DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo10A

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster

Alignment Length:	891	Identity:	297/891 - (33%)
Similarity:	437/891 - (49%)	Gaps:	134/891 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQM-NIYGPETIRKYKGRELF 70
            :||:|..|||.:.....:.|||.|:..|.|||:.|.:.:::|||:.. :.||.|..::|.||.|.
  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219

  Fly    71 ENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNV 135
            ...||||||..:|:..|...|   .::||||||:||||::|::|:|:|||....|.......:.:
  Fly   220 SLPPHLFAIGAAAHAALPSPQ---VVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281

  Fly   136 LIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFH 200
            | ::..:||.||||:|.|||||||||||:::.|...| .||..||.|||||||:|.|.|||||:|
  Fly   282 L-EAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGA-IVGAKITQYLLEKSRIVTQAPGERNYH 344

  Fly   201 SFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDILTEKSDYKGTCNAFKTLGFSTDEVQTIWR 265
            .||:||.|.::.|..:|.| .|..||.|||||:.|..:.:.|::....|.:.||.|..|.:.|.|
  Fly   345 VFYELLGGLSETERSKYGL-LEADKYFYLNQGATDCASGRVDWESLQGAMQVLGVSEGEREGIVR 408

  Fly   266 TIAAVLHLGNVEFQTI-----EDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQK 325
            .:|||||||||.|...     ::.:.:.:...:|..|.||.::...|..|||.|...|....:..
  Fly   409 VLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHT 473

  Fly   326 DHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSF 390
            .....||...:||.|||:|..||.|::||||..:...|:....|    |.:|||:|||....|||
  Fly   474 PLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR----ISILDIFGFEDLAENSF 534

  Fly   391 EQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEAC 455
            ||.||||.||.||..|.:.|.|.||.||.||.:|||.:.:.:|..:..|:.:...||..::|:
  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDD-- 597

  Fly   456 LSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHR-----EDFRITHYAGDVIYNINGFI 515
                   :.....|.|.:..:..||....     .||..|     ::|.:|||||.|.|.::||:
  Fly   598 -------ESNFPRATDLSFLEKCHYNHAL-----SELYARPRIGAQEFGVTHYAGQVWYCVDGFL 650

  Fly   516 EKNKDTLYQDFKRLLHNSKDANLSEM-------------WPEGAQDIKKTTK-RPLTAGTLFQRS 566
            :||:|.|..|...||.:|:...:.|:             .|:|:.....|.| |..|....|..|
  Fly   651 DKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADS 715

  Fly   567 MADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFL 631
            :..|:.::.:..|::|||||||..|.:...|...|..|:||||:|:.:::|:.|:..|.|:..|:
  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780

  Fly   632 LRYKMISQYTWPNFRAGSDRDGVRVLIEEKK----FAQDVKYGHTKIFIRSPRTLFALEHQRNEM 692
            .||:.:  ...|..|....|:..|.|:|...    ...|.:.|.|::|:|..... |||..|.|.
  Fly   781 ERYRHL--LPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR-ALESGRTER 842

  Fly   693 IPHIVTLLQKRVRGWIVRRNFKK------------------------MKAAITIVRAYKAYKLRS 733
            :......:|:.|||.:|||...:                        .|.|:|..|.::..:.|.
  Fly   843 LRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARR 907

  Fly   734 YVQEL-------------ANRLRKAKQMRD--------------------YGKSIQW-------- 757
            .||:|             |.|.|:|::.:.                    |.|...|
  Fly   908 RVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRH 972

  Fly   758 --------PQPPLAGRKVEAKLHRMFDFWRANMI----LHKYPRSE 791
                    |.||.:..::...|.: |.|.:.:.:    |...||.|
  Fly   973 LVKVLGTVPGPPSSAVQLPEDLGQ-FSFGKFSSVYCNGLRLQPRRE 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	263/711 (37%)
		MYSc_Myo1	21..677	CDD:276829	253/684 (37%)
		Myosin_TH1	801..983	CDD:283635
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	261/706 (37%)
		MYSc_Myo15	169..828	CDD:276838	253/684 (37%)
		MyTH4	1014..1171	CDD:295320	3/4 (75%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940