DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo95E

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster

Alignment Length:	1342	Identity:	331/1342 - (24%)
Similarity:	547/1342 - (40%)	Gaps:	413/1342 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MQREAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGR 67
            |::|.|..|.|||:.:|.:.|::|:.:|::...||||||...|::|||..::.:..:.:|.|..:
  Fly     1 MEQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDK 65

  Fly    68 ELFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYI--------------- 117
            .:|:..||::.:.:.||:.||.:.:|.|:|::|||||||||..|:|:.::
  Fly    66 GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNV 130

  Fly   118 ----------------------------------------------------------------- 117

  Fly   131 LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAES 195

  Fly   118 ----------------------------------------------------------------- 117

  Fly   196 IERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGS 260

  Fly   118 ---------------------------------------------AAVTN--------------- 122
                                                         .|.||
  Fly   261 PKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQ 325

  Fly   123 --AQGQNEIERVKNVLIQS---------------------------------------------- 139
              .:.|.|.||.::.|:.|
  Fly   326 HSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQ 390

  Fly   140 ---------NAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPG 195
                     :..||..|||.|.:|:||||:||..|||.|:|.||:|..||:|:|||:|:.....|
  Fly   391 RMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIG 455

  Fly   196 ERNFHSFYQLLRGANDNELRQYELQKETGKYHYL-NQGSMDILTEKSDYKGTCNAFKTLGFSTDE 259
            |||||.|||||.||:...|:..:|.:...||..| |..:|:  .::.::..|..:...||.|.:|
  Fly   456 ERNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAME--EDRMNFHYTKRSLDVLGLSCEE 518

  Fly   260 VQTIWRTIAAVLHLGNVEFQTI-----EDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAG 319
            ..:|:|.||.||.|||..|..|     .:...:||...::.||:||.:....|...||:   |..
  Fly   519 SNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTR---ANS 580

  Fly   320 GNVMQKD----HNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIY 380
            .|..|:|    .:|.||...::.|.:.:|.|||||::::||.::    ..||...|  :.:||.|
  Fly   581 TNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL----KSTQREKN--LALLDFY 639

  Fly   381 GFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHK 445
            |||..|.||||||.|||..||:.|.|:..||:.|||.|.|||:||:.|:||:|:.||:|:::|..
  Fly   640 GFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSY 704

  Fly   446 GIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYN 510
            ||:::::|..|:    ::|.||..:.:..:.||::.:..        .:...|:|.|||..|.|:
  Fly   705 GILSLINEPHLN----SNDALLLRVQQCCAGHPNFMTTG--------SNSMCFQIRHYASVVNYS 757

  Fly   511 INGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLL 575
            |:.|:|||.|.|.:......:.||.:.:..::||| ...::.||:|.|..:..:..:..|:..:.
  Fly   758 IHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEG-NPRRQVTKKPSTLSSNIRTQLQTLLAIVK 821

  Fly   576 KKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQY 640
            .:...||.|||||:.|....||...|:|||||:.|:..:.:.|.|..:...:.||..|||:::..
  Fly   822 HRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSL 886

  Fly   641 TWPNFRAGSDRDGVRVLIEEKKF-AQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRV 704
            |||:|..||..:|:.::|..... :.:...|...:|:|||||::.||..|...|..:..|:|...
  Fly   887 TWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMF 951

  Fly   705 RGWIVRRNFKKMKA-------------------------------------------------AI 720
            |.:..|:.|::|:.                                                 ||
  Fly   952 RMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAI 1016

  Fly   721 TIV-RAYKAYKLRSYVQELANRL--RKAKQMRDYGKSIQWPQPPL----AGRKVEAKLHRMFDFW 778
            .|: |.|:.:|:|.::..:..||  .....:     |.:||..|.    |.|.:.:..||    |
  Fly  1017 DIIGRYYRQWKIRQFLLTIPLRLPPNTLSPL-----STEWPVAPAFLADASRHLRSIYHR----W 1072

  Fly   779 RANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQA--RRWVGDYLANSQENSGYEAYNGSIKN 841
            :..:..:.:.::...::|.::.|:.....|:..:|::  ..:||||:.        ..:|...|.
  Fly  1073 KCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVR--------LRHNQQWKK 1129

  Fly   842 IRNHPADGETFQQVLFSSFVKKF-NHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIR--- 902
            |.....|    |.|:|:..:.|. ....|......::|.|::..||         :||::|:
  Fly  1130 ICAETND----QYVVFADIINKIARSSGKFVPILLVLSTSSLLLLD---------QRTLQIKYRV 1181

  Fly   903 ---ELTSISVSPGRDQLIVFH------SSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKKY---H 955
               |:..:|:||..|.:.|||      ..|..|.||            :.|.|:.||.|.:   .
  Fly  1182 PASEIYRMSLSPYLDDIAVFHVKASEFGRKKGDFVF------------QTGHVIEIVTKMFLVIQ 1234

  Fly   956 DLTGTELRVNVTTNISCRLDGKARIITVEAASNVEVPNFRPK 997
            :.||....::::|........:..|.:.:.....::....||
  Fly  1235 NATGKPPEIHISTEFEANFGQQTVIFSFKYGGMSDLAQGPPK 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	257/956 (27%)
		MYSc_Myo1	21..677	CDD:276829	243/928 (26%)
		Myosin_TH1	801..983	CDD:283635	44/199 (22%)
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	36/98 (37%)
		Motor_domain	403..924	CDD:277568	198/544 (36%)
		Myosin_TH1	1092..1267	CDD:283635	44/207 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466278
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750