DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo1a

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001074688.1	Gene:	Myo1a / 432516	MGIID:	107732	Length:	1043	Species:	Mus musculus

Alignment Length:	1073	Identity:	421/1073 - (39%)
Similarity:	603/1073 - (56%)	Gaps:	130/1073 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MQREAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGR 67
            ::...||:|.:||:.:..|..:.||:.|::|..||||||.|.:|||||.|:.|||||.|.||:..
Mouse     4 LEGPVGVEDLILLEPLDEESLIKNLQLRYENKEIYTYIGNVVISMNPYEQLPIYGPEFIAKYRDY 68

  Fly    68 ELFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERV 132
            ..:|..||::|:|:.||:.||.|.:|.||||:||||||||||||::|.|:|||. .:|: ::..|
Mouse    69 TFYELKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVC-GKGE-QVNSV 131

  Fly   133 KNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGER 197
            |..|:|||.:||.||||||.||:||||||||||||||:|..|:||:||||||||||||:|..|||
Mouse   132 KEQLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGER 196

  Fly   198 NFHSFYQLLRGANDNELRQYELQKETGKYHYLN--QGSMDILTEKSDYKGTCNAFKTLGFSTDEV 260
            |||.|||||.||:...|:..:|:::|..|.|||  ...::.:.:.|:::...:|...:|||.:|:
Mouse   197 NFHIFYQLLAGADAQLLKALKLEEDTSVYGYLNGEVSKVNGMDDASNFRAVQHAMSVIGFSEEEI 261

  Fly   261 QTIWRTIAAVLHLGNVEFQTIEDELV--------ISNKQHLKSTAKLLQVTETELSTALTKRVIA 317
            :.:....|.||.||||:   :.||..        |.:.:.::...:::.:..|||..||..|.:.
Mouse   262 RQVLEVTALVLKLGNVK---LTDEFQANGIPASGICDGKGIQEIGEMMGLNSTELERALCSRTME 323

  Fly   318 AGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAI-LFRGSKTQARFNSVIGVLDIYG 381
            .|...:....|.|||:|.:|||||.||.|||.||:.|||.:| :..|.|     ..|:|||||||
Mouse   324 TGKEKVVTVLNVTQAQYARDALAKNIYSRLFDWIVKRINESIKVGTGEK-----KKVMGVLDIYG 383

  Fly   382 FEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKG 446
            |||.:.||||||.||||||:|||:||||.||:|||||:||||.||.:|||:|.|||:|:|...:|
Mouse   384 FEILEDNSFEQFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICNLIEHSQRG 448

  Fly   447 IIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHR---EDFRITHYAGDVI 508
            |:|::||.||..|.|:|.|.|..:::..|||.||.|:..:...::....   ..|||:||||.|.
Mouse   449 ILAMLDEECLRPGVVSDSTFLAKLNQLFSKHSHYESKVSQNAQRQYDRTMGLSCFRISHYAGKVT 513

  Fly   509 YNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVT 573
            ||:.|||:||.|.|::|..:.:..::...|..::||| ...:.:.|||.||||.|:.|:|.|:..
Mouse   514 YNVTGFIDKNNDLLFRDLSQTMWKAQHPLLKSLFPEG-NPKEASLKRPPTAGTQFKNSVAVLMKN 577

  Fly   574 LLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMIS 638
            |..|.|.|:|||||||.:....|..|.|..|.||||||||:||||||:..||.|..||.||:::|
Mouse   578 LYSKNPNYIRCIKPNDQQQKGRFTSEMVMVQARYLGLLENVRVRRAGYAFRQGYKPFLERYRLLS 642

  Fly   639 QYTWPNFRAGSDRDGV-RVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQK 702
            :.|||.:. |.||:|| :||......::::.||.||||||||:|||.||.||...:..:.||:||
Mouse   643 RSTWPRWN-GDDREGVEKVLGSLTLSSEELAYGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQK 706

  Fly   703 RVRGWIVRRNFKKMKAAITIVRAY-------KAY-KLRS---YVQELANRLRKAKQMRDYGKS-- 754
            ..|||..|.::::|:.:..::.|:       |.| |:||   .:|......|..|..|.|.:|
Mouse   707 VYRGWRCRTHYQQMRKSQILISAWFRGNKQKKHYGKIRSSVLLIQAFVRGWRARKNYRKYFRSGA 771

  Fly   755 -------------------------------IQWPQPPL-AGRKVEAKLHRMFDFWRANMILHKY 787
                                           ..||..|. .......:|.|:|..|:......:.
Mouse   772 ALTLANFIYQSMAQKFLLNLKKNLPSTKVLDNTWPAAPYRCFNTANQELQRLFYQWKCKKFRDQL 836

  Fly   788 PRSEWPQLRLQIIAATALAGRRPYWGQA--RRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGE 850
            ...:...||.::.|:....|::..:.|:  ..:.|||:       |.:. |..::.::     |.
Mouse   837 SPKQVQTLREKLCASELFKGKKASYPQSVPIPFRGDYI-------GLQG-NPKLQRLK-----GR 888

  Fly   851 TFQQVLFSSFVKKFNHFN-KQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRD 914
            ....||.:..|||.|..| |.:.|..:::...:...|..|::   .:..|.:.::..:|||..:|
Mouse   889 EEGPVLVADTVKKVNRGNGKTSARILLLTKGHVILTDAKKSQ---AQIVIGLEDVAGVSVSSLQD 950

  Fly   915 QLIVFHSSKNKDLV----FSLESEYTPLKEDRIGEVVGIVCKKYH---DLTGTELRVNVTTNISC 972
            .|...|.|:....|    ..|.|::          ||.::.|.|.   |.|..:|.|.||...|.
Mouse   951 GLFSLHLSEMSSAVSKGDILLVSDH----------VVELLTKMYQAVLDATQRQLSVTVTEKFSV 1005

  Fly   973 RLDGKARIITVEAASNVEVPNFRPKEGNIIFEV 1005
            |.                      |||::..:|
Mouse  1006 RF----------------------KEGSVAVKV 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	343/698 (49%)
		MYSc_Myo1	21..677	CDD:276829	328/670 (49%)
		Myosin_TH1	801..983	CDD:283635	43/191 (23%)
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	328/670 (49%)
		Actin-binding. /evidence=ECO:0000255	571..593		11/21 (52%)
		IQ	742..764	CDD:197470	6/21 (29%)
		Myosin_TH1	847..1042	CDD:368706	47/218 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53790
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730