DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo6

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_008764645.1	Gene:	Myo6 / 315840	RGDID:	1560646	Length:	1294	Species:	Rattus norvegicus

Alignment Length:	797	Identity:	262/797 - (32%)
Similarity:	420/797 - (52%)	Gaps:	86/797 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQM-NIYGPETIRKYKGRELFEN 72
            |:|...|..::....:.|::.|:....||||:..:.:::|||..: .||..:||:.|:|:.|...
  Rat    59 VEDNCSLMYLNEATLLHNVKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSDTIKSYQGKSLGTM 123

  Fly    73 APHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLI 137
            .||:|||||.|:|.:|..:....|::||||||||||.:|.:::|:.. :...||:..:|:    :
  Rat   124 PPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTE-SYGTGQDIDDRI----V 183

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202
            ::|.:||.||||||.||:|||||||:::|.|:.|:..|||.:::|||||||:..|...|||:|.|
  Rat   184 EANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIF 248

  Fly   203 YQLLRGANDNELRQ-------------------YELQKETGKY--------HYLNQGSM--DILT 238
            |:|..||:: ::|:                   |...|||.|.        .|:..||:  .:|.
  Rat   249 YRLCAGASE-DIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYVKAGSLKDPLLD 312

  Fly   239 EKSDYKGTCNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQ---TIEDELVISNKQ--HLKSTAK 298
            :..|:...|.|.|.:|...:|...::|.:|.||||||::|:   :......:.||.  .|:..|:
  Rat   313 DHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAPSLEYCAE 377

  Fly   299 LLQVTETELSTALTKRVI---AAG--GNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRA 358
            ||.:.:.:|..:||.||:   |.|  |.|::......||...:|||||.:|..||..::.|:|:.
  Rat   378 LLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANSARDALAKTVYSHLFDHVVDRVNQC 442

  Fly   359 ILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGI 423
            ..|   :|.:.|   ||||||.|||.|:.|||||||||||||||||.|.|.:||:|||.||:||:
  Rat   443 FPF---ETSSYF---IGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGL 501

  Fly   424 EWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLS-----KHPHYTSR 483
            ....:.|.:|:...||:|....||:.|:||         ::.|....|::.:     ||..:...
  Rat   502 GVNEVHYVDNQDCIDLIEVKLVGILDILDE---------ENRLPQPSDQHFTSVVHQKHKDHFRL 557

  Fly   484 QLKPTDKELKHR-----EDFRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWP 543
            .:....|...||     |.|.|.|:||.|.|....|:|||.|.|:...:.|:..|:|..:..::.
  Rat   558 TIPRKSKLAVHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRALFE 622

  Fly   544 EGAQDIKKTTKRP-----LTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEH 603
            ....:.|.|.::.     ::.|..|:..:..|:..|......::||||||...:|..|:..::..
  Rat   623 SSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILS 687

  Fly   604 QVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQ-DV 667
            |::..|::..|.:.:.||..|..:.:.   |.|..:|..........|...:.|.:.....: |.
  Rat   688 QLQCSGMVSVLDLMQGGFPSRASFHEL---YNMYKKYMPEKLARLDPRLFCKALFKALGLNEVDY 749

  Fly   668 KYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMK-AAITIVRAYKAYKL 731
            |:|.||:|.|..:  ||...|..:..|..:..|.|||..|:|...:||:: .::::::.....|.
  Rat   750 KFGLTKVFFRPGK--FAEFDQIMKSDPDHLAELVKRVNLWLVCSRWKKVQWCSLSVIKLKNKIKY 812

  Fly   732 RSYVQELANRLRKAKQM 748
            |:   |...:::|..:|
  Rat   813 RA---EACIKMQKTIRM 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	248/736 (34%)
		MYSc_Myo1	21..677	CDD:276829	241/711 (34%)
		Myosin_TH1	801..983	CDD:283635
Myo6	XP_008764645.1	MYSc	52..771	CDD:214580	248/737 (34%)
		MYSc_Myo6	71..759	CDD:276833	241/711 (34%)
		Myosin-VI_CBD	1177..1267	CDD:293129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010