Protein Alignment Myo31DF and myo6b

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_001004110.1
• Gene: myo6b / 445472
• ZFINID: ZDB-GENE-030318-3
• Length: 1267
• Species: Danio rerio
• Alignment Length: 1021
• Identity: 304/1021 - (29%)
• Similarity: 477/1021 - (46%)
• Gaps: 221/1021 - (21%)

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQM-NIYGPETIRKYKGRELFEN 72
            |:|...|..::....::|:|.|:....|||::..:.:::|||..: .:|.||:|:.|:||.|...
Zfish    59 VEDNCSLMYLNEATLLNNIRIRYSKDMIYTFVANILIAVNPYFDIPKLYSPESIKSYQGRSLGTL 123

  Fly    73 APHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLI 137
            .||::||||.|||.::..:....|::||||||||||.:|.:::|: ..:...||:..||:    :
Zfish   124 PPHVYAIADKAYRDMRVLKMSQSIIVSGESGAGKTENTKFVLRYL-TTSYGTGQDIDERI----V 183

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202
            ::|.:||.||||||.||:|||||||:::|.|:.|...|||.:::|||||||:..|...|||:|.|
Zfish   184 EANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICMQSQEERNYHIF 248

  Fly   203 YQLLRGANDNELRQYELQKETGKYHYLNQGSM--------------------------------D 235
            |:|..||:: ::|..........:.|||:|..                                .
Zfish   249 YRLCAGASE-DIRNMLHLNSPDSFRYLNRGCTRYFANKDSDKQIMQNXKSPEDHKHGKVGALKDP 312

  Fly   236 ILTEKSDYKGTCNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQ---TIEDELVISNK--QHLKS 295
            :|.:..|:.....|.|.:|....|...::|.:|.||||||::|:   :.....::.|:  |.|:.
Zfish   313 LLDDLGDFNRMVVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEETGSTSGGCILKNQSSQTLEY 377

  Fly   296 TAKLLQVTETELSTALTKRVI-----AAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRI 355
            .|.||.:.:.:|..:||.||:     .|.|.|::......||...:||||||:|.|||..::.|:
Zfish   378 CADLLGLDQDDLRVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKAVYSRLFDHVVKRV 442

  Fly   356 NRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQR 420
            |:...|   .|.:.|   |||.||.|||.|:.|||||||||||||||||.|.|.:||:|||.|||
Zfish   443 NQCFPF---DTSSNF---IGVPDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQR 501

  Fly   421 EGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNL-----SKH-PH 479
            ||:....:.|.:|:...||||....|::.|:||         ::.|....|::.     ||| .|
Zfish   502 EGLGVNEVHYVDNQDCIDLVEAKLVGVLDILDE---------ENRLPQPSDQHFAEAVHSKHKDH 557

  Fly   480 Y---TSRQLKPT-DKELKHREDFRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSE 540
            :   ..|:.|.| .:.|:..|.|.|.|:||.|.|....|:|||.|.|:...:.|:..|||..:.:
Zfish   558 FRLTVPRKSKLTIHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLVCESKDKFVRD 622

  Fly   541 MWPEGAQDIKKTTKRP------LTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEE 599
            ::...:.  .|.:|:.      ::.|..|:..:..|:..|......::||:|||....|..|:..
Zfish   623 LFENNSN--SKDSKQKAGKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCVKPNLKMVSHQFEGA 685

  Fly   600 RVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSD-RDGVRVLIEEKKF 663
            ::..|::..|::..|.:.:.||..|..:.:.   |.|..|| .||.....| |...:.|.:....
Zfish   686 QILSQLQCSGMVSVLDLMQGGFPSRAPFHEL---YNMYKQY-MPNKLTRLDPRLFCKALFKALGL 746

  Fly   664 AQ-DVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMK-AAITIVRAY 726
            .: |.|:|.|::|.|..:  ||...|..:..|..:..|.|||..|:|...:||:: ..::::
Zfish   747 NENDYKFGLTRVFFRPGK--FAEFDQIMKSDPDHLAELVKRVNKWLVCSRWKKVQWCTLSVI--- 806

  Fly   727 KAYKLR---SYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYP 788
               |||   ||......|::|..:|        |    |..|:                  || |
Zfish   807 ---KLRNKMSYRASACIRIQKTVRM--------W----LCRRR------------------HK-P 837

  Fly   789 RSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQ 853
            |.:                     |..:                      :||:|
Zfish   838 RVD---------------------GLVK----------------------VKNLR---------- 849

  Fly   854 QVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIV 918
                    |:...||:..|              |:|....:|.:  :|.||.:     ..|.|:
Zfish   850 --------KRMERFNEAVN--------------GLKEGKAEMSK--QIEELAA-----STDALM- 884

  Fly   919 FHSSKNKDLVFS---LESEYTPLKEDRIGEVVGIVCKKYHDLTGTE 961
               :|.|..|.|   :|.||..|.: |..:::..:.||..:...||
Zfish   885 ---AKIKTTVMSRKEIEQEYEGLVK-RSEQLLSSMQKKKQEQEETE 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	244/716 (34%)
		Myosin_TH1	801..977	CDD:461801	29/164 (18%)
myo6b	NP_001004110.1	Myosin_N	2..>32	CDD:460670
		MYSc_Myo6	71..761	CDD:276833	244/716 (34%)
		CBD_MYO6-like	772..919	CDD:409646	50/270 (19%)
		DUF4670	<872..1032	CDD:464815	18/65 (28%)
		MYO6_MIU_linker	1001..1081	CDD:412090
		MyUb_Myo6	1064..1104	CDD:439319
		Myosin-VI_CBD	1150..1240	CDD:465157