DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myh7b

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001101264.2	Gene:	Myh7b / 311570	RGDID:	1307994	Length:	1941	Species:	Rattus norvegicus

Alignment Length:	1058	Identity:	321/1058 - (30%)
Similarity:	528/1058 - (49%)	Gaps:	142/1058 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..::..::....:.|||:|:....||||.|..||::|||:.:.:|....:..|||:...|..
  Rat    86 LEDMAMMTHLNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTATVVAAYKGKRRSEAP 150

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIER------- 131
            ||::|:||:||..:.:.:::..:||:||||||||..:|.:::|.|.|. |.|....::
  Rat   151 PHIYAVADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVA-ALGDGPGKKAQFLATK 214

  Fly   132 ----VKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGI----ITNYLLEKSR 188
                :::.:|::|..:|.||||||.||||||||||::.|.|    .|.|.:    |.:|||||||
  Rat   215 TGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHF----GPTGKLASADIDSYLLEKSR 275

  Fly   189 VVQQQPGERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQG--SMDILTEKSDYKGTCNAFK 251
            |:.|.||||.:|.:||:|.|..........|......||:.:||  ::|.:.:..:...|.:|..
  Rat   276 VIFQLPGERGYHVYYQILSGKKPELQDMLLLSMNPYDYHFCSQGVTTVDNMNDGEELIATDHAMD 340

  Fly   252 TLGFSTDEVQTIWRTIAAVLHLGNVEF--QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKR 314
            .||||.||....::.:.|:||.||::|  :..|::......:.....|.|:.|:..:|...|...
  Rat   341 ILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHP 405

  Fly   315 VIAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDI 379
            .:..|...:.|..:..|..:...|||||.|||||.|::||||:.:   .:|...:|  .||||||
  Rat   406 RVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTL---DTKLPRQF--FIGVLDI 465

  Fly   380 YGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQP 443
            .|||||:.|||||.|||:.||||||.|.:.:...|||||:||||:|..|::..:...| ||:|:|
  Rat   466 AGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKP 530

  Fly   444 HKGIIAIMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDV 507
             .||::|::|.|: ..|.:|.:....: |.:..|.|::  :|.:| ||:.|::..|.:.||||.|
  Rat   531 -LGILSILEEECM-FPKASDASFRAKLYDNHSGKSPNF--QQPRP-DKKRKYQAHFEVVHYAGVV 590

  Fly   508 IYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMW------------PEGAQDIKKTTKRPLTAG 560
            .|:|.|::|||||.|.:....:...|::..|:.::            ..|.::.:|......|..
  Rat   591 PYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENYAGSCSTEPPKSGVKEKRKKAASFQTVS 655

  Fly   561 TLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQ 625
            .|.:.::..|:..|...:|.:||||.||:.|:..|.|...|.||:|..|:||.:|:.|.||.:|.
  Rat   656 QLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDSFLVLHQLRCNGVLEGIRICRQGFPNRL 720

  Fly   626 RYDKFLLRYKMISQYTWPNFRAGSDRDGVRVL-----IEEKKFAQDVKYGHTKIFIRSPRTLFAL 685
            .|..|..||::::....|:......|.....|     |:..::    ::||||:|.:: ..|..|
  Rat   721 LYADFRQRYRILNPSAIPDDTFVDSRKATEKLLGSLDIDHTQY----QFGHTKVFFKA-GLLGIL 780

  Fly   686 EHQRNEMIPHIVTLLQKRVRGWIVRRNFKKM----KAAITI---VRAYKAYKLRSYVQELANRLR 743
            |..|::.:..::||||.|.||.::|..:::|    .|..||   :||:.|.|..|:
  Rat   781 EELRDQRLAKVLTLLQARSRGRLMRLEYQRMLGGRDALFTIQWNIRAFNAVKNWSW--------- 836

  Fly   744 KAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGR 808
                |:.:.|.    :|.|...:.|.:|..:              |:|...||..:  |||.|.|
  Rat   837 ----MKLFFKM----KPLLRSAQAEEELAAL--------------RAELRGLRGAL--ATAEAKR 877

  Fly   809 RPYWGQARRWVGDYLANSQENSGYEAYNGS--IKNIRNHPADGETFQQVLFSSFVK---KFNHFN 868
            :.            |..:|.:...|..:.:  ::..:::.||.|....:|..|.|:   |....|
  Rat   878 QE------------LEETQVSVTQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEAKVKELN 930

  Fly   869 KQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLES 933
            ::......|:.....:...::::..::|:.|...|||.......:      .:::||  |.:|..
  Rat   931 ERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEK------QATENK--VKNLTE 987

  Fly   934 EYTPLKEDRIGEVVGIVCKK----------YHDLTGTELRVNVTTNISCRLDGKARII--TVEAA 986
            |...|.|    .||.:..:|          ..||...|.||:.......||:.:...:  ::|..
  Rat   988 EMAALDE----SVVRLTKEKKALQEAHQQALGDLQAEEDRVSALAKAKIRLEQQVEDLECSLEQE 1048

  Fly   987 SNVEVPNFRPK---EGNI 1001
            ..:.:...|.|   ||::
  Rat  1049 KKLRMDTERAKRKLEGDL 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	249/718 (35%)
		MYSc_Myo1	21..677	CDD:276829	245/693 (35%)
		Myosin_TH1	801..983	CDD:283635	39/198 (20%)
Myh7b	NP_001101264.2	Myosin_N	32..71	CDD:397036
		myosin head (motor domain)	86..773		246/705 (35%)
		MYSc_Myh7b	98..773	CDD:276953	245/693 (35%)
		Myosin_tail_1	853..1930	CDD:396244	50/254 (20%)
		myosin tail	1075..1933
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000