DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and myo1eb

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_956930.1	Gene:	myo1eb / 393609	ZFINID:	ZDB-GENE-040426-1347	Length:	1096	Species:	Danio rerio

Alignment Length:	1047	Identity:	354/1047 - (33%)
Similarity:	553/1047 - (52%)	Gaps:	192/1047 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71
            :||.|.|||.:::.:...|||:||:.:..|:||||.|.:|:||::|:..:....|..|:|...:|
Zfish    17 SGVDDMVLLSKITEDAITDNLKKRYMDDYIFTYIGPVLISVNPFKQLPYFTDREIELYQGAAQYE 81

  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVL 136
            |.||::|:||:.||.:....::.|::||||||||||.|:|.||.||:.|:.  |..:::.||:::
Zfish    82 NPPHIYALADNMYRNMMIDSENQCVIISGESGAGKTVAAKYIMSYISKVSG--GGPKVQHVKDII 144

  Fly   137 IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHS 201
            :|||.:||.||||||.||:||||||||.:|:|....:|.||.|:|:||||||||.|..||||||.
Zfish   145 LQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNNGERNFHI 209

  Fly   202 FYQLLRGANDNELRQYELQKETGKYH-YLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQT 262
            :||||:||. .|.|: .|...|..|: ||||.   :::.:.:|.:::.|.||...:|.|.|...:
Zfish   210 YYQLLKGAT-KEQRE-NLGVTTPDYYFYLNQSDTYTVEDVNDKKEFEDTMNAMSVVGLSMDAQDS 272

  Fly   263 IWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA--GG--NVM 323
            :.:.:|.:|||||:.|:...:..|:.::..|...:.||.:.:..|.:.||.|::.:  ||  ..:
Zfish   273 VLQIVAGILHLGNIAFREEGNYAVVESEDFLAFPSYLLGINQDGLKSKLTSRIMDSKWGGKTETI 337

  Fly   324 QKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSN 388
            ....|..||.:.:|||:||:|.|||.:::..||:|:    .|.:...|  ||||||||||||..|
Zfish   338 SVTLNTEQASFTRDALSKALYSRLFDYLVDAINKAM----QKDREELN--IGVLDIYGFEIFQKN 396

  Fly   389 SFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQP--HKGIIAIM 451
            .|||||||:.||||||:||||.||.|||||.:|||.||.|||||||::|||:|..  ..||::|:
Zfish   397 GFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGISWTPIEYFNNKVVCDLIESKLNPPGIMSIL 461

  Fly   452 DEACLSV---GKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNING 513
            |:.|.::   |:..|.|||..:...:..|.|:.|           ..:.|.:.||||.|.|:::|
Zfish   462 DDVCATMHAKGEGADQTLLQKLQSQIGTHEHFNS-----------WNKGFVVHHYAGKVSYDVSG 515

  Fly   514 FIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKE 578
            |.|:|:|.|:.|...|:.:|:.|.:..::||..:..|:  .||.|||:..::....||.||:|..
Zfish   516 FCERNRDVLFSDIIELMQSSEFAFIKGLFPENIEAEKR--GRPTTAGSKIKKQANTLVQTLMKCT 578

  Fly   579 PFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWP 643
            |.|:||||||:.|.|..::|.||:|||.||||.||:||||||:..|:.:.|||.||.::::.|||
Zfish   579 PHYIRCIKPNETKKSRDWEESRVKHQVEYLGLRENIRVRRAGYAFRRIFKKFLHRYAILTRETWP 643

  Fly   644 NFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGW 707
            .:| |.::.||..|::......| .:.|.|||||::|.:||.||..|.
Zfish   644 QWR-GDEKQGVLHLLKSVNMDSDQYQLGKTKIFIKAPESLFLLEEMRE----------------- 690

  Fly   708 IVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLH 772
                            |.|..|         |..:::|
Zfish   691 ----------------RKYNGY---------ARVIQQA--------------------------- 703

  Fly   773 RMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQA--RRWVGDYLANSQENSGYEAY 835
                 ||.::.:.||       :|::..|:..|..::.....:  |.:||||:...
Zfish   704 -----WRKHIAVRKY-------VRMREEASDLLLNKKERRKNSLNRNFVGDYIGTD--------- 747

  Fly   836 NGSIKNIRNHPADGETF---QQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKD--- 894
                    |||...:..   :::.|:..|.|::...|...|..|::...::.:.  :.|.|.
Zfish   748 --------NHPEIRQFVGRRERIDFADVVVKYDRRFKSVKRDLILTPKFLYLIG--REKVKQGPE 802

  Fly   895 -------MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRIGEVVGIVCK 952
                   :||.|::.::.|:|:|..:|.:.:.|..:...:   |:|.:..       |.:.::.|
Zfish   803 KGQIREVLKRKIEVEKIQSVSLSTLQDDIFILHEDQYDSV---LQSVFKT-------EFLSLLYK 857

  Fly   953 KYHDLTGTELRVNVTTNISCR----------------------------LDGKARIITVEAASNV 989
            ::.:.|..:|.:.....:..:                            |...::|:||...|.:
Zfish   858 RFEEKTKKKLPLKFNNLLEFKVKKGGWGPFASAGSRQIQFQMGQGDDAVLKPSSKILTVSIGSGL 922

  Fly   990 EVPNFRP 996
            . .|.||
Zfish   923 P-KNTRP 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	303/696 (44%)
		MYSc_Myo1	21..677	CDD:276829	291/669 (43%)
		Myosin_TH1	801..983	CDD:283635	34/224 (15%)
myo1eb	NP_956930.1	MYSc	12..690	CDD:214580	303/696 (44%)
		MYSc_Myo1	31..677	CDD:276829	291/669 (43%)
		Myosin_TH1	717..902	CDD:283635	32/213 (15%)
		SH3_MyoIe_If_like	1043..1095	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820