:.|:.  |..:::.||:
Human    80 YENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSG--GGEKVQHVKD 142

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
            :::|||.:||.||||||.||:||||||||.:|:|....:|.||.|:|:||||||||.|...||||
Human   143 IILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNF 207

  Fly   200 HSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQ 261
            |.:||||.||:..:.:...|. ....|:||||.   .:|...::||:..|.:|.:.:|......|
Human   208 HIYYQLLEGASQEQRQNLGLM-TPDYYYYLNQSDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQ 271

  Fly   262 TIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA--GG---- 320
            .:.:.:|.:|||||:.|....:...:.:...|...|.||.:....|...||.|.:.:  ||
Human   272 LVLQLVAGILHLGNISFCEDGNYARVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSES 336

  Fly   321 -NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEI 384
             ||..   |..||.|.:|||||.:|.|||.:::..||||:    .|.|..::  |||||||||||
Human   337 INVTL---NVEQAAYTRDALAKGLYARLFDFLVEAINRAM----QKPQEEYS--IGVLDIYGFEI 392

  Fly   385 FDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQ--PHKGI 447
            |..|.|||||||:.||||||:||||.||.|||||.:|||.||.|:|||||::|||:|.  ...||
Human   393 FQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGI 457

  Fly   448 IAIMDEACLSV---GKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIY 509
            ::::|:.|.::   |...|.|||..:...:..|.|:.|           ....|.|.||||.|.|
Human   458 MSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNS-----------WSAGFVIHHYAGKVSY 511

  Fly   510 NINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTL 574
            :::||.|:|:|.|:.|...|:..|:.|.|..::||.....||  .||.|||:..::...|||.||
Human   512 DVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDGDKK--GRPSTAGSKIKKQANDLVATL 574

  Fly   575 LKKEPFYVRCIKPNDLKSSTVFDEERV------------EHQVRYLGLLENLRVRRAGFVHRQRY 627
            ::..|.|:||||||:.|....::|.|.            .||.:..|.:........|...|.|.
Human   575 MRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRGDSAYPPHQSQAPGGIPGPEGEHQGAQSRLRL 639

  Fly   628 ---------DKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTL 682
                     :...|||.:::..|||.:| |.:|.||:.|:.......| .:.|.||:|:::|.:|
Human   640 PPPVRQIPAEPSALRYAILTPETWPRWR-GDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESL 703

  Fly   683 FALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQ 747
            |.||..|..........:||..|..:..|.:::|:                  :|.:|.|...|:
Human   704 FLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMR------------------EEASNILLNKKE 750

  Fly   748 MRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYW 812
            .                              |.|.|
Human   751 R------------------------------RRNSI----------------------------- 756

  Fly   813 GQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIV 877
              .|.:||||| ..:|......:.|.             .::|.|:..|.|::...|...|..|:
Human   757 --NRNFVGDYL-GLEERPELRQFLGK-------------RERVDFADSVTKYDRRFKPIKRDLIL 805

  Fly   878 SDSTIHKLDGIKNKFKD----------MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFS-L 931
            :...::.:.  :.|.|.          :|:.:.|:.|..:|:|..:|...:.    .:|...| |
Human   806 TPKCVYVIG--REKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFIL----QEDAADSFL 864

  Fly   932 ESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRL------DGKARIIT 982
            ||.:..       |.|.::||::.:.|...|.:..:..:..|:      .|..|.:|
Human   865 ESVFKT-------EFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVT 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	291/720 (40%)
		MYSc_Myo1	21..677	CDD:276829	279/692 (40%)
		Myosin_TH1	801..983	CDD:283635	38/199 (19%)
MYO1F	XP_011526326.1	MYSc	12..711	CDD:214580	291/721 (40%)
		MYSc_Myo1	31..698	CDD:276829	279/692 (40%)
		Myosin_TH1	738..918	CDD:283635	45/283 (16%)
		SH3_MyoIe_If_like	1066..1118	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2201
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850