DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and ninaC

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster

Alignment Length:	865	Identity:	219/865 - (25%)
Similarity:	394/865 - (45%)	Gaps:	138/865 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENAP 74
            :|...|:....|..:::||.|...|..|::||::.:|:|.......:..|...||:.:...||.|
  Fly   335 EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQP 399

  Fly    75 HLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAV----TNAQGQNEIERVKNV 135
            |:|::||.||:.:...::...|::||||.:||:..:::::|::..:    ..|.|:.| ..:|.:
  Fly   400 HIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVE-SSIKAI 463

  Fly   136 LIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFH 200
            |:        ..||.|..|::|:|......:.|.......|.:...|:|||.||......:.|||
  Fly   464 LM--------LVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFH 520

  Fly   201 SFYQLLRGAN-DNELRQYELQKETGKYHYLN-----------------QGSMDILTEKSDYKGTC 247
            .||......| .|:|::|.| |....|.||.                 :|:::      .|:...
  Fly   521 IFYYFYDFINQQNQLKEYNL-KADRNYRYLRVPPEVPPSKLKYRRDDPEGNVE------RYREFE 578

  Fly   248 NAFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALT 312
            |..:.:.|:..:::|:.:.:||:|::||:.|:.......:.|...:...|:||:|.|.:...:||
  Fly   579 NILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLT 643

  Fly   313 KRVIAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARF---NSVI 374
            ..::..||...::.:...:|...:||:|..:|.||..:||:|||..:.|    .:|.|   |::|
  Fly   644 NFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSF----PRAVFGDTNAII 704

  Fly   375 GVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICD- 438
             :.|::|||.|:.|..||..||..||::|..:.:.:...|..|.:.|.|:..|:.:::||...|
  Fly   705 -IHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDN 768

  Fly   439 LVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHY 503
            |:.:| .|:..|:|:|..|   ..|..|:  ||:...||..:..   |.|..|:.      :.||
  Fly   769 LLTKP-DGLFYIIDDASRS---CQDQDLI--MDRVSEKHSQFVK---KHTATEIS------VAHY 818

  Fly   504 AGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMW------------PEGAQDIKKTTKR- 555
            .|.:||:...|.:.|:|.:..:......:|.|.::..|:            |..|...|..::|
  Fly   819 TGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERK 883

  Fly   556 -----PLTAGTLFQ----RSMAD----LVVTLLKK-------EPFYVRCIKPNDLKSSTVFDEER 600
                 .|:||.:.|    |::|.    ..:||||.       ...:||||:.:.......|..:.
  Fly   884 SYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDV 948

  Fly   601 VEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMIS-QYTWPNFRAGSDRDGVRVLIEEKKFA 664
            |:.|::.||:|:.:..|:.||..|..:|:||.||:.:: .:..|   ....:|..|:|....|.
  Fly   949 VQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEP---VEMTKDNCRLLFLRLKM- 1009

  Fly   665 QDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRV-------RGWIVRRNFKKMK----- 717
            :....|.||:|:|         :..:|.:..:..|..|:|       |..:.|:..|..|
  Fly  1010 EGWALGKTKVFLR---------YYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLG 1065

  Fly   718 ---------AAITIVRAYKAY----KLRSYVQELANRLRK--AKQMRDYGKSIQWPQPPLAGRKV 767
                     ||..|.:|::.:    :|...|.|.:.:|.:  |..:|.:.|  :|.:..:....:
  Fly  1066 KKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAK--KWREKSIFQVLL 1128

  Fly   768 EAKLHRMFDFWRANMILHKY 787
            ..:..|..||...:..:|.|
  Fly  1129 HYRAARFQDFVNLSQQVHIY 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	194/739 (26%)
		MYSc_Myo1	21..677	CDD:276829	191/715 (27%)
		Myosin_TH1	801..983	CDD:283635
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		S_TKc	16..282	CDD:214567
		MYSc	327..1034	CDD:214580	195/747 (26%)
		MYSc_Myo21	346..1022	CDD:276848	191/715 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910