Protein Alignment Myo31DF and MYO1H

DIOPT Version :9

• Sequence 1: NP_001188784.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Alignment Length: 1079
• Identity: 406/1079 - (37%)
• Similarity: 584/1079 - (54%)
• Gaps: 148/1079 - (13%)

  Fly     6 EAGVQDFVLLDQVSMEK-FMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            :.|||||||||..:.|. |:|||||||....||||||.:.||:|||:::.||....:..|:|...
Human    10 KVGVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVNF 74

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            ||..||::||||:|||::.....:..||||||||||||||||.|::|. |||....|: ::..::
Human    75 FELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILEYF-AVTCPMTQS-LQIARD 137

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
            .|:.||.:||.||||:|.||||||||||||||:||::..||||.|.:||:||||||.|..|||||
Human   138 RLLFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNF 202

  Fly   200 HSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQ 261
            |.|||||.|..:..|....|:::...|.||:||   ....:::|:|:|...|||..:.|:..:::
Human   203 HIFYQLLAGGEEERLSYLGLERDPQLYKYLSQGHCAKESSISDKNDWKTVSNAFSVIDFTEADLE 267

  Fly   262 TIWRTIAAVLHLGNVEFQTIEDE---LVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVM 323
            .::..||:||||||:.|:  ||:   ..|.:...:|..||||.|..:.|..|||.|.|.|....:
Human   268 NLFGIIASVLHLGNIGFE--EDDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEAKTEEV 330

  Fly   324 QKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSN 388
            ........:.|.:||:|||:|.|.|||::::||.:::   :|...| .:|||:|||||||:||.|
Human   331 ICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLV---NKDFTR-KTVIGLLDIYGFEVFDKN 391

  Fly   389 SFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDE 453
            .||||||||||||||||.||..||.||.||:.|||||..|:||||||||||||:.|||||:|:||
Human   392 GFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIICDLVEERHKGIISILDE 456

  Fly   454 ACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLK-PTDKELKHREDFRITHYAGDVIYNINGFIEK 517
            .|:..|..||.:.|..:::.:.||.|:.:|:|. |..::.....:||:.||||:|.|...||:||
Human   457 ECIRPGPATDLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGFLEK 521

  Fly   518 NKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYV 582
            |.|.||:..|.:|..||:..|.|.:.....:   ..:||.|.||.|:.|::.|:.||:.|||.|:
Human   522 NNDLLYRHLKEVLCKSKNIILRECFLLAELE---NRRRPPTVGTQFKNSLSSLLETLISKEPSYI 583

  Fly   583 RCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLL--------------- 632
            |||||||.|..:.||:..:.||::||||:|:||||||||.:|::|:.||.
Human   584 RCIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYLGVELSHWVERLM 648

  Fly   633 -------RYKMISQYTWPNFRAGSDRDGVRVLIEEKKF-AQDVKYGHTKIFIRSPRTLFALE--- 686
                   |||.:...|||::. |...:||..||:...: .::.|.|.||||||.||||||.|
Human   649 MSLFYKDRYKSLCPDTWPHWH-GPPAEGVERLIKYIGYKPEEYKLGKTKIFIRFPRTLFATEDAF 712

  Fly   687 ----HQ--------------RNEMIP--HIVTLLQKRVRGWIVRRNFKKMKAAITIVRAY-KAYK 730
                ||              |.|.:.  .....|:...||.:.|:..::.|.|:.|:|.: |.:.
Human   713 EFSKHQLVARIQATYKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRKWAVRIIRKFIKGFI 777

  Fly   731 LR-----------------SYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFW 778
            .|                 :|:..|  |....|.:.|  ||  |.:||.........|.:|.
Human   778 SRNKPLCPDNEEFIVFVRKNYILNL--RYHLPKTVLD--KS--WLRPPGILENASDLLRKMC--- 833

  Fly   779 RANMILHKYPR----SEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSI 839
             ...::.||.|    .....::.:::.:....||:..:.::   :.....||:.:.|  ..|..:
Human   834 -VRNLVQKYCRGITAERKAMMQQKVVTSEIFRGRKDGYTES---LNQPFVNSRIDEG--DINPKV 892

  Fly   840 KNIRNHPADGETFQQVLFSSFVKKFNHFN-KQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRE 903
            ..:.:|       :::.:...|.|::... |...|..|::....:.::..|     :|:.|:...
Human   893 LQLISH-------EKIQYGVPVIKYDRKGFKARQRQLILTQKAAYVVELAK-----IKQKIEYSA 945

  Fly   904 LTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRI---GEVVGIVCKKYHDLTGTELRVN 965
            |..:|.|...|.::|.|.|          .|.:..|.|.:   |.|...|.|... |...|..||
Human   946 LKGVSTSNLSDGILVIHVS----------PEDSKQKGDAVLQCGHVFEAVTKLVM-LVKKENIVN 999

  Fly   966 VTTNISCRLDGKARIITVEAASNVEVPNFRPKEGNIIFE 1004
            |       :.|..:......           |||.|:|:
Human  1000 V-------VQGSLQFFISPG-----------KEGTIVFD 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	339/735 (46%)
		MYSc_Myo1	21..677	CDD:276829	319/686 (47%)
		Myosin_TH1	801..983	CDD:283635	35/185 (19%)
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	337/712 (47%)
		MYSc_Myo1	26..700	CDD:276829	318/685 (46%)
		Myosin_TH1	856..1019	CDD:283635	39/208 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720