DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo1a

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_062197.1	Gene:	Myo1a / 299509	RGDID:	3135	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1079	Identity:	418/1079 - (38%)
Similarity:	599/1079 - (55%)	Gaps:	142/1079 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MQREAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGR 67
            ::...||:|.:||:.:..|..:.||:.|::...||||||.|.:|||||:|:.|||||.|.||:..
  Rat     4 LEGSVGVEDLILLEPLDEESLIKNLQLRYEKKEIYTYIGNVVISMNPYQQLPIYGPEFIAKYRDY 68

  Fly    68 ELFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERV 132
            ..:|..||::|:|:.||:.||.|.:|.||||:||||||||||||::|.|:|||. .:|: ::..|
  Rat    69 TFYELKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVC-GKGE-QVNSV 131

  Fly   133 KNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGER 197
            |..|:|||.:||.||||||.|||||||||||||||||:|..|:||:||||||||||||:|..|||
  Rat   132 KEQLLQSNPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGER 196

  Fly   198 NFHSFYQLLRGANDNELRQYELQKETGKYHYLN-----QGSMDILTEKSDYKGTCNAFKTLGFST 257
            |||.|||||.||:...|:..:|:::...|.|||     ...||   :.|:::...||...:|||.
  Rat   197 NFHIFYQLLAGADTQLLKALKLEEDARGYAYLNGEVSRVNGMD---DASNFRAVQNAMAVIGFSE 258

  Fly   258 DEVQTIWRTIAAVLHLGNVEFQTIEDELV--------ISNKQHLKSTAKLLQVTETELSTALTKR 314
            :|::.:....|.||.||||:   :.||..        :.:.:.::...:::.:...||..||..|
  Rat   259 EEIRQVLEVTALVLKLGNVK---LADEFQANGLPASGVCDGKGIQEIGEMMGLNSAELEKALCSR 320

  Fly   315 VIAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAI-LFRGSKTQARFNSVIGVLD 378
            .:..|...:....|..||:|.:|||||.||.|||.||::|||.:| :..|.|     ..|:||||
  Rat   321 TMETGKEKVVTVLNVIQAQYARDALAKNIYSRLFDWIVNRINESIKVGTGEK-----RKVMGVLD 380

  Fly   379 IYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQP 443
            ||||||.:.||||||.||||||||||:||||.||:|||||:||||.||.:|||:|.|||||:|..
  Rat   381 IYGFEILEDNSFEQFVINYCNEKLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICDLIEHS 445

  Fly   444 HKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHR---EDFRITHYAG 505
            .:||:|::||.||..|.|:|.|.|..:::..|||.||.|:..:...::....   ..|||.||||
  Rat   446 QRGILAMLDEECLRPGVVSDTTFLAKLNQLFSKHSHYESKVTQNAQRQYDRTMGLSCFRICHYAG 510

  Fly   506 DVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADL 570
            .|.||:..||:||.|.|::|..:.:..::...|..::||| ...:.:.|||.||||.|:.|:|.|
  Rat   511 KVTYNVTSFIDKNNDLLFRDLSQTMWKAQHPLLHSLFPEG-NPKEASLKRPPTAGTQFKNSVAIL 574

  Fly   571 VVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYK 635
            :..|..|.|.|:|||||||.:....|..|.|..|.||||||||:||||||:..||.|..||.||:
  Rat   575 MKNLYSKNPNYIRCIKPNDQQQQGRFTSELVMVQARYLGLLENVRVRRAGYAFRQAYKPFLERYR 639

  Fly   636 MISQYTWPNFRAGSDRDGV-RVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTL 699
            ::|:.|||.:. |.||:|| :||......::::.||.||||||||:|||.||.||...:..:.||
  Rat   640 LLSRSTWPRWN-GEDREGVEKVLGSLILSSEELAYGRTKIFIRSPKTLFYLEEQRRLRLQQLATL 703

  Fly   700 LQKRVRGWIVRRNFKKMKAAITIVRAY-------KAY-KLRSYVQELANRLRKAKQMRDYGKSIQ 756
            :||..|||..|.::::|:.:..::.|:       |.| |:||.|..:...:|..|..::|.|..:
  Rat   704 IQKVYRGWRCRTHYQQMRKSQILISAWFRGNKQKKHYGKIRSSVLLIQAFVRGWKARKNYRKYFR 768

  Fly   757 ------------------------------------WPQPPL-AGRKVEAKLHRMFDFWRANMIL 784
                                                ||..|. .......:|..:|..|:.....
  Rat   769 SGAAITLANFIYQSITQKFLLNLKKNLPSTKVLDNTWPAAPYRCFNTANQELQHLFYQWKCKKYR 833

  Fly   785 HKYPRSEWPQLRLQIIAATALAGRRPYWGQA--RRWVGDYLANSQENSGYEAYNGSIKNIRNHPA 847
            .:....:...||.::.|:....|::..:.|:  ..:.|||:       |.:. |..::.::
  Rat   834 DQLSPKQVQTLREKLCASELFKGKKASYLQSVPVPFRGDYV-------GLQG-NPKLQRLK---- 886

  Fly   848 DGETFQQVLFSSFVKKFNHFN-KQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSP 911
             |.....||.:..|||.|..| |.::|..:::...:...|..|::   .:..||:.::..:||:.
  Rat   887 -GREEGPVLVADTVKKVNRGNGKTSSRILLLTKGHVILTDAKKSQ---AQIVIKLEDVAGVSVTS 947

  Fly   912 GRDQLIVFH-------SSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKKYH---DLTGTELRVNV 966
            ..|.|...|       :||...|:.|             ..:|.::.|.|.   |.|..:|.|.|
  Rat   948 LEDGLFSLHLSEMSSAASKGDILLIS-------------DHLVELLTKMYQAVLDATQRQLPVTV 999

  Fly   967 TTNISCRLDGKARIITVEAASNVEVPNFRPKEGNIIFEV 1005
            |...|.|.                      |||::..:|
  Rat  1000 TEKFSVRF----------------------KEGSVAVKV 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	343/701 (49%)
		MYSc_Myo1	21..677	CDD:276829	328/673 (49%)
		Myosin_TH1	801..983	CDD:283635	42/194 (22%)
Myo1a	NP_062197.1	MYSc_Myo1	22..681	CDD:276829	328/673 (49%)
		IQ	742..764	CDD:197470	6/21 (29%)
		Myosin_TH1	847..1042	CDD:399188	46/221 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53790
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730