DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myh15

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_038944797.1	Gene:	Myh15 / 303965	RGDID:	1565858	Length:	1987	Species:	Rattus norvegicus

Alignment Length:	1084	Identity:	317/1084 - (29%)
Similarity:	520/1084 - (47%)	Gaps:	172/1084 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..:|..::....:..||||:.:..||||.|..||::|||:.:.:|..|.:..||.:...|..
  Rat    85 IEDLSMLLYINEGSVLHTLRKRYDHWMIYTYSGLFCVAINPYKWLPVYQKEVMAAYKRKRRSEAP 149

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAV-TNAQGQNEIERVKNVLI 137
            ||:||:|:.|::.:.:..::..||.:||||:|||..:|:|::|.|.: ..::.:.::..:::.::
  Rat   150 PHIFAVANHAFQDMLRNGENQSILFTGESGSGKTVNTKMIIQYFATMAATSEPKKKLGNLEDQIV 214

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202
            |.|.|||.||||||.||||||||||::.:.|..:.......|..|.|||||||.|||||||:|.|
  Rat   215 QMNPILEAFGNAKTLRNDNSSRFGKFIRMYFGVRGTLSFADIQIYFLEKSRVVYQQPGERNYHIF 279

  Fly   203 YQLLRGANDNELRQYEL-QKETGKYHYLNQG--SMDILTEKSDYKGTCNAFKTLGFSTDEVQTIW 264
            ||:|.|  ..||:...| ......:|..:.|  :::.|.:...:..|..|...|||..||....:
  Rat   280 YQILSG--KQELQDMLLVSTNPSDFHICSCGVVAVENLDDAKGFLATEKAIDVLGFLPDEKFGCY 342

  Fly   265 RTIAAVLHLGNVEFQ--TIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQKDH 327
            :.:.|::|.||::|:  ..|::|.....::....|.|:.:..:||...|....|..|...:.:..
  Rat   343 KLVGAIMHFGNLKFRQNPREEQLEADGTENADKAALLMGINASELLKGLIYPRIKVGNEYVTRSQ 407

  Fly   328 NATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQ 392
            |..|..|...||:|:||:|:|.|:::|:|:.:   .:|..:.|  .||:|||.||||.|.||.||
  Rat   408 NIQQVTYAVGALSKSIYERMFKWLVARMNQVL---DAKVTSHF--FIGILDITGFEILDYNSLEQ 467

  Fly   393 FCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHKGIIAIMDEACL 456
            .|||:.||||||.|.:.:...||||.::||::|.:|:|..:...| ||:|:| .||::|::|.|:
  Rat   468 LCINFTNEKLQQFFNQQLFVLEQEECRKEGLDWMSIDYGLDLQACIDLIEKP-MGILSILEEECM 531

  Fly   457 SVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKDT 521
             :.|.||:|.   ..|..:.|...::...|||..|......|.:.||||.|.|:|:|:|.|||:.
  Rat   532 -LPKATDNTF---KTKLFAHHFGKSAYFQKPTAPEKNFEVHFELAHYAGVVPYDISGWIGKNKEL 592

  Fly   522 LYQDFKRLLHNSKDANLSEMWP------EGAQDIKKTTKRPLTAGTLFQ-------RSMADLVVT 573
            |.:....||..|.:..|:.::.      .|..|..:..::|....|.||       .|:..|:..
  Rat   593 LNETVVALLQKSSNKVLASLFTNNTIAGSGELDSIEFGEKPRRKATSFQLITSLHKESINKLMAD 657

  Fly   574 LLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRY---- 634
            |....|.:||||.||:.|...|.|...|..|:|..|:||..||....|..|..||.|..||
  Rat   658 LKSTAPHFVRCINPNENKIPGVMDPFWVLQQLRCNGVLEGTRVCCKAFPIRMLYDDFKQRYCILN 722

  Fly   635 -KMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVT 698
             ::.|:..:.|.|..::.....:.|::.::    :.|.||:|.:: |.|..||.:|:|.|..:.|
  Rat   723 PRIFSKSKFVNIRKATEEVLALLEIDQSQY----QCGVTKVFFKA-RILDRLEERRDEKISKVFT 782

  Fly   699 LLQKRVRGWIVRRNFKKM---KAAITI----VRAYKAYKLRSYV----------------QELAN 740
            |.|.|.||.::|..|:|:   :.|:.:    :||:.|.|...::                :|:|.
  Rat   783 LFQARARGKLMRITFQKILEERDALALIQENIRAFIAVKTWPWMGLFFKVKPLAKSVGAGEEIAG 847

  Fly   741 RLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATAL 805
            ...:..|::   ||::..:    .::.|.|..::......|.:|          |:||....|
  Rat   848 LKEECAQLQ---KSLETSE----SQREELKTKQVSLVQERNDLL----------LQLQAEQET-- 893

  Fly   806 AGRRPYWGQARRWVGDYLANSQE------NSGYEAYNGSIKNIRNHPADGETFQQVLFS------ 858
                             ||||:|      .|..| ....||.:.....:.|.....|.:
  Rat   894 -----------------LANSEELCESLIKSKIE-LEAKIKELSRRVEEEEEINSELTARGRKLE 940

  Fly   859 ---SFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTI--KIRELTSISVSPGRDQLIV 918
               |.:||                 .|:.|:.|..|.:..|...  |:|.||        :::..
  Rat   941 DECSELKK-----------------EIYDLEAILAKSEKAKCAAEHKVRNLT--------EEVHS 980

  Fly   919 FHSSKNKDLVFSLES---------EYTPLKEDRIGEVVGIVCKKYHDLTGTE--LRVNVTTNISC 972
            .|...:| |..::::         |:..::|:::..|..:..|....:...|  |.......:.|
  Rat   981 LHEDVSK-LTRAMQAAQEAQQQTQEHLHIEEEKLSNVSKVNQKLSQQVDALEGDLERERKARMKC 1044

  Fly   973 -----RLDGKARIITVEAASNVE------VPNFRPKEGNIIFEV 1005
                 :|:|:.: :..|.|.|:|      :...|.||    ||:
  Rat  1045 EREKHKLEGELK-LNQEGAENLESSRQQLIEQLRKKE----FEM 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	243/705 (34%)
		MYSc_Myo1	21..677	CDD:276829	237/680 (35%)
		Myosin_TH1	801..983	CDD:283635	36/214 (17%)
Myh15	XP_038944797.1	Myosin_N	31..70	CDD:397036
		Motor_domain	98..762	CDD:419868	237/679 (35%)
		Myosin_tail_1	843..1919	CDD:396244	57/309 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000