DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo31DF and jar

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster

Alignment Length:	1013	Identity:	305/1013 - (30%)
Similarity:	468/1013 - (46%)	Gaps:	213/1013 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVQD------FVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQM-NIYGPETIRKYK 65
            |.||      .:||::.:   |:|||:.|:....||||:..:.:::||||:: .:|.|:||:||.
  Fly    55 GPQDHDDNCELMLLNEAT---FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYN 116

  Fly    66 GRELFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIE 130
            ||.|.|..||:|||||.|.|.::..:....|::||||||||||::|.::||:....::.|.
  Fly   117 GRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGP---- 177

  Fly   131 RVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPG 195
             ::..::.:|.:||.||||||.||:|||||||::::.:|.|...|||.|::|||||||:..|...
  Fly   178 -IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAE 241

  Fly   196 ERNFHSFYQLLRGANDNELRQYELQKETGKYHYLN---QGSMDILTEK----------------- 240
            |||:|.||.||.|| ..:||......:...|.||:   |...:..||:
  Fly   242 ERNYHVFYMLLAGA-PQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPL 305

  Fly   241 -----SDYKGTCN---AFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQTIED------ELVISNKQ 291
                 .||:...|   |...||.|..|...|:..:||||||||:.|:.|.|      ::..:::|
  Fly   306 KDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQ 370

  Fly   292 HLKSTAKLLQVTETELSTALTKRVIAAGGN--------VMQKDHNATQAEYGKDALAKAIYDRLF 348
            .|..|:.||.|.:|||.|||..||:.:.|.        |..|.:.|:.|   :||||||||.|||
  Fly   371 SLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNA---RDALAKAIYSRLF 432

  Fly   349 TWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQ 413
            ..|:..||::|.|:.|      |..||||||.|||.|..||||||||||||||||:.|.:.:||.
  Fly   433 DRIVGLINQSIPFQAS------NFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKN 491

  Fly   414 EQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSK-- 476
            |||.|:|||:....|.:.:|:.|.:|:|....||..::||                 :..|.|
  Fly   492 EQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDE-----------------ESKLPKPS 539

  Fly   477 HPHYTSRQLK----------PTDKELK-HR-----EDFRITHYAGDVIYNINGFIEKNKDTLYQD 525
            :.|:|:...|          |....|| ||     |.|.:.|:||.|.||...|||||.|.|:..
  Fly   540 YSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHAS 604

  Fly   526 FKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDL 590
            .:.|:....:..|..::|.|:....:.....::.|:.|:..:.:|:..|.:....::||||||..
  Fly   605 LEGLVQECDNPLLQTLFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSK 669

  Fly   591 KSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVR 655
            .....|:......|::..|.:..|.:...|:..|..:......||.:..   |...:...|....
  Fly   670 MIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLP---PELVSLPARTFCE 731

  Fly   656 VLIEEKKF-AQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVR-RNFKKMKA 718
            .:.:.... |:|.|:|.||:|.|..:.:......|::  |..:..:..:|:.|::| |..|....
  Fly   732 AMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSD--PENMLAIVAKVKKWLIRSRWVKSALG 794

  Fly   719 AITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMI 783
            |:.:::             |.||:                                  .:|...:
  Fly   795 ALCVIK-------------LRNRI----------------------------------IYRNKCV 812

  Fly   784 LHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPAD 848
            |                             .|:|....:||..|....|:.. |.|..||.:
  Fly   813 L-----------------------------IAQRIARGFLARKQHRPRYQGI-GKINKIRTN--- 844

  Fly   849 GETFQQVLFSSFVKKFNHFNKQANRAFIVS--DSTIHKLDGIKNKFKDMKRTIKIRELTSISVSP 911
              |.:.:..:|.:|        ..|..|:|  :....::|....|.| |...|..||:.|:
  Fly   845 --TLKTIEIASGLK--------MGREEIISGVNDIYRQIDDAIKKIK-MNPRITQREMDSM---- 894

  Fly   912 GRDQLIVFHSSKNK---DLVFSLESEYTPLKEDRIGEV 946
                ..|..::.||   ||...|:.:....:::|:.::
  Fly   895 ----YTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKI 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	261/749 (35%)
		MYSc_Myo1	21..677	CDD:276829	255/717 (36%)
		Myosin_TH1	801..983	CDD:283635	31/151 (21%)
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	257/732 (35%)
		MYSc_Myo6	71..754	CDD:276833	255/720 (35%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466274
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950